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| 1 | 羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。 | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent | 2004 | 中国危重病急救医学2004，16，8： | 6 |
| 2 | Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study显示文摘 | Marc-Jacques Dubois Carlos Orellana-Jimenez Christian Melot Daniel De Backer Jacques Berre Marc Leeman Serge Brimioulle Olivier Appoloni Jacques Creteur Jean-Louis Vincent | 2006 | Critical Care Medicine2006，，： | 2 |
| 3 | Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study显示文摘 | Yasser Sakr Konrad Reinhart Jean-Louis Vincent Charles L. Sprung Rui Moreno V Marco Ranieri Daniel De Backer Didier Payen | 2006 | Critical Care Medicine2006，，3： | 1 |
| 4 | How monitoring of the microcirculation may help US at the bedside : cardiopulmonary monitoring 显示文摘 | Verdant C De Backer S Daniel De | 2005 | Crit Care2005，11，3： | 1 |
| 5 | Lactic acidosis显示文摘 | Daniel De Backer | 2003 | Intensive Care Medicine2003，，5： | 1 |
| 6 | Comparison of dopamine and norepinephrine in the treatment of shock显示文摘 | Daniel De Backer Patrick Biston Jacques Devriendt | 2010 | N Engl J Med2010，362，9： | 1 |
| 7 | Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study显示文摘 | Marc-Jacques Dubois Carlos Orellana-Jimenez Christian Melot Daniel De Backer Jacques Berre Marc Leeman Serge Brimioulle Olivier Appoloni Jacques Creteur Jean-Louis Vincent | 2006 | Critical Care Medicine2006，，10： | 1 |
| 8 | Comparison of Dopamine and Norepinephrine in the Treatment of Shock显示文摘 | Daniel De Backer Patrick Biston Jacques Devriendt | 2010 | N Engl J Med2010，362，24： | 1 |
| 9 | Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best?*显示文摘 | Daniel De Backer Jacques Creteur Eliézer Silva Jean-Louis Vincent | 2003 | Critical Care Medicine2003，，6： | 1 |
| 10 | Comparison of dopamine and norepinephrine in the treatment of shock显示文摘 | Daniel De Backer Patrick Biston Jacques Devriendt | 2010 | N Engl Med2010，362，： | 1 |
| 11 | Novelties in the evaluation of microcirculation in septic shock显示文摘Microvascular alterations were first described in critically ill patients about 20 years ago. These alterations are characterized by a decrease in vascular density and presence of non-perfused capillaries close to well-perfused vessels. In addition, heterogeneity in microvascular perfusion is a key finding in sepsis. In this narrative review, we report our actual understanding of microvascular alterations, their role in the development of organ dysfunction, and the implications for outcome. Herein, we discuss the state of the potential therapeutic interventions and the potential impact of novel therapies. We also discuss how recent technologic development may affect the evaluation of microvascular perfusion. | Daniel De Backer | 2023 | Journal of Intensive Medicine2023，3，2： | 0 |
| 12 | 从欧洲经验看重症医学专科建设之路显示文摘ICU专科培训模式孰优孰劣 开放式ICU指以原所在科室的医生为主,ICU医生只提供治疗建议;封闭式ICU则完全是由ICU医生负责。多项研究显示,ICU由开放式变为封闭式管理后,患者病死率明显下降,所以临床需要ICU专科医生,但是成为ICU医生需要经过专科培训。 | Daniel De Backer | 2013 | 中华医学信息导报2013，，11： | 0 |
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