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| 1 | 瑞舒伐他汀对存在亚临床动脉粥样硬化的低危人群颈动脉内膜中层厚度进展的影响——METEOR试验显示文摘背景:动脉粥样硬化往往在机体出现症状之前就已有所进展。目前,我们尚不清楚Framingham风险评分(Framinghaln risk score,FRS)较低的轻中度亚临床动脉粥样硬化中年人群是否能从治疗中获益。
目的:评价为期2年的他汀类药物治疗能否减缓颈动脉内膜中层厚度(carotid intimamedia thickness,CIMT)继续增厚或使粥样斑块消退。
设计、地点及参试者:“瑞舒伐他汀对内膜中层厚度影响的测评研究(Measuring Effects on Intima-Media Thickness:an Evaluation of Rosuvastatin,METEOR)”是2002年8月至2006年5月在美国及欧洲61个基层医疗中心开展的一项随机、双盲、安慰剂对照研究,共纳入984名参试者,有的参试者仅以年龄(平均年龄,57岁)为冠心病的危险因素,有的参试者10年内FRS低于10%、CIMT重庞增厚(1.2~3.5mm)、LDL胆固醇水平有所升高(平均值,154mg/dL)。
干预:参试者服用40mg瑞舒伐他汀或安慰剂。
主要观测指标:12个颈动脉位点最大CIMT的变化率(经B超检测);颈总动脉位点、颈动脉窦位点及颈内动脉位点最大CIMT的变化,颈总动脉位点平均CIMT的变化。仅在瑞舒伐他汀组中评估CIMT的消退情况。
结果:瑞舒伐他汀组参试者LDL胆固醇平均(SD)水平由基线时的155(24.1)mg/dL降至78(27.5)mg/dL,平均降低49%(与安慰剂组相比P〈0.001)。瑞舒伐他汀组12个颈动脉位点最大CIMT的变化值为-0.0014(95%CI,-0.0041~0.0014)mm/y,安慰剂组12个颈动脉位点最大CIMT的变化值为Q0131(95%CI,Q0087~Q0174)mm/y(P〈0.001)。瑞舒伐他汀组颈总动脉位点最大CIMT的变化值为-0.0038(95%CI,-0.0064~-0.0013)mm/y(P〈0.001),颈动脉窦位点最大CIMT的变化值为-0.0040(95%CI,-0.0090~0.0010)mm/y(P〈0.001),颈内动脉位点最大CIMT的变化值为0.0039(95%CI,-0.0009~0.0088)mm/y(P=0.02)。瑞舒伐他汀组颈总动脉位点平均CIMT的变化值为0.0004(95%CI,-0.0011~0.0019)mm/y(P〈0.001)。P值均为与安慰剂组相比。总的来说,瑞舒伐他汀具有良好的耐受性,很少引发严重的心血管不良事件(在2年内有6名参试者[0.86%]出现8起不良事件[1.1%])。
结论:对于FRS低于10%的亚临床动脉粥样硬化中年人群而言,瑞舒伐他汀能够在2年内显著降低最大CIMT的进展速率,与安慰剂相比差异具有统计学显著性。但是,瑞舒伐他汀无法诱导病变消退。今后,我们仍需开展大型远期试验来明确上述研究结果的临床意义. | John R. Crouse Ⅲ Joel S. Raichlen Ward A. Riley Gregory W. Evans Mike K. Palmer Daniel H. O' Leary Diederick E. Grobbee Michiel L. Bots 李军(译) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 44 |
| 2 | The PI3K/Akt/m TOR pathway in ovarian cancer: therapeutic opportunities and challenges显示文摘The phosphatidylinositol 3 kinase(PI3K) pathway is frequently altered in cancer, including ovarian cancer(OC). Unfortunately, despite a sound biological rationale and encouraging activity in preclinical models, trials of first-generation inhibitors of mammalian target of rapamycin(m TOR) in OC have demonstrated negative results. The lack of patient selection as well as resistance to selective m TOR complex-1(m TORC1) inhibitors could explain the disappointing results thus far. Nonetheless, a number of novel agents are being investigated, including dual m TORC1/m TORC2, Akt, and PI3 K inhibitors. Although it is likely that inhibition of the PI3K/Akt/m TOR pathway may have little effect in unselected OC patients, certain histological types, such as clear cell or endometrioid OC with frequent phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha(PIK3CA) and/or phosphatase and tensin homolog(PTEN) alterations, may be particularly suited to this approach. Given the complexity and redundancy of the PI3 K signaling network, PI3 K pathway inhibition may be most useful in combination with either chemotherapy or other targeted therapies, such as MEK inhibitors, anti-angiogenic therapy, and hormonal therapy, in appropriately selected OC patients. Here, we discuss the relevance of the PI3 K pathway in OC and provide an up-to-date review of clinical trials of novel PI3 K inhibitors alone or in combination with cytotoxics and novel therapies in OC. In addition, the challenges of drug resistance and predictive biomarkers are addressed. | Bianca Cheaib Aurélie Auguste Alexandra Leary | 2015 | Chinese Journal of Cancer2015，34，1： | 27 |
| 3 | 老年人社会支持与期望的调查研究显示文摘运用问卷调查法,通过对272名城市老年人的调查,考察了老年人的社会支持与期望的现状及其特点。结果发现:老年人的社会支持系统很不平衡,性别、年龄、受教育年限和职业对老年人的婚姻和家庭生活,人际关系和互助行为,住房情况和经济状况,以及心理需要和社会期望等具有不同的影响;相当比例的老年人在不同侧面尚需要家人和社会的关注、理解和支持。 | 陈传锋 严建雯 Eleanor O’Leary 贺豪振 | 2006 | 心理科学2006，29，1： | 24 |
| 4 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 5 | 应用CT泌尿系成像检出膀胱癌——单个医疗中心的经验显示文摘目的评估CT泌尿系成像在高危病人中检出膀胱癌的性能特点。方法本研究为回顾性、HIPPA依从试验,经学术审查委员会批准。 | C.A.Sadow S.G.Silverman M.P.O’Leary J.E.Signorovitch 林满霞 | 2008 | 国际医学放射学杂志2008，31，A06： | 6 |
