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| 1 | The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury显示文摘称为 autophagy 品质上的一个生理的序列由移开蛋白质总数和损坏细胞质的成分决定细胞的生存能力,并且显著地作出贡献到心肌的 ischemia-reperfusion (I/R ) 的度损害。这紧安排的分解代谢的细胞的 ‘ housekeeping’过程向房间提供精力的新来源适应紧张的条件。当支持幸存的机制,而是增加的证据建议它能也导致房间的遗赠,这个过程首先被描述。Autophagy 包括心肌的 I/R 损害在多重心脏的条件的致病被含有。然而,争论至于 autophagy 是否充当保护的机制或在心贡献 I/R 损害的有害效果坚持。这争吵可以在试验性的模型和种包括可变性源自几个因素,并且方法论过去常估计 autophagy。这评论在向操作 autophagy 显著地在压力大多数的条件下面增加心脏的 myocytes 的幸存受到 I/R,和成长兴趣的孤立的心脏的房间在 autophagy 的调整和角色上提供更新的知识是 I/R 损害。这的不安 evolutionarily 保存了细胞内部的清洁的 autophagy 机制,由指向的调整通过在其它之中, rapamycin ( mTOR )的哺乳动物的目标禁止者,腺苷 激活monophosphate 的蛋白质 kinase ( AMPK )调节的人,钙降低代理人, resveratrol , longevinex , sirtuin 使活跃之物, proapoptotic 基因 Bnip3 , IP3 和 lysosome 禁止者,可以对 I/R 授与抵抗到心房间导致的房间死亡。因此,在质问心肌层的 autophagy 的治疗学的操作可以有益于梗塞以后的心脏的愈合并且改变。 | Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat Narula Tiziano M. Scarabelli Richard Knight | 2014 | Journal of Geriatric Cardiology2014，11，4： | 37 |
| 2 | Magnetic nanoparticles for environmental and biomedical applications: A review显示文摘 | Leena Mohammed Hassan G.Gomaa Doaa Ragab Jesse Zhu | 2017 | Particuology2017，15，1： | 16 |
| 3 | Family and twin studies in inflammatory bowel disease显示文摘在不同家庭组以内检验煽动性的肠疾病(IBD ) 的继承的研究是在 IBD 的遗传的最近的分子的进展的基础。在 Crohn 的疾病(CD ) 的导出的可遗传性比在许多另外的复杂疾病高。IBD 的风险在受不了 ulcerative (UC ) 的一个职业人员乐队的一个 CD 职业人员乐队,而是一度的亲戚的一度的亲戚是最高的,更远的亲戚也在增加的风险。在 IBD 的疾病词语索引率在复合家庭并且在三大欧洲成双的研究被检验了。 | Leena Halme Paulina Paavola-Sakki Ulla Turunen Maarit Lappalainen Martti Frkkil Kimmo Kontula | 2006 | World Journal of Gastroenterology2006，12，23： | 8 |
| 4 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 5 | Innate and adaptive immune responses against picornaviruses and their counteractions: An overview显示文摘Picornaviruses, small positive-stranded RNA viruses, cause a wide range of diseases which is based on their differential tissue and cell type tropisms. This diversity is reflected by the immune responses, both innate and adaptive, induced after infection, and the subsequent interactions of the viruses with the immune system. The defense mechanisms of the host and the countermeasures of the virus significantly contribute to the pathogenesis of the infections. Important human pathogens are poliovirus, coxsackievirus, human rhinovirus and hepatitis A virus. These viruses are the beststudied members of the family, and in this review we want to present the major aspects of the reciprocal effects between the immune system and these viruses. | Andreas Dotzauer Leena Kraemer | 2012 | World Journal of Virology2012，1，3： | 6 |
| 6 | Diabetes:特殊免疫细胞亚群或促进1型糖尿病发展显示文摘发表在国际杂志Diabetes上的一项最新研究中,来自东芬兰大学的研究人员通过研究发现,最近描述的一种T细胞亚群或许在1型糖尿病的发生上扮演着关键性的中枢角色;这种名为滤泡T辅助细胞的T细胞亚群在1型糖尿病开始阶段时水平处于增加之中,而且这种现象和疾病相关的常见自身抗体的存在直接相关。 | Tyyne Viisanen Emmi-Leena Ihantola Kirsti Näntö-Salonen Heikki Hyöty Noora Nurminen Jenni Selvenius Auni Juutilainen Leena Moilanen Jussi Pihlajamäki Riitta Veijola Jorma Toppari Mikael Knip Jorma Ilonen Tuure Kinnunen | 2017 | 现代生物医学进展2017，17，4： | 5 |
| 7 | Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India显示文摘AIM:To investigate whether routinely measured clinical variables could aid in differentiating intestinal tuberculosis(ITB)from Crohn’s disease(CD).METHODS:ITB and CD patients were prospectively included at four South Indian medical centres from October 2009 to July 2012.Routine investigations included case history,physical examination,blood biochemistry,ileocolonoscopy and histopathological examination of biopsies.Patients were followed-up after 2 and 6 mo of treatment.The diagnosis of ITB or CD was re-evaluated after 2 mo of antituberculous chemotherapy or immune suppressive therapy respectively,based on improvement in signs,symptoms and laboratory variables.This study was considered to be an exploratory analysis.Clinical,endoscopic