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| 1 | The compelling link between physical activity and the body's defense system显示文摘This review summarizes research discoveries within 4 areas of exercise immunology that have received the most attention from investigators :(1) acute and chronic effects of exercise on the immune system,(2) clinical benefits of the exercise—immune relationship,(3) nutritional influen?ces on the immune response to exercise, and(4) the effect of exercise on immunosenescence. These scientific discoveries can be organized into distinctive time periods: 1900-1979, which focused on exercise-induced changes in basic immune cell counts and function; 1980-1989, during which seminal papers were published with evidence that heavy exertion was associated with transient immune dysfunction, elevated inflammatory biomarkers,and increased risk of upper respiratory tract infections; 1990-2009, when additional focus areas were added to the field of exercise immunology including the interactive effect of nutrition, effects on the aging immune system, and inflammatory cytokines; and 2010 to the present, when technological advances in mass spectrometry allowed system biology approaches(i.e., metabolomics, proteomics, lipidomics, and microbiome characterization) to be applied to exercise immunology studies. The future of exercise irmmunology will take advantage of these technologies to provide new insights on the interactions between exercise, nutrition, and immune function, with application down to the person?alized level. Additionally, these methodologies will improve mechanistic understanding of how exercise-induced immune perturbations reduce the risk of common chronic diseases. | David C.Nieman Laurel M.Wentz | 2019 | Journal of Sport and Health Science2019，8，3： | 32 |
| 2 | Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature显示文摘The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended. | Natasha A Koloski Laurel Bret Graham Radford-Smith | 2008 | World Journal of Gastroenterology2008，14，2： | 16 |
| 3 | Dermal fibroblast expression of stromal cellderived factor-1 (SDF-1) promotes epidermal keratinocyte proliferation in normal and diseased skin显示文摘Stromal 房间为 overlying 上皮提供关键微型环境。这里,我们调查了 stromal 的表示和功能房间特定的蛋白质, stromal 导出房间的 factor-1 (SDF-1 ) ,在正常人的皮肤并且在 diseased 的纸巾皮肤。Immunohistology 和激光俘获 microdissection (最小公倍数) 联合了揭示的量的即时 RT-PCR 那 SDF-1 组成地并且主要在 vivo 在正常人的皮肤在真皮的 stromal 房间被表示。使我们吃惊的是,一极其, SDF-1 抄写的高水平在 vivo 在正常人的皮肤的真皮被观察,比打字由许多更高的 mRNA 表示水平证实了我骨胶原,在人的皮肤的最丰富、高度表示的蛋白质。SDF-1 也是在包括干癣,基础房间癌(电子消息传输方式) ,和有鳞的房间癌(SCC ) 的许多人的皮混乱的纸巾的 upregulated。为 SDF-1 和 HSP47 (热吃惊蛋白质 47 ) 的两倍 immunostaining,成纤维细胞的一个标记,表明成纤维细胞是在正常和 diseased 皮肤的 stroma-cell-derived SDF-1 的主要来源。机能上地, SDF-1 激活 ERK (extracellular-signal-regulated kinases ) 是的小径和功能刺激表皮的 keratinocyte 增长的 mitogen。在有到皮肤等价物文化的 rhSDF-1 的真皮的成纤维细胞和处理的 SDF-1 的两 overexpression 显著地增加了 keratinocyte 层和表皮的厚度的数字。相反地, keratinocyte 增长上的 SDF-1 的刺激功能被防碍 CXCR4 将近完全消除, SDF-1 的特定的受体,或由在成纤维细胞的 SDF-1 击倒。我们的数据揭示那 SDF-1 极其高级处于生理、病理学的皮肤条件为表皮的 keratinocyte 增长提供关键微型环境。 | Chunji Quan Moon Kvun Cho Yuan Shao Laurel E. Mianecki Eric Liao Daniel Perry Taihao Quan | 2015 | Protein & Cell2015，6，12： | 8 |