| 6 | The association of layperson characteristics with the quality of simulated cardiopulmonary resuscitation performance显示文摘BACKGROUND: Few studies have examined the association of layperson characteristics with cardiopulmonary resuscitation(CPR) provision. Previous studies suggested provider characteristics, including age and gender, were associated with CPR quality, particularly chest compression(CC) depth. We sought to determine the association of subject characteristics, including age and gender with layperson CPR quality during an unannounced simulated CPR event. We hypothesized shallower CC depth in females, and older-aged subjects.METHODS: As part of a larger multicenter randomized controlled trial of CPR training for cardiac patients' caregivers, CPR skills were assessed 6 months after training. We analyzed associations between subject characteristics and CC rate, CC depth and no-? ow time. Each variable was analyzed independently; signi? cant predictors determined via univariate analysis were assessed in a multivariate regression model.RESULTS: A total of 521 laypersons completed a 6-month CPR skills assessment and were included in the analysis. Mean age was 51.8±13.7 years, 75% were female, 57% were Caucasian. Overall, mean CC rate was 88.5±25.0 per minute, CC depth was 50.9±2.0 mm, and mean no-flow time was 15.9±2.7 sec/min. CC depth decreased signi? cantly in subjects >62 years(P<0.001). Male subjects performed deeper CCs than female subjects(47.5±1.7 vs. 41.9±0.6, P<0.001).CONCLUSION: We found that layperson age >62 years and female gender are associated with shallower CC depth. | Marion Leary David G.BucMer Daniel J.Ikeda Daiane A.Saraiva Robert A.Berg Vinay M.Nadkarni Audrey L.Blewer Benjamin S.Abella | 2017 | World Journal of Emergency Medicine2017，8，1： | 5 |
| 7 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 8 | 爱尔兰海洋经济和资源显示文摘什么是爱尔兰?
这或许是个奇怪的问题。目前还很少有人认为爱尔兰是一个海洋国家。如果有人认为爱尔兰由9万平方公里的陆域面积和90万平方公里的海域面积组成,就更加稀奇了。 | Y Shields J O’Cornor J O’Leary 周怡圃 王占坤 羊志洪 | 2010 | 经济资料译丛2010，，1： | 4 |
| 9 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 10 | Additive manufacturing in radiation oncology:a review of clinical practice,emerging trends and research opportunities显示文摘The additive manufacturing(AM)process plays an important role in enabling cross-disciplinary research in engineering and personalised medicine.Commercially available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes,often leading to non-conformal geometries,time-consuming manufacturing process and high costs.An emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation therapy.In this review,we:•highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture•explore common clinical workflows involving radiotherapy tools such as bolus,compensators,anthropomorphic phantoms,immobilisers,and brachytherapy moulds;and•investigate how current AM processes are exploited by researchers to achieve patient tissuelike imaging and dose attenuations.Finally,significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications. | Rance Tino Martin Leary Adam Yeo Elizabeth Kyriakou Tomas Kron Milan Brandt | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 3 |
| 11 | A review of shape memory alloy research, applications and opportunities显示文摘 | Jaronie Mohd JaElsevier LtdElsevier Ltdni Martin Leary Aleksandar Subic Mark A. Gibson | 2013 | Materials and Design2013，，： | 3 |
| 12 | Increased β-Cyanoalanine Nitrilase Activity Improves Cyanide Tolerance and Assimilation in Arabidopsis显示文摘植物自然地生产被快速的吸收的一个过程在他们的房间在底层维持的氰化物(CN ) 。然而,与象工业污染那样的活动联系的环境 CN 的高集中对植物有毒。因此对作为一条潜在的线路增加植物的 CN detoxification 能力到植物救治有兴趣。这里, Pseudomonas fluorescens -cyanoalanine nitrilase pinA 与相比的 Arabidopsis 幼苗 overexpressing 野类型并且为生长的一根 -cyanoalanine nitrilase 大美人线(Atnit4 ) 面对外长的 CN。在有 CN 的孵化以后, +PfpinA 幼苗增加了漂白与相比的根长度,增加的新鲜重量,和减少的叶野类型,显示增加了 CN 忍耐。没有 -cyanoalanine synthase 活动的增加,增加的忍耐被完成,在氰化物吸收小径的另外的酶,建议那项 nitrilase 活动是为氰化物 detoxification 的限制因素。用标记实验[13C ] KCN 证明改变的 CN 忍耐能被差别向改变的 -cyanoalanine nitrilase 活动引起的 Asn 从 CN 在流动解释。代谢物在 CN 处理以后介绍提供了新卓见进下游的新陈代谢,揭示由 photorespiratory 氮周期和芳香的氨基酸的累积的 Asn 的向前的新陈代谢。 | Brendan O'Leary GaU M. Preston Lee J. Sweetlove | 2014 | Molecular Plant2014，7，1： | 3 |