and histopathological features recorded at the time of inclusion were subject to univariate analyses.Disease variables with sufficient number of recordings and P<0.05 were entered into logistic regression models,adjusted for known confounders.Finally,we calculated the odds ratios with respective confidence intervals for variables associated with either ITB or CD.RESULTS:This study included 38 ITB and 37 CD patients.Overall,ITB patients had the lowest body mass index(19.6 vs 22.7,P=0.01)and more commonly reported weight loss(73%vs 38%,P<0.01),watery diarrhoea(64%vs 33%,P=0.01)and rural domicile(58%vs 35%,P<0.05).Endoscopy typically showed mucosal nodularity(17/31 vs 2/37,P<0.01)and histopathology more frequently showed granulomas(10/30vs 2/35,P<0.01).The CD patients more frequently reported malaise(87%vs 64%,P=0.03),nausea(84%vs 56%,P=0.01),pain in the right lower abdominal quadrant on examination(90%vs 54%,P<0.01)and urban domicile(65%vs 42%,P<0.05).In CD,endoscopy typically showed involvement of multiple intestinal segments(27/37 vs 9/31,P<0.01).Using logistic regression analysis we found weight loss and nodularity of the mucosa were independently associated with ITB,with adjusted odds ratios of 8.6(95%CI:2.1-35.6)and 18.9(95%CI:3.5-102.8)respectively.Right lower abdominal quadrant pain on examination and involvement of≥3 intestinal segments were independently associated with CD with adjusted odds ratios of 10.1(95%CI:2.0-51.3)and 5.9(95%CI:1.7-20.6),respectively.CONCLUSION:Weight loss and mucosal nodularity were associated with ITB.Abdominal pain and excessive intestinal involvement were associated with CD.ITB and CD were equally common. | Geir Larsson Thrivikrama Shenoy Ramalingom Ramasubramanian Leena Kondarappassery Balakumaran Milada Cvancarova Smstuen Gunnar Aksel Bjune Bjφrn Allan Moum | 2014 | World Journal of Gastroenterology2014，20，17： | 5 |
| 8 | The chemosensory appendage proteome of Amblyomma americanum (Acari: Ixodidae) reveals putative odorant-binding and other chemoreception-related proteins显示文摘Proteomic 分析在孤独的星的 2 个化学感应的附器上被做滴答响, Amblyomma americanum。蛋白质在在先 tarsi,包含嗅觉的 Hallers 机关,并且在触官,包括味觉的 sensilla,与在第三 tarsi 的蛋白质相比。另外,男性和女性滴答响被比较。蛋白质被顺序类似,并且由 3-dimensional 相同建模识别到已知的蛋白质。Proteomic 数据也与从 tick Rhipicephalus microplus 的器官特定的 transcriptomes 相比。在先 tarsi 快车没在第三 tarsi 或触官发现的 lipocalin。在先, tarsi 和触官富有地表示 2 蛋白质,它类似于昆虫有气味的东西绑定蛋白质(OBP ) 。与昆虫 OBP 相比, tick 象 OBP 一样序列缺乏半胱氨酸在 C 减 OBP 不在,并且 1 滴答响象 OBP 一样顺序有类似于 C 加 OBP 的另外的半胱氨酸。类似于抗菌素蛋白质 microplusin 的四蛋白质被发现:2 只表示了在在先 tarsi 并且 1 只在触官表示了。这些蛋白质缺乏 microplusin 铜绑定地点,而是他们被建模有一个重要的内部洞,潜在地一个 ligand 有约束力的地点。类似于 7 被发现差别的灰尘螨变应原 Der p7 和 Der f 的蛋白质在先在女性表示了 tarsi。只表示在的蛋白质在先, tarsi 有类似到否决权,它被知道涉及 ionotropic glutamate 受体聚类。这些结果组成象 OBP 一样蛋白质序列的第一份报告在滴答响并且点到几条研究大街在上滴答响化学感应的接收。 | Robert Renthal Leena Manghnani Sandra Bernal Yanyan Qu Wendell P. Griffith Kim Lohmeyer Felix O. Guerrero Ligia M.F. Borges Adalberto Perez de Leon | 2017 | Insect Science2017，24，5： | 4 |
| 9 | Management of difficult bile duct cannulation in ERCP显示文摘In Encoscopic Retrograde Cholangiopancreatography(ERCP),the main concern is to gain access into the bile duct while avoiding the pancreatic duct because of the risk of post-ERCP pancreatitis.Diffi cult cannulation is defined as a situation where the endoscopist,using his/her regularly used cannulation technique,fails within a certain time limit or after a certain number of unsuccessful attempts.Different methods have been developed to manage diffi cult cannulation.The most common solution is to perform a precut papillotomy either with a needle knife or with a sphincterotome with or without a guide wire.This review describes different methods to overcome cases of difficult cannulation.We will discuss the success rate and complication rates associated with different methods of reaching the biliary tract. | Marianne Udd Leena Kylnp Jorma Halttunen | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 4 |