| 4 | History and Progress of the North American Soil Geochemical Landscapes Project,2001-2010显示文摘In 2007,the U.S.Geological Survey,the Geological Survey of Canada,and the Mexican Geological Survey initiated a low-density(1 site per 1600 km2,13323 sites) geochemical and mineralogical survey of North American soils(North American Soil Geochemical Landscapes Project).Sampling and analytical protocols were developed at a series of workshops in 2003-2004 and pilot studies were conducted from 2004-2007.The ideal sampling protocol at each site includes a sample from 0-5 cm depth,a composite of the soil A horizon,and a sample from the soil C horizon.The <2-mm fraction of each sample is analyzed for Al,Ca,Fe,K,Mg,Na,S,Ti,Ag,Ba,Be,Bi,Cd,Ce,Co,Cr,Cs,Cu,Ga,In,La,Li,Mn,Mo,Nb,Ni,P,Pb,Rb,Sb,Sc,Sn,Sr,Te,Th,Tl,U,V,W,Y,and Zn by inductively coupled plasma-mass spectrometry and inductively coupled plasma-atomic emission spectrometry following a near-total digestion in a mixture of HCl,HNO3,HClO4,and HF.Separate methods are used for As,Hg,Se,and total C on this same size fraction.The major mineralogical components are determined by a quantitative X-ray diffraction method.Sampling in the conterminous U.S.was completed in 2010(c.4800 sites) with chemical and mineralogical analysis currently underway.In Mexico,approximately 66% of the sampling(871 sites) had been done by the end of 2010 with completion expected in 2012.After completing sampling in the Maritime provinces and portions of other provinces(472 sites,7.6% of the total),Canada withdrew from the project in 2010.Preliminary results for a swath from the central U.S.to Florida clearly show the effects of soil parent material and climate on the chemical and mineralogical composition of soils.A sample archive will be established and made available for future investigations. | David B.Smith William F.Cannon Laurel G.Woodruff Francisco Moreira Rivera Andrew N.Rencz Robert G.Garrett | 2012 | 地学前缘2012，19，3： | 7 |
| 5 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 6 | 在线学习者特征分析显示文摘 | Patrick J.Fahy Laurel Archer 肖俊洪 | 2000 | 中国远程教育2000，，11： | 5 |
| 7 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 8 | 抗氧化剂L-乙酰半胱氨酸对大鼠脉冲噪声的保护作用显示文摘目的 研究抗氧化剂L 乙酰半胱氨酸是否能够保护脉冲噪声引起的耳聋。方法 第 1组动物 :8只大鼠暴露在16 0dBSPL 5 0次脉冲噪声。第 2组动物 :10只大鼠同样暴露 16 0dBSPL 5 0次脉冲噪声 ,但在噪声暴露前 1h ,噪声暴露后立刻 ,噪声暴露后 3h ,给予L 乙酰半胱氨酸腹腔内注射 (35 0mg·kg-1,IP)。第 3组动物 :5只给予腹腔注射L 乙酰半胱氨酸 3次 ,注射方法与第 2组相同 ,不暴露脉冲噪声。全部动物通过脑干诱发电位检测听力阈值在噪声前 ,噪声后立刻 ,噪声后 1d ,1,2 ,4wk。结果 第 1组 :比较噪声前和噪声后 ,全部频率有明显听力损失。第 2组 :大鼠暴露同样剂量噪声 ,立刻和 1天后检测ABR阈值与暴露前相比听力损失明显 ,1wk后在 4到 2 0kHz都有听力损失 ,但在 31 5和 4 0kHz已不明显。在 2和 4wk之后 ,各频率听力损失不明显。第 3组 :立刻 ,1d后 ,4wk后测量脑干诱发电位各频率无听力损失。结论 抗氧化剂L 乙酰半胱氨酸能够保护脉冲噪声引起的听力损害。 | 邱建新 童步升 吴开乐 Gran Laurell Erik Borg 段茂利 | 2004 | 中国药理学通报2004，20，7： | 3 |
| 9 | Tolerance of nonsteroidal antiinflammatory drugs in patients with inflammatory bowel disease显示文摘 | Gregory F Bonner Michelle Walczak Laurel Kitchen Manuel Bayona | 2000 | The American Journal of Gastroenterology2000，，8： | 2 |
| 10 | 自然种群中的同类相食显示文摘自然界中存在多种捕食行为,人们对于不同种群间的捕食行为的研究较为广泛。然而,同类相食的行为在很多种群也会发生。同类相食是指同物种内个体或小群间的捕食,是很多物种对于环境因素的正常反应,也是一种种群内部的捕食者-猎物之间相互作用。物种本身对环境适应能力的强弱、外环境的多种因素都会对同类相食的行为产生影响。而同类相食存在于许多物种,并且在时空上深刻影响种群的年龄结构和物种丰盛度。在简单的近缘物种组成的群落中也起关键的调节作用,使得简单的食物网变得更为复杂:对同类相食的研究有助于理解物种丰盛度的内部调节机制,也能在一定程度上解释物种间的生态位重叠。 | 黄大明 张天曦 李淑芬 Laurel R.Fox | 2019 | 中国科技纵横2019，0，7： | 2 |
