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| 1 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 2 | Update on the management of pancreatic cancer:Surgery is not enough显示文摘Pancreatic ductal adenocarcinoma(PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%.Only about 15% of the patients present with a resectable PDAC with potential to undergo 'curative' surgery.After surgery,local and systemic recurrence,is though very common.The median survival of resected patients with adjuvant chemotherapy after surgery is only 20-23 mo.This underscores the significant need to improve PDAC management strategies.Increased survival rate is dependent on new breakthroughs in our understanding of not at least tumor biology.The aim of this review is to update and comment on recent knowledge concerning PDAC biology and new diagnostics and treatment modalities.One fundamental approach to improve survival rates is by earlier and improved diagnosis of the disease.In recent years,novel blood-based biomarkers have emerged based on genetic,epigenetic and protein changes in PDAC with very promising results.For biomarkers to enter clinical practice they need to have been developed using adequate control groups and provide high sensitivity and specificity and by this identify patients at risk already in a pre-symptomatic stage.Another way to improve outcomes,is by employing neoadjuvant treatments thereby increasing the number of resectable cases.Novel systemic treatment regimes like FOLFIRINOX and nab-paclitaxel have demonstrated improvements in prolonging survival in advanced cases,but long-term survival is still scarce.The future improved understanding of PDAC biology will inevitably render new treatment options directed against both the cancer cells and the surrounding microenvironment. | Daniel Ansari Adam Gustafsson Roland Andersson | 2015 | World Journal of Gastroenterology2015，21，11： | 18 |
| 3 | The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors显示文摘 | Ben Lawrence Bjorn I. Gustafsson Anthony Chan Bernhard Svejda Mark Kidd Irvin M. Modlin | 2011 | Endocrinology and Metabolism Clinics of North America2011，，1： | 6 |
| 4 | High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation显示文摘AIM: To study whether patients with excess deoxycholic acid (DCA) differ from those with normal percentage of DCA with respect to biliary lipid composition and cholesterol saturation of gallbladder bile.METHODS: Bile was collected during operation through puncturing into the gallbladder from 122 cholesterol gallstone patients and 46 gallstone-free subjects undergoing cholecystectomy. Clinical data, biliary lipids, bile acid composition,presence of crystals and nucleation time were analyzed.RESULTS: A subgroup of gallstone patients displayeda higher proportion of DCA in bile than gallstone free subjects.By choosing a cut-off level of the 90th percentile, a group of 13 gallstone patients with high DCA levels (mean 50percent of total bile acids) and a large group of 109 patients with normal DCA levels (mean 21 percent of total bile acids)were obtained. The mean age of the patients with high DCA levels was higher than that of the group with normal levels (mean age: 62 years vs45 years) and so was the mean BMI (28.3 vs. 24.7). Plasma levels of cholesterol and triglycerides were slightly higher in the DCA excess groups compared with those in the normal DCA group. There was no difference in biliary lipid composition, cholesterol saturation, nucleation time or occurrence of cholesterol crystals in bile between patients with high and normal levels of DCA.CONCLUSION: Gallstone patients with excess DCA were of older age and had higher BMI than patients with normal DCA. The two groups of patients did not differ with respect to biliary lipid composition, cholesterol saturation, nucleation time or occurrence of cholesterol crystals. It is concluded that DCA in bile does not seem to contribute to gallstone formation in cholesterol gallstone patients. | Ulf Gustafsson Staffan Sahlin Curt Einarsson | 2003 | World Journal of Gastroenterology2003，9，7： | 5 |
| 5 | Codon bias and heterologous protein expression显示文摘 | Claes Gustafsson Sridhar Govindarajan Jeremy Minshull | 2004 | Trends in Biotechnology2004，，7： | 4 |
| 6 | Experimental analysis of tip vortex cavitation mitigation by controlled surface roughness显示文摘This study presents results of experiments where roughness applications are evaluated in delaying the tip vortex cavitation inception of an elliptical foil.High-speed video recordings and laser doppler velocimetry(LDV)measurements are employed to provide further details on the cavitation behavior and tip vortex flow properties in different roughness pattern configurations.The angular momentum measurements of the vortex core region at one chord length downstream of the tip indicate that roughness leads to a lower angular momentum compared with the smooth foil condition while the vortex core radius remains similar in the smooth and roughened conditions.The observations show that the cavitation number for tip vortex cavitation inception is reduced by 33%in the optimized roughness pattern compared with the smooth foil condition where the drag force increase is observed to be around 2%.During the tests,no obvious differences in the cavitation inception properties of uniform and non-uniform roughness distributions are observed.However,the drag force is found to be higher with a non-uniform roughness distribution. | Urban Svennberg Abolfazl Asnaghi Robert Gustafsson Rickard E.Bensow | 2020 | Journal of Hydrodynamics2020，32，6： | 4 |
