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| 1 | Modulating Wnt signaling to improve cell replacement therapy for Parkinson's disease显示文摘临床的试用为多巴胺神经原表明了能力,宫外地移植了进 striatum 到 structurallyintegrate ,恢复多巴胺传播,并且导致长期的功能的好处因为 Parkinson 是疾病( PD ) patients.Despite 原则的这个证明,很多限制在 thepast 上妨碍了房间代替治疗的开发 20 年,特别地主机大脑的织物可获得性,接枝幸存,和足够的神经分布。与在优先的临床的试用的失败的 greaterunderstanding,增加了中脑多巴胺的知识开发(包括 Wnts 的现在) ,和 pluripotent 干细胞技术的发展,我们更好比平常被装备使重新致力很多 thesechallenges。这评论为 PD 在房间代替治疗总结试用,磨难,和进步。我们讨论正规的 modulating 和发信号改进在 dopamineneural 开发和成年大脑在他们的角色之上基于的房间治疗的不在经典中的 Wnt 的 theprospects。这将包括 Wnts 的潜力到(i) 在 vitro 和后面的移植扩展胎儿地导出的织物,(ii ) 支持 pluripotent 干细胞的区别,(iii ) 增加神经电路的接枝 integrationand 恢复,并且(iv ) 最后提高接枝幸存。 | Clare L. Parish Lachlan H. Thompson | 2014 | Journal of Molecular Cell Biology2014，8，1： | 5 |
| 2 | Variable retention harvesting in Victoria’s Mountain Ash (Eucalyptus regnans) forests (southeastern Australia)显示文摘Variable retention harvesting is a silvicultural system that focuses on retaining key elements of stand structure at the time of logging and is increasingly being used worldwide.We describe the design and establishment of a variable retention harvesting experiment established in the Mountain Ash(Eucalyptus regnans)forests of the Central Highlands of Victoria,south-eastern Australia.The experiment was instigated in 2003,and the work to date has shown that it has environmental benefits for certain groups of small mammals,birds,and vascular plants.The experiment has been integrated with an ongoing long-term monitoring program as well as other experiments such as those in post-fire salvage-logged areas.Collectively,the results of various studies suggest that the potential value of variable retention harvesting extends beyond green-tree logging to post-fire salvage logging environments.We outline some of the challenges in,and new perspectives derived from,implementing and maintaining our experiment.This included difficulties protecting islands from high-intensity post-harvest regeneration burns and threat of declining funding undermining ongoing project viability.A critically important perspective concerns the ecological and economic context in which variable retention harvesting is implemented.In the particular case of Mountain Ash forests,assessments using formal IUCN criteria classify the ecosystem as being Critically Endangered under the Red Listed Ecosystem approach.As a result,Mountain Ash forests are at a high risk of ecosystem collapse.Further logging will increase that risk,making the basis for continued harvesting questionable.In addition,economic analyses suggest that the value of natural assets,like water production,far outweigh the value of the wood products harvested from the Mountain Ash ecosystem,again leading to questions about the viability of ongoing harvesting.We therefore conclude that whilst variable retention harvesting has the potential to contribute to biodiversity conservation in Mountain Ash forests,broader ecological and economic contextual issues(such as the values of competing resources like water yields and the heavily degraded state of the forest)may erode the case for its broader application. | David Lindenmayer David Blair Lachlan McBurney | 2019 | Ecological Processes2019，8，1： | 5 |
| 3 | Intervertebral disc development and disease-related genetic polymorphisms显示文摘The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context. | Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang | 2016 | Genes & Diseases2016，3，3： | 3 |