| 11 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 12 | A morphometric study of the structures bordering the infra-cochlear corridor-Relevant for endoscopic/microscopic ear surgery显示文摘Application of surgical endoscope, used alone or in combination with the surgical microscope, for the operative management of ear and temporal bone conditions may allow improved access and clearance of disease. Preservation of normal structures may also be improved.As the use of this tool is increasing, the need for better understanding of the anatomy of the ear is becoming evident. This is particularly so for endoscopic surgery aiming at removal of lesions involving the infra-cochlear corridor and/or petrous apex.Human temporal bone-derived labyrinth casts(molds), originally made for endolymphatic duct and sac analysis which genuinely represent the membranous labyrinth and its adjacent soft tissues, were morphometrically analyzed in terms of the anatomic relations between structures in and around the infra-cochlear corridor. The distance between the petrous carotid artery(PCA) and the basal turn of the cochlea, the distance between PCA and infra-cochlear vein(ICV)/cochlear aqueduct(CA), and the distance between the lower surface of basal cochlear turn and the point where the carotid artery and jugular vein(JV) meet close to the jugular foramen, were measured to be around 1.3 mm, 6 mm and 8 mm respectively, thus constituting an approximate 6?8 mm2 infra-cochlear corridor. This analysis and further study with larger samples might be helpful for operation via this corridor led to the petrous apex where cholesterol granuloma, cholesteatoma and other lesions are not uncommon. | Wei Liu Yongtian Lu Goran Laurell Vincent Cousins | 2018 | Journal of Otology2018，13，3： | 2 |
| 13 | GABA B Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K + Channels显示文摘 | Pan-Yue Deng Zhaoyang Xiao Chuanxiu Yang Lalida Rojanathammanee Laurel Grisanti John Watt Jonathan D. Geiger Rugao Liu James E. Porter Saobo Lei | 2009 | Neuron2009，，2： | 2 |
| 14 | The role of endoscopy in the management of obscure GI bleeding显示文摘 | Laurel Fisher Mary Lee Krinsky Michelle A. Anderson Vasundhara Appalaneni Subhas Banerjee Tamir Ben-Menachem Brooks D. Cash G. Anton Decker Robert D. Fanelli Cindy Friis Norio Fukami M. Edwyn Harrison Steven O. Ikenberry Rajeev Jain Terry Jue Khalid Khan | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 15 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 16 | 色彩管理与彩色印刷技术的发展显示文摘色彩管理的发展,极大地推动了彩色数字印刷技术的普及。作者对这几万面进行了阐述,并对Ipex 2002上即将展出的这方面技术进行了介绍。 | Laurel Brunner 张鸣 | 2001 | 今日印刷2001，，6： | 2 |
| 17 | Evolutionary ecology of chemosensation and its role in sensory drive显示文摘 | Laurel R. YOHE Philipp BRAND | 2018 | Current Zoology2018，64，4： | 2 |
| 18 | Adverse events of upper GI endoscopy显示文摘 | Tamir Ben-Menachem G. Anton Decker Dayna S. Early Jerry Evans Robert D. Fanelli Deborah A. Fisher Laurel Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Rajeev Jain Terry L. Jue Khalid M. Khan Mary L. Krinsky Phyllis M. Malpas John T. Maple Ravi N. S | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 19 | The Spatial Clustering of Science and Capital: Accounting for Biotech Firm-Venture Capital Relationships显示文摘 | Walter W. Powell Kenneth W. Koput James I. Bowie Laurel Smith-Doerr | 2002 | Regional Studies2002，，3： | 2 |
| 20 | The role of endoscopy in the evaluation of suspected choledocholithiasis显示文摘 | John T. Maple Tamir Ben-Menachem Michelle A. Anderson Vasundhara Appalaneni Subhas Banerjee Brooks D. Cash Laurel Fisher M. Edwyn Harrison Robert D. Fanelli Norio Fukami Steven O. Ikenberry Rajeev Jain Khalid Khan Mary Lee Krinsky Laura Strohmeyer Jason A | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
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