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| 1 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 2 | Diabetic heart disease:A clinical update显示文摘Diabetes mellitus(DM) significantly increases the risk of heart disease,and DMrelated healthcare expenditure is predominantly for the management of cardiovascular complications.Diabetic heart disease is a conglomeration of coronary artery disease(CAD),cardiac autonomic neuropathy(CAN),and diabetic cardiomyopathy(DCM).The Framingham study clearly showed a 2 to 4-fold excess risk of CAD in patients with DM.Pathogenic mechanisms,clinical presentation,and management options for DM-associated CAD are somewhat different from CAD among nondiabetics.Higher prevalence at a lower age and more aggressive disease in DM-associated CAD make diabetic individuals more vulnerable to premature death.Although common among diabetic individuals,CAN and DCM are often under-recognised and undiagnosed cardiac complications.Structural and functional alterations in the myocardial innervation related to uncontrolled diabetes result in damage to cardiac autonomic nerves,causing CAN.Similarly,damage to the cardiomyocytes from complex pathophysiological processes of uncontrolled DM results in DCM,a form of cardiomyopathy diagnosed in the absence of other causes for structural heart disease.Though optimal management of DM from early stages of the disease can reduce the risk of diabetic heart disease,it is often impractical in the real world due to many reasons.Therefore,it is imperative for every clinician involved in diabetes care to have a good understanding of the pathophysiology,clinical picture,diagnostic methods,and management of diabetes-related cardiac illness,to reduce morbidity and mortality among patients.This clinical review is to empower the global scientific fraternity with up-to-date knowledge on diabetic heart disease. | Jake Rajbhandari Cornelius James Fernandez Mayuri Agarwal Beverly Xin Yi Yeap Joseph M Pappachan | 2021 | World Journal of Diabetes2021，12，4： | 8 |
| 3 | 具有高测量重复性的脉冲磁场磁强计显示文摘脉冲磁场磁强计是一种新的、高效率、全象限的永磁材料测量仪器。对脉冲磁场磁强计的磁场产生、信号采集和数据处理等原理分别进行了阐述。由于磁体不必与极头构成闭合回路,在采用珀尔帖效应精确控制测试线圈的环境温度以后,脉冲磁场磁强计的测量重复性(重复9次)由原来的0.326%(Br)、1.860%(HcJ),提高到了恒温慢速测量模式下的0.081 9%(Br)、0.080 8%(HcJ)。 | 林安利 贺建 张跃 John Dudding Robin Cornelius Paul Knell | 2008 | 计量学报2008，29，4： | 5 |
| 4 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 5 | Effect of sedative agent selection on morbidity, mortality and length of stay in patients with increase in intracranial pressure显示文摘BACKGROUND: To identify the effects of sedative agent selection on morbidity, mortality, and length of stay in patients with suspected increase in intracranial pressure. Recent trends and developments have resulted in changes to medications that were previously utilized as pharmacological adjuncts in the sedation and intubation of patients with suspected increases in intracranial pressure. Medications that were previously considered contraindicated are now being used with increasing regularity without demonstrated safety and effectiveness. The primary objective of this study is to evaluate and compare the use of Ketamine as an induction agent for patients with increased intracranial pressure. The secondary objective was to evaluate and compare the use of Etomidate, Midazolam, and Ketamine in patients with increased intracranial pressure. METHODS: We conducted a retrospective chart review of patients transported to our facility with evidence of intracranial hypertension that were intubated before trauma center arrival. Patients were identifi ed during a 22-month period from January 2014 to October 2015. Goals were to evaluate the impact of sedative agent selection on morbidity, mortality, and length of stay.RESULTS: During the review 148 patients were identifi ed as meeting inclusion criteria, 52 were excluded due to incomplete data. Of those the patients primarily received; Etomidate, Ketamine, and Midazolam. Patients in the Ketamine group were found to have a lower mortality rate after injury stratifi cation. CONCLUSION: Patients with intracranial hypertension should not be excluded from receiving Ketamine during intubation out of concern for worsening outcomes. | Brian G.Cornelius Elizabeth Webb Angela Cornelius Kenneth W.G.Smith Srdan Ristic Jay Jain Urska Cvek Marjan Trutschl | 2018 | World Journal of Emergency Medicine2018，9，4： | 4 |
| 6 | 浸没式PVDF超滤膜在大型再生水厂的中试研究显示文摘将浸没式PVDF超滤膜应用于美国West Basin再生水厂的中试系统,在同一进水水质和运行条件下,考察其与水厂现有浸没式PP超滤膜系统在市政污水处理系统的运行效果和清洗效果。结果表明:在9个月的连续运行过程中,与水厂现有系统的浸没式PP超滤膜相比,浸没式PVDF超滤膜可在原系统PP膜组件2. 28倍运行通量的条件下稳定运行,跨膜压差稳定在13. 8~82. 7 kPa;产水水质更好,产水浊度小于0. 1 NTU,且运行风险更小;具有良好的机械性能,运行9个月零断丝或破损。 | 何柳东 林亚凯 闫博 安康 Poschmann Tom Cornelius Jan | 2019 | 中国给水排水2019，35，1： | 3 |
