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| 1 | User Driven Innovation in the Building Process显示文摘During the late years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving due to introduction of advanced information and communication technology (ICT). The paper focuses on creative changes of the building process powered by user driven innovation activities. An overview of existing user driven innovation methodologies is given as well experiences from the ongoing Virtual Innovation in Construction (VIC) project. One important driving force for change is the opportunity for users to develop and articulate real needs concerning for example different functionalities of a building and its parts, but also on artifacts supporting the actual needs capture and requirements formulation during building design. A general methodological framework and meta ontology for Virtual Innovation in Construction is presented as well as findings from implementation of the method. | Per Christiansson Kistian Birch Sφrensen Mette Rφdtness Mette Abrahamsen Lars Ostenfeld Riemnann Morten Alsdorf | 2008 | Tsinghua Science and Technology2008，13，S1： | 4 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | Ultrasound Doppler system for two-dimensional flow mapping in liquid metals显示文摘 | Sven Franke Lars Büttner Jürgen Czarske Dirk R?biger Sven Eckert | 2010 | Flow Measurement and Instrumentation2010，，3： | 3 |
| 4 | Incidence and clinical course of Crohn’s disease during the first year — Results from the IBD Cohort of the Uppsala Region (ICURE) of Sweden 2005–2009显示文摘 | Daniel Sj?berg Tommy Holmstr?m M?rit Larsson Anne-Lie Nielsen Lars Holmquist Anders Ekbom Anders R?nnblom | 2014 | Journal of Crohn’s and Colitis2014，，3： | 2 |
| 5 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 6 | N -fertilization and soil acidification effects on N2O CO2and CO2 emission from temperate pine forest soil 显示文摘 | Bishal K S Lars R B Gunnar A | 1995 | Soil BiolBiochem1995，27，11： | 1 |
| 7 | 急性上消化道出血显示文摘每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。 | Emma Sverden Sheraz R Markar Lars Agreus Jesper Lagergren 龚亮(译) 吴东(校) 无 | 2019 | 英国医学杂志中文版2019，22，7： | 1 |
| 8 | Combined Interpretation of Fracture Zones In Crystalline Rock Using Single hole,Crosshole Tomography and Directional Borehole-radar Data显示文摘 | Sandberg E V Olsson O L Falk Lars R | 1991 | The Log Analyst1991，32，： | 1 |
| 9 | Facile labelling of an an- ti-epidermal growth factor receptor nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET显示文摘 | Maria J W Lars R P Rob C | 2011 | Eur J Nucl Med Mol Ima2011，，38： | 1 |
| 10 | Stoichiometric modeling of clostridium acetotutylicum fermentations with non-linear constraints显示文摘 | Desai R P Lars K Nielsen Papoutsakis E T | | 0，，01： | 1 |
| 11 | Hemodynamic assessment of acute stroke using dynamic single-slice computed tomographic perfusion imaging显示文摘 | Joachim R Lars J Anke F | 2000 | Arch Neurol2000，57，： | 1 |
| 12 | Do general practitioners act consistently in real practice when they meet the same patient twice? Examination of intradoctor variation using standardized (simulated) patients显示文摘 | Jan-joost R Lars S | 1997 | BMJ1997，314，： | 1 |
| 13 | The importance of pial blood supply to the development of peritumoral brain edema in meningiomas显示文摘 | Bitzer M Lars W Andreas R | 1997 | J Neurosurg1997，87，： | 1 |
| 14 | Norepinephrine induced changes in cardiac transforming growth factor? isoform expression pattern of female and male rats显示文摘 | WILFRIED B LARS H BEATE R | 2004 | Hypertension2004，44，： | 1 |
| 15 | Perfusion MR imaging for differentiation of benign and malignant meningiomas显示文摘 | Hao Zhang Lars A. R?diger Tianzhen Shen Jingtao Miao Matthijs Oudkerk | 2008 | Neuroradiology2008，，6： | 1 |
| 16 | Within-and between-stand distribution of attacks by pine weevil 显示文摘 | Lars W H Hans P R Jonas Geldmann | 2005 | Scandinavian Journal of Forest Research2005，20，： | 1 |
| 17 | A Case-study of Mesoscale Spectra of Wind and Temperature,Observed and Simulated显示文摘 | Larsén X G Larsen S R Badger M | 2011 | Quarterly Journal of the Royal Meteorological Society2011，137，654： | 1 |
| 18 | The type I interferon system in the development of lupus显示文摘 | Lars R?nnblom Gunnar V. Alm Maija-Leena Eloranta | 2011 | Seminars in Immunology2011，，2： | 1 |
| 19 | Gli genes and limb development显示文摘 | Thomas Theil Susanne Kaesler Lars Grotewold Jens B?se U. Rüther | 1999 | Cell & Tissue Research1999，，1： | 1 |
| 20 | Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians 显示文摘 | Kristina J Kaj T Lars R | 2002 | Chemosphere2002，46，： | 1 |
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