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| 1 | 金属板材激光弯曲成形规律的研究显示文摘用大变形弹塑性有限元法对金属板材柔性成形新工艺——激光弯曲进行了动态数值模拟。论证了板料的几何参数和工艺参数与变形的相互关系。模拟结果与试验吻合较好。 | 李纬民 Manfred Geiger Frank Vollertsen | 1998 | 中国激光1998,25,9: | 38 |
| 2 | Plant Sucrose Transporters from a Biophysical Point of View显示文摘更高的植物使用蔗糖的多数作为他们的主要活动糖类。质子驱动的蔗糖 transporters 玩在 cell-to-cell 和在整个植物的蔗糖的长途的分发的一个关键角色。一个很否定的植物膜潜力和蔗糖 transporters 到的能力积累超过 1 的蔗糖集中 ? M 显示植物与唯一的结构、功能的特征发展了 transporters。然而,运输机制和这些 nano 机器的结构 / 功能的领域的知识是仍然碎片的。在这评论,植物蔗糖 transporters 的生物物理的性质的当前的知识被总结并且讨论。 | Dietmar Geiger | 2011 | Molecular Plant2011,4,3: | 17 |
| 3 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004,2,1: | 13 |
| 4 | 现代发动机润滑系统的开发显示文摘现代轿车发动机的额定转速设计得越来越高,有更多的内部零件(多气门发动机)需要润滑。介绍了按照各耗油部位由最重要影响参数决定的实际需油量减少实际供油量的研究开发结果。在这些成果的基础上,提出了将CAE辅助工具与实际试验数据相结合的优化策略。结论中的建议提出了实际润滑系统和通风系统设计以及降低功率消耗和润滑油消耗的优化潜力。 | Koch F Maassen F Geiger U 吴鹏 | 1999 | 国外内燃机1999,31,1: | 9 |
| 5 | Multiple Calcium-Dependent Kinases Modulate ABA-Activated Guard Cell Anion Channels显示文摘 | Sonke Scherzer Tobias Maierhofer Khaled A.S. Al-Rasheid Dietmar Geiger Rainer Hedrich | 2012 | Molecular Plant2012,5,6: | 7 |
| 6 | The fungal UmSrt1 and maize ZmSUT1 sucrose transporters battle for plant sugar resources显示文摘The biotrophic fungus Ustilago maydis causes corn smut disease, inducing tumor formation in its host Zea mays. Upon infection, the fungal hyphae invaginate the plasma membrane of infected maize cells, establishing an interface where pathogen and host are separated only by their plasma membranes. At this interface the fungal and maize sucrose transporters, UmSrt1 and ZmSUT1, compete for extracellular sucrose in the corn smut/maize pathosystem. Here we biophysically characterized ZmSUT1 and UmSrt1 in Xenopus oocytes with respect to their voltage-,pH-and substrate-dependence and determined affinities toward protons and sucrose. In contrast to ZmSUT1,UmSrt1 has a high affinity for sucrose and is relatively pH-and voltage-independent. Using these quantitative parameters, we developed a mathematical model to simulate the competition for extracellular sucrose at the contact zone between the fungus and the host plant. This approach revealed that UmSrt1 exploits the apoplastic sucrose resource, which forces the plant transporter into a sucrose export mode providing the fungus with sugar from the phloem. Importantly, the high sucrose concentration in the phloem appeared disadvantageous for the ZmSUT1, preventing sucrose recovery from the apoplastic space in the fungus/plant interface. | Anke Wittek Ingo Dreyer Khaled A.S. Al-Rasheid Norbert Sauer Rainer Hedrich Dietmar Geiger | 2017 | Journal of Integrative Plant Biology2017,59,6: | 6 |