| 7 | Super-resolution of geosynchronous synthetic aperture radar images using dialectical GANs显示文摘Dear editor,The concept of geosynchronous synthetic aperture radar (GEO SAR) system was conceived in an effort to realize a quick observation of emergency disasters (e.g., landslides and earthquakes)[1].The novel GEO SAR system has the significant advantages of short-revisit time and large coverage and facilitates the nearly continuous observation of target regions, unlike the currently operatinglow earth orbit (LEO) SARs [2]. | Yuanhao LI Dongyang AO Corneliu Octavian DUMITRU Cheng HU Mihai DATCU | 2019 | Science China(Information Sciences)2019，62，10： | 3 |
| 8 | Multimodality treatment strategies have changed prognosis of peritoneal metastases显示文摘For a long time, treatment of peritoneal metastases(PM) was mostly palliative and thus, this status was link with 'terminal status/despair'. The current multimodal treatment strategy, consisting of cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC), has been strenuously achieved over time, but seems to be the best treatment option for PM patients. As we reviewed the literature data, we could emphasize some milestones and also, controversies in the history of proposed multimodal treatment and thus, outline the philosophy of this approach, which seems to be an unusual one indeed. Initially marked by nihilism and fear, but benefiting from a remarkable joint effort of human and material resources(multi-center and-institutional research), over a period of 30 years, CRS and HIPEC found their place in the treatment of PM. The next 4 years were dedicated to the refinement of the multimodal treatment, by launching research pathways. In selected patients, with requires training, it demonstrated a significant survival results(similar to the Hepatic Metastases treatment), with acceptable risks and costs. The main debates regarding CRS and HIPEC treatment were based on the oncologists' perspective and the small number of randomized clinical trials. It is important to statement the PM patient has the right to be informed of the existence of CRS and HIPEC, as a real treatment resource, the decision being made by multidisciplinary teams. | corneliu lungoci aurel ion mironiuc valentin muntean traian oniu hubert leebmann max mayr pompiliu piso | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 2 |
| 9 | The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials显示文摘 | Krishna K. Varadhan Keith R. Neal Cornelius H.C. Dejong Kenneth C.H. Fearon Olle Ljungqvist Dileep N. Lobo | 2010 | Clinical Nutrition2010，，4： | 2 |
| 10 | Up to 70 THz bandwidth from an implanted Ge photoconductive antenna excited by a femtosecond Er:fibre laser显示文摘Phase-stable electromagnetic pulses in the THz frequency range offer several unique capabilities in time-resolved spectroscopy.However,the diversity of their application is limited by the covered spectral bandwidth.In particular,the upper frequency limit of photoconductive emitters-the most widespread technique in THz spectroscopy-reaches only up to 7 THz in the regular transmission mode due to absorption by infrared-active optical phonons.Here,we present ultrabroadband(extending up to 70 THz)THz emission from an Au-implanted Ge emitter that is compatible with mode-locked fibre lasers operating at wavelengths of 1.1 and 1.55μm with pulse repetition rates of 10 and 20 MHz,respectively.This result opens up the possibility for the development of compact THz photonic devices operating up to multi-THz frequencies that are compatible with Si CMOS technology. | Abhishek Singh Alexej Pashkin Stephan Winnerl Malte Welsch Cornelius Beckh Philipp Sulzer Alfred Leitenstorfer Manfred Helm Harald Schneider | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 11 | Treatment-Induced Cortical Reorganization After Stroke in Humans显示文摘 | Joachim Liepert Heike Bauder Wolfgang H. R. Miltner Edward Taub Cornelius Weiller | 2000 | Stroke: Journal of the American Heart Association2000，，6： | 2 |
| 12 | Epidemiological link between obesity,type 2 diabetes mellitus and cancer显示文摘There exists a complex interaction between obesity,type 2 diabetes mellitus(T2DM)and cancer,and an increase in the incidence of cancer is expected with the growing obesity-diabetes pandemic.The association of cancer with diabetes mellitus and obesity appears to be site-specific,the highest risk being for postmenopausal breast cancer,endometrial cancer,and colorectal cancer.Moreover,there is worsening of hyperglycaemia with the onset of cancer,evidencing a bidirectional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer survivors.In this review,we look at the epidemiological evidence from observational studies and Mendelian randomization studies linking obesity,diabetes,and cancer,as well as the complex pathophysiological mechanisms involved,including insulin resistance with associated hyperinsulinaemia,the effect of chronic low-grade inflammation,and the effect of various adipokines that are associated with obesity and T2DM.Additionally,we describe the novel therapeutic strategies,based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis. | Cornelius J Fernandez Annu Susan George Nikhila A Subrahmanyan Joseph M Pappachan | 2021 | World Journal of Methodology2021，11，3： | 2 |