| 13 | Telaprevir- and Boceprevir-based Triple Therapy for Hepatitis C in Liver Transplant Recipients With Advanced Recurrent Disease: A Multicenter Study显示文摘 | Elizabeth C. Verna Varun Saxena James R. Burton Jacqueline G. O’Leary Jennifer L. Dodge Richard T. Stravitz Josh Levitsky James F. Trotter Gregory T. Everson Robert S. Brown Norah A. Terrault | 2015 | Transplantation2015，，8： | 2 |
| 14 | The effects of psychological contract breach and organizational cynicism: not all social exchange violations are created equal显示文摘 | Jonathan L.Johnson Anne M.O’Leary‐Kelly | 2003 | J Organiz Behav2003，，5： | 2 |
| 15 | Carbonaceous nanomaterials for the enhancement of TiO 2 photocatalysis显示文摘 | Rowan Leary Aidan Westwood | 2010 | Carbon2010，，3： | 2 |
| 16 | The adaptive significance of amphistomatic leaves 显示文摘 | Mott K A Gibson A G O'Leary J W | 1982 | Plant Cell Environ1982，9，： | 2 |
| 17 | The nature and function of self-esteem: Sociometer theory显示文摘 | Mark R. Leary Roy F. Baumeister | 2000 | Advances in Experimental Social Psychology2000，，： | 2 |
| 18 | Cardiopulmonary Resuscitation Quality: Improving Cardiac Resuscitation Outcomes Both Inside and Outside the Hospital: A Consensus Statement From the American Heart Association显示文摘 | Peter A. Meaney Bentley J. Bobrow Mary E. Mancini Jim Christenson Allan R. de Caen Farhan Bhanji Benjamin S. Abella Monica E. Kleinman Dana P. Edelson Robert A. Berg Tom P. Aufderheide Venu Menon Marion Leary | 2013 | Circulation2013，，4： | 2 |
| 19 | Observing the stages of bystander intervention in virtual reality simulation显示文摘BACKGROUND: Understanding bystander reactions to an emergency is an important component of effective training. Four stages of bystander intervention (BI) have been previously described: noticing the situation as a problem, interpreting when it is appropriate to intervene, recognizing personal responsibility to intervene, and knowing how to intervene. Using virtual reality (VR) to simulate emergencies such as sudden cardiac arrest (SCA) can be used to study these stages. METHODS: In a secondary analysis of an observational cohort study, we analyzed bystander self-effi cacy for stages of BI before and after simulated SCA. Each subject participated in a singleplayer, immersive, VR SCA scenario. Subjects interacted with simulated bystanders through voice commands (“call 911”,“get an AED”). Actions taken in scenario, like performing CPR, were documented. Scenario BI actions were compared based on dichotomized comfort/discomfort. RESULTS: From June 2016 to June 2017, 119 subjects participated. Average age was 37±14 years, 44% were female and 46% reported CPR training within 2 years. During the scenario, 98%“noticed the event” and “interpreted it as a problem”, 78%“took responsibility”, and 54%“possessed the necessary skills”. Self-effi cacy increased from pre- to post-scenario: noticing the event increased from 80% to 96%;interpreting as a problem increased from 86% to 97%;taking responsibility increased from 56% to 93%;possessing necessary skills increased from 47% to 63%(P<0.001). CONCLUSION: Self-efficacy to respond to an SCA event increased pre- to post-scenario. Bystanders who reported feeling comfortable “taking responsibility to intervene” during an emergency were more likely to take action during a simulated emergency. | David G. Buckler Alfredo Almodovar Jr Paul Snobelen Benjamin S. Abella Audrey Blewer Marion Leary | 2019 | World Journal of Emergency Medicine2019，10，3： | 2 |
| 20 | An evaluation of post length within the elastic limits of dentin显示文摘 | Leary JM Aquilino SA Svare CW | 1987 | J Prosthet Dent1987，57，3： | 2 |
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