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| 1 | Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal,healthy stomach显示文摘AIM:To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa:i.e.those with Helicobacter pylori(H pylori)gastritis or atrophic gastritis,who have a high risk of gastric cancer or peptic ulcer diseases.METHODS:Among 162 Japanese outpatients,pepsinogen-(Pg-)and(Pg)were measured using a conventional Japanese technique,and the European GastroPanel examination(Pg and Pg,gastrin-17 and H pylori antibodies).Gastroscopy with gastric biopsies was performed to classify the patients into those with healthy stomach mucosa,H pylori non-atrophic gastritis or atrophic gastritis.RESULTS:Pg-and Pg assays with the GastroPanel and the Japanese method showed a highly significant correlation.For methodological reasons,however,serum Pg-,but not Pg,was twice as high with the GastroPanel test as with the Japanese test.The biomarker assays revealed that 5%of subjects had advanced atrophic corpus gastritis which was also verified by endoscopic biopsies.GastroPanel examination revealed an additional seven patients who had either advanced atrophic gastritis limited to the antrum or antrum-predominant H pylori gastritis.When compared to the endoscopic biopsy findings,the GastroPanel examination classified the patients into groups with 'healthy' or 'diseased' stomach mucosa with 94% accuracy,95% sensitivity and 93% specifi city.CONCLUSION:Serum biomarker tests can be used to differentiate between subjects with healthy and diseased gastric mucosa with high accuracy. | Katsunori Iijima Yasuhiko Abe Ryosuke Kikuchi Tomoyuki Koike Shuichi Ohara Pentti Sipponen Tooru Shimosegawa | 2009 | World Journal of Gastroenterology2009，15，7： | 25 |
| 2 | 叙事性游戏中成人的游戏引导与儿童的游戏发展显示文摘依据维果斯基的游戏理论和最近发展区理论,成人对幼儿游戏的指导具有重要作用。在幼儿游戏中,若成人无法把握幼儿的最近发展区,就意味着游戏参与失败。只有采用恰当的方法促进幼儿游戏最近发展区的发展,成人才能成为幼儿游戏的'优秀'支持者。本研究采用叙事研究方法,在7年实验研究的基础上,发现成人干预幼儿游戏发展的有效途径和策略具有如下显著特征:能激发共有主题;能在游戏中积极扮演恰当的角色;能全身心投入,有情感参与;与幼儿之间有角色的对话与互动;创编的游戏剧情张弛有力;剧本衔接有序,情节精彩;能精心设计角色扮演干预时机。学前教师教育课程应避免理论与实践脱节的弊端,加强对幼儿教师指导和干预幼儿游戏能力的培养。 | Pentti Hakkarainen Milda Bredikyte Kaisa Jakkula Hikka Munter | 2014 | 学前教育研究2014，，4： | 11 |
| 3 | Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection显示文摘AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing H.pylori infection,eight showed H.pylori antibodies by immunoblotting.All eight had elevated PCA and 4/8 also had IF antibodies.Of the six immunoblot-negative patients with severe corpus atrophy,PCA and IF antibodies were detected in four.Among the patients with low to moderate grade atrophic gastritis(all except one with an ongoing H.pylori infection),serum markers for gastric atrophy and autoimmunity were seldom detected.However,one H.pylori negative patient with mild atrophic gastritis had PCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of H.pylori infection in autoimmune gastritis,and positive autoimmune serum markers in H.pylori gastritis suggest an etiological role for H.pylori in autoimmune gastritis. | Lea Irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi Iris Kaarina Rautelin | 2010 | World Journal of Gastroenterology2010，16，1： | 10 |
| 4 | Low circulating levels of gastrin-17 in patients with Barrett's esophagus显示文摘AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett controls.METHODS: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract.Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents.RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels <0.5, <1, or <1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P<0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P<0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls. | Pentti Sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen | 2005 | World Journal of Gastroenterology2005，11，38： | 6 |
| 5 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 6 | 基于反向方法的船体冰载荷研究(英文)显示文摘船舶碰撞海冰引起的冰载荷分布是十分复杂的。文章选取Thikhonov正则化这一反向方法,根据极地科考补给船S.A Agulhas II号于2013-2014年间南极航行时实测的数据,分析得到了船体艉肩部的冰载荷。通过应用三种独立的冰载荷离散方式来模拟海冰的自然特性,在有限元中得到模型的影响矩阵,并应用Matlab对Thikhonov正则化方程进行了优化。研究结果表明,反向方法可以克服数据处理过程中的不适定性,并计算得到船体冰载荷。 | 刘瀛昊 SUOMINEN Mikko KUJALA Pentti | 2016 | 船舶力学2016，20，12： | 4 |
| 7 | 多层帘式涂布和一种新型压光技术显示文摘帘式涂布是一种低冲击预计量涂布方式,可用于纸和纸板的涂布。帘式涂布技术所产生的涂层为仿形涂层,因而能提供良好的纤维覆盖。在多层帘式涂布中,可以同时进行多层涂布。与单层帘式涂布相比,多层帘式涂布具有许多优点:投资成本更低、设计不同涂层性质更具灵活性、具有更大的涂布操作空间及涂层更薄等。 | Pentti Rautiainen Mika Viljanmaa Henri Vaittinen Jouni Haavisto Robert Urscheler Seppo Luomi Antti Aronen 苏艳群(译) 邝仕均(校) | 2008 | 国际造纸2008，27，5： | 3 |