| 7 | Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS ? ) Society Recommendations显示文摘 | U. O. Gustafsson M. J. Scott W. Schwenk N. Demartines D. Roulin N. Francis C. E. McNaught J. MacFie A. S. Liberman M. Soop A. Hill R. H. Kennedy D. N. Lobo K. Fearon O. Ljungqvist | 2013 | World Journal of Surgery2013，，2： | 4 |
| 8 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 3 |
| 9 | 森林土壤中硫、硒、砷的吸持机理及其固相形态(下)显示文摘二、材料和方法(一)供试土壤供试土样,来自斯堪的纳维亚不同地区针叶林植被下一百个样点的土壤.研究土壤明显地灰化,发育在相对弱风化、粗质地的土壤母质上(主要为冰碛物).另有一个用于硒实验室研究的土壤是发育于石灰质冰碛物上的幼年土。 | Jon Petter Gustafsson 王美珠 | 1995 | 土壤学进展1995，23，5： | 2 |
| 10 | Role of apoptosis in cardiovascular disease显示文摘 | Youngil Lee ?sa B. Gustafsson | 2009 | Apoptosis2009，，4： | 2 |
| 11 | Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system显示文摘The development of Drug Delivery Systems(DDS)has led to increasingly efficient therapies for the treatment and detection of various diseases.DDS use a range of nanoscale delivery platforms produced from polymeric of inorganic materials,such as micelles,and metal and polymeric nanoparticles,but their variant chemical composition make alterations to their size,shape,or structures inherently complex.Genetically encoded protein nanocages are highly promising DDS candidates because of their modular composition,ease of recombinant production in a range of hosts,control over assembly and loading of cargo molecules and biodegradability.One example of naturally occurring nanocompartments are encapsulins,recently discovered bacterial organelles that have been shown to be reprogrammable as nanobioreactors and vaccine candidates.Here we report the design and application of a targeted DDS platform based on the Thermotoga maritima encapsulin reprogrammed to display an antibody mimic protein called Designed Ankyrin repeat protein(DARPin)on the outer surface and to encapsulate a cytotoxic payload.The DARPin9.29 chosen in this study specifically binds to human epidermal growth factor receptor 2(HER2)on breast cancer cells,as demonstrated in an in vitro cell culture model.The encapsulin-based DDS is assembled in one step in vivo by co-expressing the encapsulin-DARPin9.29 fusion protein with an engineered flavin-binding protein mini-singlet oxygen generator(MiniSOG),from a single plasmid in Escherichia coli.Purified encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis,indicating that the system is functional and specific.The DDS is modular and has the potential to form the basis of a multi-receptor targeted system by utilising the DARPin screening libraries,allowing use of new DARPins of known specificities,and through the proven flexibility of the encapsulin cargo loading mechanism,allowing selection of cargo proteins of choice. | Alexander Van de Steen Rana Khalife Noelle Colant Hasan Mustafa Khan Matas Deveikis Saverio Charalambous Clare M.Robinson Rupali Dabas Sofia Esteban Serna Diana A.Catana Konstantin Pildish Vladimir Kalinovskiy Kenth Gustafsson Stefanie Frank | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 2 |
| 12 | Slip-based tire-road friction estimation显示文摘 | Fredrik Gustafsson | 1997 | Automatica1997，，6： | 2 |
| 13 | Increased expression of vascular endothelial growth factor in human skeletal muscle in response to short-term one-legged exercise training显示文摘 | Gustafsson T Knutsson A Puntschart A | 2002 | Pflugers Arch-Eur J Physiol2002，444，： | 2 |
| 14 | Individualized prediction of risk of metachronous peritoneal carcinomatosis from colorectal cancer显示文摘 | J. Segelman O. Akre U. O. Gustafsson M. Bottai A. Martling | 2014 | Colorectal Dis2014，，5： | 2 |
| 15 | Flexible light-emitting diodes made from soluble conducting polymers显示文摘 | Gustafsson G Cao Y Treacy G M | 1992 | Nature1992，357，6378： | 2 |
| 16 | Instrumental variable subspace tracking using projection approximation显示文摘 | Gustafsson T | 1998 | IEEE Transactions on Signal Processing1998，46，3： | 1 |
| 17 | The uhrastructure of spruce kraft pulps studied By atomic force microscopy (AFM) and X -ray photoelectron spectroscopy (XPS) 显示文摘 | Gustafsson J Ciovica L Pehonen J | 2003 | Polymer2003，44，： | 1 |
| 18 | Charge interactions in semi-concentrated titania suspensions at very high ionic strengths显示文摘 | Kosmulski M Durand-Vidal S Gustafsson J | 1999 | Colloids and Surfaces A:Physicochemical and Engineering Aspects1999，157，123： | 1 |
| 19 | Notch signaling mediates hypoxia-induced tumor cell migration and invasion显示文摘 | Sahlgren C Gustafsson MV Jin S | 2008 | Proc Natl Acad Sci USA2008，105，17： | 1 |
| 20 | Fatty acids in control of gene expression显示文摘 | Gustafsson JA | 1998 | Nutr Rev1998，56，： | 1 |
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