| 4 | 基于杂波特性的自动跟踪起始试验统计方法(英文)显示文摘二测试统计基于喧嚷特征被导出。一试验当 track-is-on- 喧嚷假设被拒绝时,轨道被证实。当空假设的假设是真的时,一个常数和已知的假轨道率结果。第一个测试统计数值基于喧嚷密度。当到最近的目标山峰的期望的距离是时,目标察觉的高可能性被结果不到期望的距离到最近的喧嚷山峰。第二个测试统计数值基于喧嚷振幅。当目标山峰的期望的振幅比喧嚷山峰的期望的振幅大时,目标察觉的高可能性被结果。基于喧嚷的测试统计的行为与目标可见性方法相比,用模仿的数据。所有轨道开始方法基于概率的数据协会(PDA ) 用轨道 updater 被使用,延长了合并山峰振幅信息,它是可得到的。 | KENNEDY Hugh Lachlan | 2008 | 自动化学报2008，34，3： | 3 |
| 5 | Photodynamic therapy of high grade glioma – long term survival显示文摘 | Stanley S. Stylli Andrew H. Kaye Lachlan MacGregor Megan Howes Priya Rajendra | 2005 | Journal of Clinical Neuroscience2005，，4： | 2 |
| 6 | GPSPiChain-Blockchain and AI based Self-Contained Anomaly Detection Family Security System in Smart Home显示文摘With advancements in technology, personal computing devices are better adapted for and further integrated into people’s lives and homes. The integration of technology into society also results in an increasing desire to control who and what has access to sensitive information, especially for vulnerable people including children and the elderly. With blockchain rise as a technology that can revolutionize the world, it is now possible to have an immutable audit trail of locational data over time. By controlling the process through inexpensive equipment in the home, it is possible to control whom has access to such personal data. This paper presents a block-chain based family security system for outdoor tracking and in-house monitoring of users’ activities via sensors to detect anomalies in users’ daily activities with the integration of Artificial Intelligence (AI). For outdoor tracking the locations of the consenting family members’ smart phones are logged and stored in a private blockchain which can be accessed through a node installed in the family home on a computer. The data for the whereabouts and daily activities of family members stays securely within the family unit and does not go to any third-party organizations. A Self-Organizing Maps (SOM) based smart contract is used for anomaly detection in users’ daily activities in a smart home, which notifies emergency contact or other family members in case of anomaly detection. The approach described in this paper contributes to the development of in-house data processing for outdoor tracking, and daily activities monitoring and prediction without any third-party hardware or software. The system is implemented at a small scale with one miner, two user nodes and several device nodes, as a proof of concept;the technical feasibility is discussed along with the limitations of the system. Further research will cover the integration of the system into a smart-home environment with additional sensors and multiple users, and ethical implementations of tracking, especially of vulnerable people, via the immutability of blockchain. | Ali Raza Lachlan Hardy Erin Roehrer Soonja Yeom Byeong Ho Kang | 2021 | Journal of Systems Science and Systems Engineering2021，30，4： | 2 |
| 7 | Mucosal imaging in colon polyps:New advances and what the future may hold显示文摘An expanding range of advanced mucosal imaging technologies have been developed with the goal of improving the detection and characterization of lesions in the gastrointestinal tract.Many technologies have targeted colorectal neoplasia given the potential for intervention prior to the development of invasive cancer in the setting of widespread surveillance programs.Improvement in adenoma detection reduces miss rates and prevents interval cancer development.Advanced imaging technologies aim to enhance detection without significantly increasing procedural