| 10 | Mortality in ulcerative colitis and Crohn’s disease. A population-based study in Finland显示文摘 | Pia Manninen Anna-Liisa Karvonen Heini Huhtala Martin Rasmussen Maarit Salo Leena Mustaniemi Ismo Pirttiniemi Pekka Collin | 2011 | Journal of Crohn’s and Colitis2011，，5： | 3 |
| 11 | Influence of emergent macrophyte (Phragmites australis) density on water turbulence and erosion of organic-rich sediment显示文摘The effects of the emergent macrophyte Phragmites australis on water turbulence, bottom shear velocity and water turbidity were experimentally studied with the stem densities 0 stems/m 2 -100 stems/m 2 and using organic-rich sediment. It is found that the maximum root-mean-square (rms) velocity and shear velocity decrease linearly with increasing stem density. By affecting the height of peak turbulence values, emergent plants can thus lower the frequency of sediment erosion events. Additionally, the slope of the rms turbulence increment decreases with increasing stem density. Thus, also the duration of strong turbulence is affected by the density of emergent macrophytes. The critical shear velocity for sediment resuspension is 0.0035 m/s-0.0055 m/s and not affected by the stem density. In the absence of macrophytes, water flow causes a 6.3-fold increment in turbidity, but with macrophytes turbidity values remain lower. The experiments suggest that even relatively low densities of Phragmites can have substantial effects on water turbulence and consequently on water quality. | HORPPILA Jukka KAITARANTA Joni JOENSUU Laura NURMINEN Leena | 2013 | Journal of Hydrodynamics2013，25，2： | 3 |
| 12 | Sleeve gastrectomy and the risk of leak: a systematic analysis of 4,888 patients显示文摘 | Alexander Aurora Leena Khaitan Alan Saber | 2012 | Surgical Endoscopy2012，，6： | 2 |
| 13 | The Clinical Course of Acute Pancreatitis and the Inflammatory Mediators That Drive It显示文摘 | Leena Kyl?np?? Zoltán Rakonczay Derek A. O’Reilly David A. Hart | 2012 | International Journal of Inflammation2012，，： | 2 |
| 14 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 15 | Toxic megacolon associated Clostridium difficile colitis显示文摘Toxic megacolon is a severe complication of Clostridium difficile (C.difficile) colitis.As the prevalence of C. difficile colitis increases and treatments become more refractory, clinicians will encounter more patients with C. difficile associated toxic megacolon in the future. Here, we review a case of toxic megacolon secondary to C. difficile colitis and review the current literature on diagnosis and management. We identify both clinical and radiologic criteria for diagnosis and discuss both medical and surgical options for management. Ultimately, we recommend using the Jalen criteria in conjunction with daily abdominal radiographs to help establish the diagnosis of toxic megacolon and to make appropriate treatment recommendations. Aggressive medical management using supportive measures and antibiotics should remain the mainstay of treatment. Surgical intervention should be considered if the patient does not clinically improve within 2-3 d of initial treatment. | Leena Sayedy Darshan Kothari Robert J Richards | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，8： | 2 |
| 16 | Advancements in high refractive index media:from quantum coherence in atomic systems to deep subwavelength coupling in metamaterials[Invited]显示文摘Refractive index enhancement is crucial in the fields of lithography,imaging,optical communications,solar devices,and many more.We present a review of advancements in the process of designing high refractive index metamaterials,starting from quantum coupling and photonic bandgap materials to metamaterials utilizing deep subwavelength coupling to achieve ever-high values of refractive index.A particular attention is given to experimentally verified schemes in engineering a high index of refraction.The understanding of the evolution of material design from intrinsic electronic states manipulation to meta-atoms design is not only fascinating but also a prerequisite to developing successful devices and applications. | Leena Singh 张伟力 | 2020 | Chinese Optics Letters2020，18，6： | 2 |
