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| 1 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 2 | Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias显示文摘AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.METHODS:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy(FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications.Upper endoscopy using high definition whitelight,2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination.Two patients used as controls had normal endoscopy and histological results.Prospectively,videos were watched blind from histological results by three trained FICE technique endoscopists.RESULTS:The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined.Videos did not identify irregular vascular patterns using high definition white light endoscopy,while acid acetic-FICE combined visualised one in 86% of cases.CONCLUSION:Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus. | Marine Camus Romain Coriat Sarah Leblanc Catherine Brezault Benoit Terris Elise Pommaret Marianne Gaudric Ariane Chryssostalis Frederic Prat Stanislas Chaussade | 2012 | World Journal of Gastroenterology2012，18，16： | 5 |
| 3 | 临床证据(14) 急性肾衰竭显示文摘背景知识 定义 急性肾衰竭(ARF)是指肾小球滤过率突然和持续性下降,导致尿素和其他化学物质在血液中堆积。目前还没有清晰一致的生化学定义,但多数研究的定义为血清肌酐(Scr)2~3mg/dL(200-250 μmol/L),在Scr基础值小于2 mg/dL(170μmol/L)时,升高0.5 mg/dL(45μmol/L) | John Kellum Martine Leblanc Ramesh Venkataraman 陈旻 | 2003 | 英国医学杂志中文版2003，6，3： | 5 |
| 4 | Carbon storage and net primary productivity in Canadian boreal mixedwood stands显示文摘Canadian boreal mixedwood forests are extensive,with large potential for carbon sequestration and storage;thus,knowledge of their carbon stocks at different stand ages is needed to adapt forest management practices to help meet climate-change mitigation goals.Carbon stocks were quantified at three Ontario boreal mixedwood sites.A harvested stand,a juvenile stand replanted with spruce seedlings and a mature stand had total carbon stocks(±SE)of 133±13 at age 2,130±13 at age 25,and 207±15 Mg C ha^-1 at age 81 years.At the clear-cut site,stocks were reduced by about 40%or 90 Mg C ha^-1 at harvest.Vegetation held 27,34 and 62%of stocks,while detritus held 34,29 and 13%of stocks at age 2,25 and 81,respectively.Mineral soil carbon stocks averaged 51 Mg C ha^-1,and held 38,37 and 25%of stocks.Aboveground net primary productivity(±SE)in the harvested and juvenile stand was 2.1±0.2 and 3.7±0.3 Mg C ha^-1 per annum(p.a.),compared to 2.6±2.5 Mg C ha^-1 p.a.in the mature stand.The mature canopies studied had typical boreal mixedwood composition and mean carbon densities of 208 Mg C ha^-1,which is above average for managed Canadian boreal forest ecosystems.A comparison of published results from Canadian boreal forest ecosystems showed that carbon stocks in mixedwood stands are typically higher than coniferous stands at all ages,which was also true for stocks in vegetation and detritus.Also,aboveground net primary productivity was typically found to be higher in mixedwood than in coniferous boreal forest stands over a range of ages.Measurements from this study,together with those published from the other boreal forest stands demonstrate the potential for enhanced carbon sequestration through modified forest management practices to take advantage of Canadian boreal mixedwood stand characteristics. | Nicholas J.Payne D.Allan Cameron Jean-Denis Leblanc Ian K.Morrison | 2019 | Journal of Forestry Research2019，30，5： | 4 |
| 5 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 6 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 7 | Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases显示文摘 | Jeremy Dupaul-Chicoine Garabet Yeretssian Karine Doiron Kirk S.B. Bergstrom Christian R. McIntire Philippe M. LeBlanc Charles Meunier Claire Turbide Philippe Gros Nicole Beauchemin Bruce A. Vallance Maya Saleh | 2010 | Immunity2010，，3： | 2 |
| 8 | Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn’s disease in mice显示文摘 | Jean Guy LeBlanc Silvina del Carmen Anderson Miyoshi Vasco Azevedo Fernando Sesma Philippe Langella Luis G. Bermúdez-Humarán Laurie Watterlot Gabriela Perdigon Alejandra de Moreno de LeBlanc | 2010 | Journal of Biotechnology2010，，3： | 2 |
| 9 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 10 | Ultrasonic pretreatment of sludge: A review显示文摘 | Sridhar Pilli Puspendu Bhunia Song Yan R.J. LeBlanc R.D. Tyagi R.Y. Surampalli | 2010 | Ultrasonics - Sonochemistry2010，，1： | 2 |
| 11 | Diffusive and convective solute clearances during continuous renal replacement therapy at various dialysate and ultrafiltration flow rates 显示文摘 | Brunet S Leblanc M Geadah D | 1999 | Am J Kidney Dis1999，34，： | 2 |
| 12 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 13 | Endoscopic Ultrasound–Guided Fine-Needle Aspiration of Ascites显示文摘 | John DeWitt Julia LeBlanc Lee McHenry Kathy McGreevy Stuart Sherman | 2007 | Clinical Gastroenterology and Hepatology2007，，5： | 2 |
| 14 | Laparoscopic Versus Open Surgery for Rectal Cancer: Long-Term Oncologic Results显示文摘 | Christophe Laurent Fabien Leblanc Philippe Wütrich Mathieu Scheffler Eric Rullier | 2009 | Annals of Surgery2009，，： | 2 |
| 15 | Comparing prediction power and stability of broadband and hyperspectral vegetation indices for estimation of green leaf area index and canopy chlorophyll density显示文摘 | N.H Broge E Leblanc | 2001 | Remote Sensing of Environment2001，，2： | 2 |
| 16 | An efficient approach to solving the road network equilibrium traffic assignment problem显示文摘 | LeBlanc L J Morlok E K Pierskalla W P | 1975 | Transportation Research1975，9，3： | 2 |
| 17 | Myoglobin clearance and removal during continuous venovenous hemofilt ration 显示文摘 | Amyot SL Leblanc M Thibeault Y | 1999 | Intensive Care Med1999，25，10： | 1 |
| 18 | Laparoseopic repair of parastomal hernias: early results 显示文摘 | Leblanc KA Bellanger DE Whitaker JM | 2002 | J Am Coll Surg2002，194，3： | 1 |
| 19 | Zinc availability and alkaline phosphatase activity in Emiliania huxleyi: Implications for Zn-P co-llmitation in the ocean 显示文摘 | Shaked Y Xu Y Leblanc K | 2006 | Limnology and Oceanography2006，51，： | 1 |
| 20 | Evaluation of national and global LAI products derived from optical remote sensing instruments over Canada显示文摘 | Abuelgasim A A Fernandes R A Leblanc S G | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，7： | 1 |
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