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| 1 | EFFECTS OF RADIX ANGELICAE SINENSIS AND SHUANGHUANGLIAN ON A RAT MODEL OF CHRONIC PSEUDOMONAS AERUGINOSA PNEUMONIA显示文摘Objective. To study the effects of two kinds of Chinese herbal medicine, Radix angelicae sinensis(RAS)(当归)and Shuanghuanglian(SHL)(双黄连) on chronic Pseudomonas aeruginosa(PA)lung infection in a rat model mimicking cystic fibrosis(CF). Methods.Rats were divided into RAS, SHL and control groups. All rats were challenged intratracheally with alginate embedded PA and the treatments with herbal medicine started on the same day of challenge. The drugs were administered subcutaneously once a day for ten days and the control group was treated with sterile saline.The rats were sacrificed two weeks after challenge. Results. Significantly improved lung bacterial clearance(P<005, P<001) and milder macroscopic lung pathology (P<0005) were found in the two treated groups compared to the control group. In the SHL treated group, the neutrophil percent in the peripheral blood leukocytes(P<005), the antiPA IgG level in serum (P<005), the incidence of lung abscesses(P<0005) and the incidence of acute lung inflammation(P<005) were significantly lower than in the control group. The RAS treatment reduced fever(P<005), decreased the incidence of lung abscesses(P<0005) and lung mast cell number (P<005), and lowered antiPA IgG1 level in serum(P<005) when compared to the control group. The antiPA bacterial activity test in SHL was weakly positive whereas in RAS it was negative. Conclusion.The treatment with both herbal medicines could increase the resistance of the rats against PA lung infection and they therefore might be potential promising drugs for stimulation of the immune system in CF patients with chronic PA lung infection. | H.K.Johansen C.Moser V.Faber A.Khamzmi J.Rygaard N.Hφiby Z.J.Song | 2000 | Chinese Medical Sciences Journal2000，15，2： | 7 |
| 2 | Staging of brain pathology related to sporadic Parkinson’s disease显示文摘 | Heiko Braak Kelly Del Tredici Udo Rüb Rob A.I de Vos Ernst N.H Jansen Steur Eva Braak | 2002 | Neurobiology of Aging2002，，2： | 2 |
| 3 | Comparing prediction power and stability of broadband and hyperspectral vegetation indices for estimation of green leaf area index and canopy chlorophyll density显示文摘 | N.H Broge E Leblanc | 2001 | Remote Sensing of Environment2001，，2： | 2 |
| 4 | Sacral nerve stimulation for neurogenic faecal incontinence显示文摘 | B.Holzer H. R.Rosen G.Novi C.Ausch N.H?lbling R.Schiessel | 2007 | Br J Surg2007，，6： | 1 |
| 5 | Micro-powder injection molding显示文摘 | Z.Y Liu N.H Loh S.B Tor K.A Khor Y Murakoshi R Maeda T Shimizu | 2002 | Journal of Materials Processing Tech2002，，2： | 1 |
| 6 | The auditor-audit firm relationship and its effect on burnout and turnover intention显示文摘 | David N.H James J.L | | 0，，04： | 1 |
| 7 | Sustainability assessment of a hybrid energy system显示文摘 | Afgan N.H Carvalho M.G | | 0，，08： | 1 |
| 8 | Holocenc sea level fluctuation on Western Indian continental margin:an update显示文摘 | Hashimi N.H Nigam R Nair R.R Rajagopalan G | | 0，，： | 1 |
| 9 | The origin of colour in raw sugar显示文摘 | Paton N.H | | 0，，： | 1 |
| 10 | Thermal abatement of nitrogen-containing hydrocarbosn by non-catalytic supercritical water oxidation (S CWO)显示文摘 | Al-Duri B LPinto N.H Ashraf-Ball | | 0，，4： | 1 |
| 11 | Developing a performance-based assessment of students' critical thinking skills显示文摘 | Blattner N.H C.L.Frazier | | 0，，01： | 1 |
| 12 | Differential gene expression profile in hepatopancreas of WSSV-resistant shrimp(Penaeus japonicus)by suppression subtractive hybridization显示文摘 | Pan D He N.H Yang Z.Y Liu H.P and Xu X | | 0，，： | 1 |
| 13 | Production of saxitoxin by cultures of Gonyaulax catenella显示文摘 | Proctor N.H Chan S L Trevor A J | | 0，，01： | 1 |
| 14 | A comparison of two methods used to evaluate thermal conductivity for some soils显示文摘 | N.H Abu-Hamdeh A.I Khdair R.C Reeder | 2001 | International Journal of Heat and Mass Transfer2001，，： | 1 |
| 15 | Psychological symptoms of Turkish children and adolescents after the 1999earthquake:Exposure,gender,location,and time duration显示文摘 | Sahin N.H Batigün A.D Yilmaz B | | 0，，03： | 1 |
| 16 | Does Function Follow Organizational Form Evidence from the Lending Practices of Large and Small Banks显示文摘 | Bergera A.N Millerb N.H Petersenc M.A Rajand R.G Steine J.C | | 0，，02： | 1 |
| 17 | A computer modeling study of the in-hibiting effect of organic adsorbates on calcite crystal growth显示文摘 | Leeuw N.H Cooper T.G | | 0，，1： | 1 |
| 18 | The gaze selects informative details within picture显示文摘 | Mackwoah N.H Morandi A.J | | 0，，11： | 1 |
| 19 | 查看详情显示文摘 | You N.H Higashihara T Ando S Ueda M | | 0，，： | 1 |
| 20 | Ultrasound as a catalyzer of aqueous reaction systems: the state of the art and environmental applications显示文摘 | N.H Ince G Tezcanli R.K Belen ?.G Apikyan | 2001 | Applied Catalysis B Environmental2001，，3： | 1 |
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