| 8 | Inflammation as a Risk Factor for Atrial Fibrillation显示文摘 | Ronnier J. Aviles David O. Martin Carolyn Apperson-Hansen Penny L. Houghtaling Pentti Rautaharju Richard A. Kronmal Russell P. Tracy David R. Van Wagoner Bruce M. Psaty Michael S. Lauer Mina K. Chung | 2003 | Circulation: Journal of the American Heart Association2003，，24： | 2 |
| 9 | Seismic design and analysis of nuclear power plant structures显示文摘The seismic design and analysis of nuclear power plant (NPP) begin with the seismic hazard assessment and design ground motion development for the site. The following steps are needed for the seismic hazard assessment and design ground motion development:a. the development of regional seismo-tectonic model with seismic source areas within 500 km radius centered to the site;b. the development of strong motion prediction equations; c. logic three development for taking into account uncertainties and seismic hazard quantification;d. the development of uniform hazard response spectra for ground motion at the site;e. simulation of acceleration time histories compatible with uniform hazard response spectra. The following phase two in seismic design of NPP structures is the analysis of structural response for the design ground motion. This second phase of the process consists of the following steps:a. development of structural models of the plant buildings;b. development of the soil model underneath the plant buildings for soilstructure interaction response analysis;c. determination of instructure response spectra for the plant buildings for the equipment response analysis. In the third phase of the seismic design and analysis the equipment is analyzed on the basis of in-structure response spectra. For this purpose the structural models of the mechanical components and piping in the plant are set up. In large 3D-structural models used today the heaviest equipment of the primary coolant circuit is included in the structural model of the reactor building. In the fourth phase the electrical equipment and automation and control equipment are seismically qualified with the aid of the in-structure spectra developed in the phase two using large three-axial shaking tables. For this purpose the smoothed envelope spectra for calculated in-structure spectra are constructed and acceleration time is fitted to these smoothed envelope spectra. | Pentti Varpasuo | 2013 | Engineering Sciences2013，11，3： | 2 |
| 10 | Dynamic mechanical and mechanical properties of polypropylene/poly( vinyl butyral) /mica composites显示文摘 | Pirkko A Jarvela Li Shucai Pentti K Jarvela | 1997 | Journal of Applied Polymer Science1997，65，10： | 1 |
| 11 | A Tentative Model for the Volume of Trade Between Countries显示文摘 | | 1963 | Weltwirtschafliches Archive1963，，90： | 1 |
| 12 | A four‐year prospective study on intraocular pressure in relation to phacoemulsification cataract surgery显示文摘 | AuraFalck NinaHautala NinaTurunen Pentti JuhaniAiraksinen | 2011 | Acta Ophthalmologica2011，，7： | 1 |
| 13 | New age- and sex-specific criteria for QT prolongation based on rate correction formulas that minimize bias at the upper normal limits显示文摘 | Pentti M. Rautaharju Jay W. Mason Toshio Akiyama | 2014 | International Journal of Cardiology2014，，： | 1 |
| 14 | A Tentative Model for the Volume of Trade Between Countries显示文摘 | Pentti P | 1963 | Weltwirtschaftliches Archiv1963，90，： | 1 |
| 15 | A study of pedestrian traffic in helsinki : methods and results 显示文摘 | Kari Lautso Pentti Murole | 1974 | Traffic Engineering and Control1974，，： | 1 |
| 16 | Neurosteroid hormone vitamin D and its utility in clinical nutrition显示文摘 | Allan V Pentti T | 2007 | Curt Opin Clin Nutr Metab Care2007，10，： | 1 |
| 17 | Access to print materials-role of print repositories the development of the concept显示文摘 | Vattulainen Pentti | 2005 | Library Management2005，26，12： | 1 |
| 18 | Traffic simulation based ship collision probability modelling显示文摘 | Floris Goerlandt Pentti Kujala | 2011 | Reliability Engineering&System Safety2011，96，1： | 1 |
| 19 | 显示文摘 | MARP PENTTI K | 1998 | Anal Chim Acta1998，360，： | 1 |
| 20 | Steel sandwich panels in marine appli- cations显示文摘 | Pentti Kujala Alan Klanac | 2005 | Brodo Gradnja2005，56，4： | 1 |
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