| 17 | Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents显示文摘 | Pauliina Molander Clas‐G?ran af Bj?rkesten Harri Mustonen Johanna Haapam?ki Matti Vauhkonen Kaija‐Leena Kolho Martti F?rkkil? Taina Sipponen | 2012 | Inflamm Bowel Dis2012，，11： | 2 |
| 18 | Prognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy显示文摘 | Rory O’Hanlon Agata Grasso Michael Roughton James C. Moon Susan Clark Ricardo Wage Jessica Webb Meghana Kulkarni Dana Dawson Leena Sulaibeekh Badri Chandrasekaran Chiara Bucciarelli-Ducci Ferdinando Pasquale Martin R. Cowie William J. McKenna Mary N. Shep | 2010 | Journal of the American College of Cardiology2010，，11： | 2 |
| 19 | 12-钨磷酸在AlSBA-15上的固定化及其乙酰化催化活性(英文)显示文摘12-Tungstophosphoric heteropoly acid(TPA) with a Keggin structure was introduced into Al-incorporated mesoporous molecular sieves(AlSBA-15) by the incipient wetness method.The materials were characterized by X-ray diffraction,nitrogen adsorption,scanning electron microscopy,UV-Vis diffuse reflectance and Raman spectroscopy,which confirmed the Keggin and mesopore structure.Its catalytic activity was evaluated under solvent-free conditions in the liquid phase at 333-383 K for the propionylation of anisole with propionic anhydride.The catalysts used were AlSBA-15,10%,20%,and 40% TPA/AlSBA-15,and 20% TPA/MCM-48.In the propionylation of anisole with propionic anhydride,the substitution occurred predominantly at the para position.The 20% TPA/AlSBA-15 catalyst gave a total product yield of 48% with 98% selectivity towards 4-methoxypropiophenone.The regenerability of the catalyst was also studied and was found to be excellent. | S.REVATHI M.Esther Leena PREETHI D.MANIKANDAN D.DIVAKAR A.Valentine RUPA T.SIVAKUMAR | 2008 | 催化学报2008，29，12： | 2 |
| 20 | Application of a littoral Baltic Sea resuspension model in a eutrophic lake-factors behind differences in the model performance显示文摘The performance of a linear resuspension model developed in the Baltic Sea was studied in the conditions of a eutrophic Lake Kirkkoj(a|¨)rvi(southern Finland).The model predicts sediment resuspension rate using data on vegetation cover,wind and sediment quality as an input.When the original model coefficients were used,the model resulted on average 1.8 fold overestimation of the resuspension rate in Kirkkoj(a|¨)rvi.This was due to lower fetch and water depth,and less consolidated sediment of Kirkkoj(a|¨)rvi compared with the Baltic Sea study site.When coefficients were adjusted for Kirkkoj(a|¨)rvi,the model predictions were 1.1 times the measured values.Due to the continuous resuspension,the effect of the wind term in the model was so low that it could be excluded without affecting the accuracy of model predictions.The study demonstrated that in a shallow eutrophic lake accurate predictions on resuspension rate can be made using only data on sediment quality and on factors inhibiting resuspension(macrophytes).The model residuals increased with increasing resuspension rate and high rates of resuspension were underestimated by the model.Due to the fluffy sediment in Kirkkoj(a|¨)rvi,erosion of sediment increases more than linear with increasing shear stress.Thus in such conditions,even better predictions could be achieved by a non-linear resuspension model. | Jukka Horppila Joni Kaitaranta Leena Nurminen | 2015 | International Journal of Sediment Research2015，30，2： | 2 |
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