| 13 | Analysis of radiation-induced liver disease using the Lyman NTCP model显示文摘 | Laura A. Dawson Daniel Normolle James M. Balter Cornelius J. McGinn Theodore S. Lawrence Randall K. Ten Haken | 2002 | International Journal of Radiation Oncology, Biology, Physics2002，，： | 2 |
| 14 | Discrepancies in the clinical and radiological profiles of COVID-19:A case-based discussion and review of literature显示文摘The current gold standard for the diagnosis of coronavirus disease-19(COVID-19)is a positive reverse transcriptase polymerase chain reaction(RT-PCR)test,on the background of clinical suspicion.However,RT-PCR has its limitations;this includes issues of low sensitivity,sampling errors and appropriate timing of specimen collection.As pulmonary involvement is the most common manifestation of severe COVID-19,early and appropriate lung imaging is important to aid diagnosis.However,gross discrepancies can occur between the clinical and imaging findings in patients with COVID-19,which can mislead clinicians in their decision making.Although chest X-ray(CXR)has a low sensitivity for the diagnosis of COVID-19 associated lung disease,especially in the earlier stages,a positive CXR increases the pre-test probability of COVID-19.CXR scoring systems have shown to be useful,such as the COVID-19 opacification rating score which helps to predict the need of tracheal intubation.Furthermore,artificial intelligence-based algorithms have also shown promise in differentiating COVID-19 pneumonia on CXR from other lung diseases.Although costlier than CXR,unenhanced computed tomographic(CT)chest scans have a higher sensitivity,but lesser specificity compared to RT-PCR for the diagnosis of COVID-19 pneumonia.A semi-quantitative CT scoring system has been shown to predict short-term mortality.The routine use of CT pulmonary angiography as a first-line imaging modality in patients with suspected COVID-19 is not justifiable due to the risk of contrast nephropathy.Scoring systems similar to those pioneered in CXR and CT can be used to effectively plan and manage hospital resources such as ventilators.Lung ultrasound is useful in the assessment of critically ill COVID-19 patients in the hands of an experienced operator.Moreover,it is a convenient tool to monitor disease progression,as it is cheap,non-invasive,easily accessible and easy to sterilise.Newer lung imaging modalities such as magnetic resonance imaging(MRI)for safe imaging among children,adolescents and pregnant women are rapidly evolving.Imaging modalities are also essential for evaluating the extra-pulmonary manifestations of COVID-19:these include cranial imaging with CT or MRI;cardiac imaging with ultrasonography(US),CT and MRI;and abdominal imaging with US or CT.This review critically analyses the utility of each imaging modality to empower clinicians to use them appropriately in the management of patients with COVID-19 infection. | Hemant Kumar Cornelius James Fernandez Sangeetha Kolpattil Mohamed Munavvar Joseph M Pappachan | 2021 | World Journal of Radiology2021，13，4： | 2 |
| 15 | Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States显示文摘AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD. | Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 16 | Influence of Iodine-^131 Dose on the Outcome of Hyperthyroidism in Children显示文摘 | Rivkees SA Cornelius EA | 2003 | PEDIATRICS2003，111，4： | 1 |
| 17 | In vitro generation of islets in long term cultures of pluripotent stem cells from adult mouse pancreas显示文摘 | Tchernev V Kao K J | 1997 | Horm Metab Res1997，29，6： | 1 |
| 18 | Clustering cultivars into groups without rank2change interactions显示文摘 | Cornelius P L van Sanford D A Seyetsadr M S | 1992 | Crop1992，24，： | 1 |
| 19 | Reinnervation-induced alterations in rat skeletal muscle显示文摘 | Zhou Z Cornelius C P Eichner M | 2006 | Neurobiol Dis2006，23，： | 1 |
| 20 | Modified Judet approach and minifragment fixation of scapular body and glenoid neck fractures显示文摘 | Jones CB Cornelius JP Sietseraa DL | | J Orthop Trauma0，23，55： | 1 |
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