time.Accurate polyp characterisation guides resection techniques for larger polyps,as well as providing the platform for the“resect and discard”and“do not resect”strategies for small and diminutive polyps.This review aims to collate and summarise the evidence regarding these technologies to guide colonoscopic practice in both interventional and non-interventional endoscopists. | Edward John Young Arvinf Rajandran Hamish Lachlan Philpott Dharshan Sathananthan Sophie Fenella Hoile Rajvinder Singh | 2022 | World Journal of Gastroenterology2022，28，47： | 2 |
| 8 | Geometric integration using discrete gradients 显示文摘 | MC LACHLAN R I QUISPEL G R W ROBIDOUX N | 1999 | Phil Trans R Soc Lond A1999，357，： | 1 |
| 9 | Formation of NOx precursors during the pyrolysis of coal and biomass Part Ⅶ Pyrolysis and gasification of cane trash with steam显示文摘 | Fu-Jun Tian Jiang-long Yu Lachlan J Mckenzie | 2005 | Fuel2005，，84： | 1 |
| 10 | Combined immunohistochemical and retrograde tracing reveals little evidence of innervation of the rat dentate gyrus by midbrain dopamine neurons显示文摘尽管中脑多巴胺(mDA ) 的功能的神经解剖学系统很好被描绘了,考虑它的能力刺激海马趾的形成的文学是不一致的。为 dopaminergic 纤维的权威的标记的表示的缺乏例如多巴胺 transporter,在这个区域在马头鱼尾的怪兽有复杂研究。这里,我们使用了 immunohistochemical 技术描绘在老鼠马头鱼尾的怪兽表示纤维网络的酷氨酸 hydroxylase,与结合了后退从有牙齿的回转跟踪由 mDA 神经原为传入的神经分布估计能力。结果几乎显示那在整个马头鱼尾的怪兽的所有酷氨酸 hydroxylase 纤维具有 noradrenergic 显型,当 overlying 外皮包含 dopaminergic 和 noradrenergic 纤维网络时。而且,后退要用体力地从有牙齿的回转跟踪在地点 coeruleus 的标签酷氨酸 hydroxylase-immunoreactive noradrenergic 神经原然而并非 mDA 神经原。 | Charlotte M. Ermine Jordan L. Wright Clare L. Parish Davor Stanic Lachlan H. Thompson | 2016 | Frontiers in Biology2016，11，3： | 1 |
| 11 | Chlorinatedparaffins in indoor air and dust : Concentrations,congenerpatterns, and human exposure显示文摘 | Friden Ulrika E Me Lachlan Michael S Berger Urs | 2011 | Environment International2011，37，7： | 1 |
| 12 | Self-perceived burden in chronic pain : Relevance, prevalence, and predictors 显示文摘 | John K Keith W Lachlan M | 2012 | PAIN2012，153，8： | 1 |
| 13 | An improved link model for window flow control and its application to fast TCP 显示文摘 | Krister Jacobsson Lachlan L Steven H Low | 2009 | IEEE Transactions on Automatic Control2009，54，3： | 1 |
| 14 | Root uptake and translocation of perfluorinated alkyl acids by three hydroponically grown crops显示文摘 | Felizeter S Mc Lachlan MS Voogt PD | 2014 | J Agric Food Chem2014，62，15： | 1 |
| 15 | Avian riboflavin binding protein binds to lipoprotein receptors in association with vitellogenin显示文摘 | Mac Lachlan I Nimpf J Schneider W J | 1994 | J Biol Chem1994，269，24： | 1 |
| 16 | A Comparison of levobupivacaine 0.5% and racemic bupivacaine 0.5% for extradural anesthesia for caesarean section显示文摘 | Kathryne A Faccenda Alison M Simpson Duncan J Henderson Drew Smith Elizabeth M McGrady Lachlan M.M Morrison | 2003 | Regional Anesthesia and Pain Medicine2003，，5： | 1 |
| 17 | From 2D to 3D:the future of surgery?显示文摘 | Mc Lachlan G | 2011 | Lancet2011，378，9800： | 1 |
| 18 | A generalized FAST TCP- scheme 显示文摘 | Yuan C Tan L S Lachlan L H | 2008 | Computer Communications2008，31，14： | 1 |
| 19 | Avian riboflavin binding protein binds to lipoprotein receptors in association with vitellogenin显示文摘 | Mac Lachlan I Nimp fJ Schneider WJ | 1994 | J Biol Chem1994，269，24： | 1 |
| 20 | Detailed clinical and molecular study of 20 females with Xq deletions with special reference to menstruation and fertility显示文摘 | Mercer C L Lachlan K Karcanias A | 2013 | European journal of medical genetics2013，56，1： | 1 |
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