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| 1 | 成人炎症性肠病处理指南显示文摘 | Carter MJ Lobo AJ Travis SP 杨川华 | 2005 | 胃肠病学2005，10，1： | 35 |
| 2 | Impact of mechanical bowel preparation in elective colorectal surgery:A meta-analysis显示文摘AIM To analyse the effect of mechanical bowel preparation vs no mechanical bowel preparation on outcome in patients undergoing elective colorectal surgery.METHODS Meta-analysis of randomised controlled trials and observational studies comparing adult patients receiving mechanical bowel preparation with those receiving no mechanical bowel preparation, subdivided into those receiving a single rectal enema and those who received no preparation at all prior to elective colorectal surgery. RESULTS A total of 36 studies(23 randomised controlled trials and 13 observational studies) including 21568 patients undergoing elective colorectal surgery were included. When all studies were considered, mechanical bowel preparation was not associated with any significant difference in anastomotic leak rates(OR = 0.90, 95%CI: 0.74 to 1.10, P = 0.32), surgical site infection(OR = 0.99, 95%CI: 0.80 to 1.24, P = 0.96), intraabdominal collection(OR = 0.86, 95%CI: 0.63 to 1.17, P = 0.34), mortality(OR = 0.85, 95%CI: 0.57 to 1.27, P = 0.43), reoperation(OR = 0.91, 95%CI: 0.75 to 1.12, P = 0.38) or hospital length of stay(overall mean difference 0.11 d, 95%CI:-0.51 to 0.73, P = 0.72), when compared with no mechanical bowel preparation, nor when evidence from just randomized controlledtrials was analysed. A sub-analysis of mechanical bowel preparation vs absolutely no preparation or a single rectal enema similarly revealed no differences in clinical outcome measures. CONCLUSION In the most comprehensive meta-analysis of mechanical bowel preparation in elective colorectal surgery to date, this study has suggested that the use of mechanical bowel preparation does not affect the incidence of postoperative complications when compared with no preparation. Hence, mechanical bowel preparation should not be administered routinely prior to elective colorectal surgery. | Katie E Rollins Hannah Javanmard-Emamghissi Dileep N Lobo | 2018 | World Journal of Gastroenterology2018，24，4： | 33 |
| 3 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 4 | Chlorophyll, anthocyanin, and gas exchange changes assessed by spectroradiometry in Fragaria chiloensis under salt stress显示文摘Chlorophyll and anthocyanin contents provide a valuable indicator of the status of a plant's physiology, but to be more widely utilized it needs to be assessed easily and non‐destructively. This is particularly evident in terms of assessing and exploiting germplasm for plant‐breeding programs. We report, for the first time, experiments with Fragaria chiloensis(L.)Duch. and the estimation of the effects of response to salinity stress(0, 30, and 60 mmol NaCl/L) in terms of these pigments content and gas exchange. It is shown that both pigments(which interestingly, themselves show a high correlation) give a good indication of stress response. Both pigments can be accurately predicted using spectral reflectance indices(SRI);however, the accuracy of the predictions was slightly improved using multilinear regression analysis models and genetic algorithm analysis. Specifically for chlorophyll content, unlike other species, the use of published SRI gave better indications ofstress response than Normalized Difference Vegetation Index.The effect of salt on gas exchange is only evident at the highest concentration and some SRI gave better prediction performance than the known Photochemical Reflectance Index. This information will therefore be useful for identifying tolerant genotypes to salt stress for incorporation in breeding programs. | Miguel Garriga Jorge B. Retamales Sebastián Romero-Bravo Peter D.S. Caligari Gustavo A. Lobos | 2014 | Journal of Integrative Plant Biology2014，56，5： | 8 |