| 7 | 颈动脉Gadofosveset增强MR血管成像:稳态MR成像能否提高首次通过成像的准确性?与选择性DSA的比较显示文摘目的以DSA为参照标准,评价Gadofosveset增强MR血管成像对评估颈动脉狭窄的准确性,评价阅读首过、稳态及二者联合MR血管成像的价值。方法本研究经地方伦理委员会批准,并且所有参与者均签署知情同意书。84例(男56例,女28例;年龄61~76岁)超声下显示颈动脉狭窄的病人进行了MRA和DSA检查。3名阅片者评价首过、稳态及二者联合的MR血管成像表现,另有1名独立观察者评价DSA影像。主要评价颈动脉狭窄程度、斑块形态、溃疡形成、 | M. Anzidei A. Napoli B.C. Marincola I. Nofroni D. Geiger F. Zaccagna 张晓东(译) 夏爽(校) | 2009 | 国际医学放射学杂志2009,32,4: | 6 |
| 8 | Towards maximized utilization of iridium for the acidic oxygen evolution reaction显示文摘The reduction in noble metal content for efficient oxygen evolution catalysis is a crucial aspect towards the large scale commercialisation of polymer electrolyte membrane electrolyzers.Since catalytic stability and activity are inversely related,long service lifetime still demands large amounts of low-abundant and expensive iridium.In this manuscript we elaborate on the concept of maximizing the utilisation of iridium for the oxygen evolution reaction.By combining different tin oxide based support materials with liquid atomic layer deposition of iridium oxide,new possibilities are opened up to grow thin layers of iridium oxide with tuneable noble metal amounts.In-situ,time-and potential-resolved dissolution experiments reveal how the stability of the substrate and the catalyst layer thickness directly affect the activity and stability of deposited iridium oxide.Based on our results,we elaborate on strategies how to obtain stable and active catalysts with maximized iridium utilisation for the oxygen evolution reaction and demonstrate how the activity and durability can be tailored correspondingly.Our results highlight the potential of utilizing thin noble metal films with earth abundant support.materials for future catalytic applications in the energy sector. | Marc Ledendecker Simon Geiger Katharina Hengge Joohyun Lim Serhiy Cherevko Andrea M. Mingers Daniel Gohl Guilherme V. Fortunato Daniel Jalalpoor Ferdi Schuth Christina Scheu Karl J. J. Mayrhofer | 2019 | Nano Research2019,12,9: | 6 |
| 9 | 兔骨髓基质干细胞促进珊瑚骨成骨的实验研究显示文摘目的探讨运用组织工程技术合成自体骨移植的替代物的可行性。方法从兔骨髓中分离基质干细胞进行体外培养扩增后,载人明胶海绵或珊瑚骨制成复合物。取24只6~9个月龄雌性新西兰白兔,随机分成四组,每组6只。第1组桡骨干中段15mm的骨缺损内植入明胶海绵,第2组植入明胶海绵+骨髓基质干细胞(BMSCs),第3组植入珊瑚骨,第4期植入珊瑚骨+BMSCs,对各组动物进行影像学、p,CT和组织学比较。结果仅植入明胶海绵的骨缺损全部形成典型的骨折不愈合表现;植入明胶海绵+BMSCs后,骨缺损内的新骨形成明显增多,但仅有1只动物完全愈合;植入珊瑚骨后,骨缺损内有部分新骨形成,但术后16周无一例完全愈合;植入珊瑚骨+BMSCs后,骨缺损内的载体支架被逐渐吸收的同时有大量的新骨形成,其中4只动物完全愈合。结论由体外分离和培养的BMSCs与珊瑚骨合成的组织工程骨具有可吸收性强、成骨能力好等特点,是一种具有发展前景的自体骨移植材料替代物。 | 许伟华 杨述华 Geiger Florian | 2007 | 中华创伤骨科杂志2007,9,12: | 5 |
| 10 | 活体牙周膜有限元仿真的可行性研究显示文摘目的通过现代有限元方法研究牙周膜上的静平衡应力状态。方法提出了两种用于分析牙周膜应力状态的有限元方法,把牙周膜看做是整个下颌模型的一部分,通过有限元方法来处理仿真的牙齿并加载,来研究牙周膜对牙周组织的应力应变分布的作用,计算得到的静平衡应力和牙齿根吸收状态进行比较。结果牙周膜的最大应力发生在接近最高点位置,在中跟位置附近存在局部最大应力,而牙周膜顶点区域的应力要大于牙周膜中根附近的局部最大应力。齿槽顶部的舌侧牙周膜部位可以发现静平衡应力。静平衡应力是和位置有关的,有静平衡应力的部位就会发生牙根吸收。结论人类切牙和单根前臼齿一样,植入物会导致其牙周膜顶点附近静平衡应力的增长,这一点同之前的发现相一致。人类切牙根吸收经常作用于牙周膜的顶点部位。 | Ansgar Hohmann Cornelia Kober Thomas Radtke Philippe Young Martin Geiger Andrew Boryor Christian Sander Franz Gunter Sander | 2008 | 医用生物力学2008,23,1: | 3 |