| 5 | New prospects in the diagnosis and treatment of immune-mediated inner ear disease显示文摘Autoimmune inner ear disease(AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but also in other inner ear disorders that share the same injury mechanism, damage to the inner ear hair cells. AIED also presents many challenges that have still to be overcome. Firstly, access to the inner ear is limited, as many interventions such as biopsies can result in great irreversible damage. Secondly, there are no completely specific markers for AIED. Lack of a definitive diagnosis can result in the treatment of patients not affected with the disease and, therefore, no response. Finally, some patients become refractory to glucocorticoids and new therapies are needed. This review offers an overview of the animal models that have contributed to the understanding of AIED pathophysiology, the value of currently available diagnostic tests, and therapeutic options, with a special focus on new therapies for non responders or patients refractory to glucocorticoids. Among these new options for therapy, biological agents have been tested recently, whereas gene and stem celltherapy may have a role in the future. The intratympanic route of administration avoids the systemic side effects associated with currently used drugs, and may become a more frequent approach in the future. | David R Lobo Jose Ramon García-Berrocal Rafael Ramírez-Camacho | 2014 | World Journal of Methodology2014，4，2： | 7 |
| 6 | Study comparing the clinical profile of complicated cases of Plasmodium falciparum malaria among adults and children显示文摘 | George Peter Alexander Lobo Manuel Anil Shetty | 2011 | Asian Pacific Journal of Tropical Disease2011，，1： | 7 |
| 7 | 羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。 | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent | 2004 | 中国危重病急救医学2004，16，8： | 6 |
| 8 | Intranasal delivery of nanostructured lipid carriers,solid lipid nanoparticles and nanoemulsions:A current overview of in vivo studies显示文摘The management of the central nervous system(CNS)disorders is challenging,due to the need of drugs to cross the blood-brain barrier(BBB)and reach the brain.Among the various strategies that have been studied to circumvent this challenge,the use of the intranasal route to transport drugs from the nose directly to the brain has been showing promising results.In addition,the encapsulation of the drugs in lipid-based nanocarriers,such as solid lipid nanoparticles(SLNs),nanostructured lipid carriers(NLCs)or nanoemulsions(NEs),can improve nose-to-brain transport by increasing the bioavailability and site-specifc delivery.This review provides the state-of-the-art of in vivo studies with lipid-based nanocarriers(SLNs,NLCs and NEs)for nose-to-brain delivery.Based on the literature available from the past two years,we present an insight into the different mechanisms that drugs can follow to reach the brain after intranasal administration.The results of pharmacokinetic and pharmacodynamics studies are reported and a critical analysis of the differences between the anatomy of the nasal cavity of the different animal species used in in vivo studies is carried out.Although the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear,it appears that the intranasal route together with the use of NLCs,SLNs or NEs is advantageous for targeting drugs to the brain.These systems have been shown to be more effective for nose-to-brain delivery than other routes or formulations with non-encapsulated drugs,so they are expected to be approved by regulatory authorities in the coming years. | Cláudia Pina Costa Joao Nuno Moreira JoséManuel Sousa Lobo Ana Catarina Silva | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 9 | Improved performance of UVC-LEDs by combination of high-temperature annealing and epitaxially laterally overgrown AlN/sapphire显示文摘We report on the performance of AlGaN-based deep ultraviolet light-emitting diodes(UV-LEDs)emitting at 265 nm grown on stripe-patterned high-temperature annealed(HTA)epitaxially laterally overgrown(ELO)aluminium nitride(AIN)/sapphire templates.For this purpose,the structural and electro-optical properties of ultraviolet-c light-emitting diodes(UVC-LEDs)on as-grown and on HTA planar AlN/sapphire as well as ELO AlN/sapphire with and without HTA are investigated and compared.Cathodoluminescence measurements reveal dark spot densities of 3.5×10^9 cm^-2,1.1×10^9 cm^-2,1.4×10^9 cm^-2,and 0.9×10^9 cm^-2 in multiple quantum well samples on as-grown planar AIN/sapphire,HTA planar AlN/sapphire,ELO AlN/sapphire,and HTA ELO AlN/sapphire,respectively,and are consistent with the threading dislocation densities determined by transmission electron microscopy(TEM)and high-resolution X-ray diffraction rocking curve.The UVC-LED performance improves with the reduction of the threading dislocation densities(TDDs).The output powers(measured on-wafer in cw operation at 20 mA)of the UV-LEDs emitting at 265 nm were 0.03 mW(planar AlN/sapphire),0.8 mW(planar HTA AlN/sapphire),0.9 mW(ELO AlN/sapphire),and 1.1 mW(HTA ELO AlN/sapphire),respectively.Furthermore,Monte Carlo ray-tracing simulations showed a 15%increase in light-extraction efficiency due to the voids formed in the ELO process.These results demonstrate that HTA ELO AlN/sapphire templates provide a viable approach to increase the efficiency of UV-LEDs,improving both the internal quantum efficiency and the light-extraction efficiency. | NORMAN SUSILO EVIATHAR ZIFFER SYLVIA HAGEDORN LEONARDO CANCELLARA CARSTEN NETZEL NEYSHA LOBO PLOCH SHAOJUN WU JENS RASS SEBASTIAN WALDE LUCA SULMONI MARTIN GUTTMANN TIM WERNICKE MARTIN ALBRECHT MARKUS WEYERS MICHAEL KNEISSL | 2020 | Photonics Research2020，8，4： | 4 |
| 10 | DNA damage-induced cell death: lessons from the central nervous system显示文摘脱氧核糖核酸损坏不能,但是总是,导致房间死亡。当连接脱氧核糖核酸的几条小径损坏信号到线粒体依赖者,独立死亡机械被阐明了时,这些小径的连接由多重其它服从于规定不好的因素理解。我们建议了二个概念的模型解释推迟并且对脱氧核糖核酸的可变房间死亡反应损坏:综合监视对自治小径。在这评论,我们讨论这二个模型怎么可以解释在死亡反应被辐射剂量,房间周期地位和 neuronal 开发调整的地方,离子辐射(红外) 在发展中的中枢神经系统导致的房间死亡的体内规定。 | Helena Lobo Borges Rafael Linden Jean YJ Wang | 2008 | Cell Research2008，18，1： | 4 |
| 11 | Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS ? ) Society Recommendations显示文摘 | U. O. Gustafsson M. J. Scott W. Schwenk N. Demartines D. Roulin N. Francis C. E. McNaught J. MacFie A. S. Liberman M. Soop A. Hill R. H. Kennedy D. N. Lobo K. Fearon O. Ljungqvist | 2013 | World Journal of Surgery2013，，2： | 4 |