| 11 | C-Terminus-Mediated Voltage Gating of Arabidopsis Guard Cell Anion Channel QUAC1显示文摘在植物玩的阴离子 transporters 在体积规定的一个基本角色并且发信号。当前,二血浆知道的定位膜的阴离子隧道 familiesSLAC/SLAH 和 ALMTare。在 ALMT 家庭之中,表示根的激活铝的 Malate Transporter 1 被铝容忍、 Al3+ 敏感的小麦栽培变种的比较识别并且随后被显示调停电压无关的 malate 电流。相反, ALMT12/QUAC1 (快速激活的阴离子 Channel1 ) 在搬运 malate 在的警卫房间被表示一 Al3+ 感觉迟钝并且高度电压依赖者举止。到目前为止,没有信息关于有 QUAC1 隧道蛋白质的电压依赖者 gating 的结构和机制是可得到的。这里,我们在揭示类似的电压相关性和 activationdeactivation 动力学的警卫房间和表示 QUAC1 卵母细胞的血浆膜分析了 QUAC1 类型电流的 gating。在 heterologous 表达式系统, QUAC1 electrophysiologically 在增加被描绘额外 -- 并且细胞内部的 malate 集中。从而, malate additively 刺激了电压依赖者 QUAC1 活动。寻找 gating 过程的结构的决定因素,我们不能识别为电压敏感的隧道普通的 transmembrane 领域。然而,在 QUAC1 的 C 终点的指导地点的变化和删除导致了改变的电压依赖者隧道活动。有趣地,由丙氨酸的单个 glutamate 残余的代替,从不同 clades 在 ALMT 隧道被保存,破坏了 QUAC1 活动。和标注的 C 终端和 N 终端,这些结果显示 cytosolic C 终点涉及 QUAC1 的电压依赖者 gating 机制。 | Patrick Mumm Dennis Imes Enrico Martinoia Khaled A.S. AI-Rasheid Dietmar Geiger Irene Marten Rainer Hedrich | 2013 | Molecular Plant2013,6,5: | 3 |
| 12 | Screening Options and Recommendations for Colorectal Cancer显示文摘 | Timothy Geiger Rocco Ricciardi | 2009 | Clinics in Colon and Rectal Surgery2009,,: | 2 |
| 13 | Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm显示文摘 | Jeffrey Bethony Simon Brooker Marco Albonico Stefan M Geiger Alex Loukas David Diemert Peter J Hotez | 2006 | The Lancet2006,,9521: | 2 |
| 14 | Influence of laser-produced microstructures on the tribological behaviour of ceramics显示文摘 | M. Geiger S. Roth W. Becker | 1998 | Surface & Coatings Technology1998,,: | 2 |
| 15 | GABA B Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K + Channels显示文摘 | Pan-Yue Deng Zhaoyang Xiao Chuanxiu Yang Lalida Rojanathammanee Laurel Grisanti John Watt Jonathan D. Geiger Rugao Liu James E. Porter Saobo Lei | 2009 | Neuron2009,,2: | 2 |
| 16 | Bayesian Network Classifiers显示文摘 | Nir Friedman Dan Geiger Moises Goldszmidt | 1997 | Machine Learning (-)1997,,2: | 2 |
| 17 | Elevated Serum Cyclophilin Levels in Patients with Severe Sepsis显示文摘 | I. Tegeder A. Schumacher S. John H. Geiger G. Geisslinger H. Bang K. Brune | 1997 | Journal of Clinical Immunology1997,,5: | 2 |
| 18 | 未来的可控配气机构元件显示文摘发动机配气机构领域众多的进展表明,主机厂和附件厂对技术创新有着浓厚的兴趣。介绍了INA-Schaeffler公司在与一些区域性特殊要求有关的可切换(双级可控)和完全可控(连续可控)配气机构产品方面的研发概况。 | Eggerath G | 2006 | 国外内燃机2006,38,6: | 2 |
| 19 | Process design for hydroforming of lightweight metal sheets at elevated temperatures显示文摘 | S. Novotny M. Geiger | 2003 | Journal of Materials Processing Tech2003,,1: | 2 |
| 20 | Metastasis mechanisms显示文摘 | Thomas R. Geiger Daniel S. Peeper | 2009 | BBA - Reviews on Cancer2009,,2: | 2 |