| 12 | Current-induced degradation and lifetime prediction of 310 nm ultraviolet light-emitting diodes显示文摘The impact of operation current on the degradation behavior of 310 nm UV LEDs is investigated over 1000 h of stress. It ranges from 50 to 300 mA and corresponds to current densities from 34 to 201 A/cm^2.To separate the impact of current from that of temperature, the junction temperature is kept constant by adjusting the heat sink temperature. Higher current was found to strongly accelerate the optical power reduction during operation. A mathematical model for lifetime prediction is introduced.It indicates that lifetime is inversely proportional to the cube of the current density, suggesting the involvement of Auger recombinati on. | Jan Ruschel Johannes Glaab Batoul Beidoun Neysha Lobo Ploch Jens Rass Tim Kolbe Arne Knauer Markus Weyers Sven Einfeldt Michael Kneissl | 2019 | Photonics Research2019，7，7： | 3 |
| 13 | 不同液体复苏条件下多巴酚丁胺对肠缺血-再灌注休克的疗效比较显示文摘目的 比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 L RS+HES复苏 +多巴酚丁胺治疗组 (L RS+HES+DOB组 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠 I/ R休克模型 ,松夹再灌注时同步进行液体复苏和多巴酚丁胺治疗。观察各时间点血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 )的变化 ,并通过测定动脉二氧化碳间隙〔 Pt a CO2 间隙 =肠黏膜 CO2 分压 (Pt CO2 ) -动脉血 CO2 分压 (Pa CO2 )〕、肠黏膜 p H值 (p Hi)、动脉血乳酸浓度和氧输送 (DO2 )等指标间接评价组织氧合情况。结果 多巴酚丁胺能显著减轻兔肠I/ R休克后平均动脉压、心率、心排血量和肠系膜上动脉血流的下降 ,两多巴酚丁胺治疗组与两复苏组比较 ,差异均有显著性 (P均 <0 .0 5 ) ;且 L RS+HES+DOB组平均动脉压下降程度较 L RS+DOB组明显减轻 (P<0 .0 5 )。与 L RS组比较 ,两多巴酚丁胺治疗组均能明显降低血乳酸浓度和 Pt a CO2 间隙 ,升高 p Hi和 DO2 (P均<0 .0 5 ) ,尤其在 L RS+HES+DOB组效果更显著 (P均 <0 .0 5 ) ,与 L | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo DanielDe Backer 肖献忠 Jean-Louis Vincent | 2005 | 中国危重病急救医学2005，17，2： | 3 |
| 14 | Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS ? ) Society Recommendations显示文摘 | J. Nygren J. Thacker F. Carli K. C. H. Fearon S. Norderval D. N. Lobo O. Ljungqvist M. Soop J. Ramirez | 2013 | World Journal of Surgery2013，，2： | 3 |
| 15 | The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials显示文摘 | Krishna K. Varadhan Keith R. Neal Cornelius H.C. Dejong Kenneth C.H. Fearon Olle Ljungqvist Dileep N. Lobo | 2010 | Clinical Nutrition2010，，4： | 2 |
| 16 | A procedure to assess the spatial variability in the importance of abiotic factors affecting distributions: the case of world freshwater fishes显示文摘 | Ana M. MANJARRES-HERNANDEZ Castor GUISANDE Emilio GARCiA-ROSELLO Patricia PELAYO-VILLAMIL Jacinto GONZALEZ-DAcOSTA Juirgen HEINE Luis GONZALEZ VILAS Carlos GRANADO-LORENClO Santiago R. DUQUE Jorge M. LOBO | 2018 | Current Zoology2018，64，5： | 2 |
| 17 | 利用神经网络模型预测球团矿的冷压强度(英文)显示文摘建立了一个神经网络模型来预测球团矿的冷压强度,该网络模型采用三层前向BP神经网络,网络结构为12-12-1,12个输入变量分别为给料率、料层高度、焙烧温度、干透点温度、COREX煤气单耗、膨润土的添加量、生球水分、生球碳含量以及成品球的FeO、MgO、Al2O3含量和碱度;隐层含有12个神经元;输出为成品球团冷压强度;神经元激活函数选择双曲正切函数;神经网络学习算法使用的是带惯量项的误差反向传播学习算法(BP学习算法)。选取353组数据来训练和测试神经网络,其中247组数据用于训练网络,其余数据用于测试网络。测试结果表明,该网络的预测结果与实际结果的误差在3%以内,同时通过敏感性分析得出以下结论:①膨润土添加量、生球碳含量以及成品球的FeO、MgO、Al2O3含量和碱度对球团矿的冷压强度有重要影响;②增加膨润土添加量、成品球碱度、MgO含量、焙烧温度、干透点温度、COREX煤气单耗有助于改善球团矿的冷压强度;③增加FeO含量、生球碳含量、Al2O3含量、料层高度、给料率将使球团矿的冷压强度迅速下降;④增加生球水分会降低冷压强度;⑤提高球团矿冷压强度的参数设置(膨润土的添加量:0.86%~0.92%;wFeO<0.5%;生球碳含量:1.00%~1.10%;MgO含量:0.39%~0.44%);⑥在0.3~0.7范围内增加碱度不能显著改善球团矿的冷压强度。 | T Umadevi Naveen F Lobo Sangamesh Desai Manjunath Prabhu 黄可为 | 2012 | 世界钢铁2012，12，4： | 2 |
| 18 | Investigation of acute abdomen显示文摘 | Smith JK Lobo DN | 2008 | Surgery(Ox- ford)2008，26，3： | 1 |
| 19 | Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins,coagulation factors,and carbohydrate metabolism显示文摘 | Lobo RA Bush T Carr BR | 2001 | Fertil Steril2001，76，1： | 1 |
| 20 | Analysis of Intensity of Post-stroke Depression and Its Relationship with the Cerebral Lesion Location显示文摘 | GONZALEZ TORRECILLAS JI MENDLEWlCZ J LOBO A | 1997 | Med Clin (Brac)(S0025-7753)1997，109，1： | 1 |
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