|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 2 | Net absorption and liver metabolism of amino acids and heat production of portaldrained viscera and liver in multiparous sows during transition and lactation显示文摘Background:Determination of nutrient requirements in the late gestating and lactating sows is essential to optimize sow productivity.The objectives of the present study were to quantify amino acid(AA)fluxes and heat production across portal-drained viscera(PDV)and liver in multiparous sows during transition and lactation.Methods:Eight second parity sows were fitted with indwelling catheters in the femoral artery and in the mesenteric,portal and hepatic veins.Eight hourly sets of blood samples were taken starting 0.5 h before feeding at−10,−3,+3,and+17 d in milk(DIM).Blood gases,plasma metabolites and apparent total tract digestibility(ATTD)of nutrients were measured.Results:Feed intake,the ATTD of DM,energy,nitrogen,fat and crude fiber changed with DIM(P<0.001).Except for Glu,O2,and urea,all net portal fluxes were positive,and all were affected by DIM(P<0.05)and by sampling time(P<0.01).Compared with pre partum levels,net portal uptake of AA was 3-63%lower at+3 DIM but 40-100%higher at+17 DIM.Net portal fluxes of AA peaked at 1.5 to 2.5 h after feeding except for Glu,and they were positively correlated with changes in sow feed intake across DIM.The net portal recovery was low for Met(49%),Thr(54%),and His(54%)and high for the remaining essential AA(63-69%)and none of them differed across DIM.Net hepatic uptake(i.e.hepatic oxidation)of Lys,Thr,Ile,Leu and Phe peaked at 0.5 to 2.5 h after feeding,whereas uptake of Trp,Val,and His was constant,while that of Met was close to zero.Conclusion:The net portal recovery was substantially lower for Met,Thr,and His than the remaining essential AA.Hepatic AA oxidation peaks 0.5 to 2.5 h after feeding.The heat production in PDV and liver was approximately two-fold higher at peak lactation compared to other stages.The study suggests that lysine was the limiting AA in peak lactation but not in early lactation. | Liang Hu Niels Bastian Kristensen Lianqiang Che De Wu Peter Kappel Theil | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 2 |
| 3 | Ferritins for Chemistry and for Life显示文摘 | Theil EC Behera RK Tosha T | 2013 | Coord Chem Rev2013，257，2： | 1 |
| 4 | A three-dimensional predictive active site model for lipase from Pseudomonas cepacia 显示文摘 | Lemke K Theil F Lemke M | 1997 | J Org Chem1997，62，18： | 1 |
| 5 | A sustainable solution for dietary iron deficiency through plant biotechnology and breeding to increase seed ferritin control显示文摘 | Theil E C Burton J W Beard J L | 1997 | European Journal of Clinical Nutrition1997，51，4： | 1 |
| 6 | Rotavirus-like,cali-civirus-like,and 23-nm virus-like particles associated with diar-rhea in young pigs显示文摘 | SAIF L J BOHL E H THEIL K W | 1980 | J Clin Microbiol1980，12，1： | 1 |
| 7 | Carebral and basilar artery thrombosis,following cervical spinal injury显示文摘 | Niedeggen A Rommel O Theile A | 1998 | Eentralbl Neurochir1998，60，1： | 1 |
| 8 | Nutritional strategies and growth in extremely low birth weight infants with bronehopulmo- nary dysplasia over the past 10 years 显示文摘 | Theile AR Radmacher PG Ansehutz TW | 2012 | J Perinatol2012，32，2： | 1 |
| 9 | Ferritin protein nanocages-the story显示文摘 | Theil EC | 2012 | Nanotechnol Percept2012，8，1： | 1 |
| 10 | 显示文摘 | Kusano E Theil J A | 1989 | J Vac Sci Technol1989，7，3： | 1 |
| 11 | Strategies for in-orbit calibration of drag-free control systems 显示文摘 | Guilherme M S Waldemar C L F Theil S | 2008 | Aerospace Science and Technology2008，12，5： | 1 |
| 12 | Cevebral and banilar artery thrembosis following cerrical spinal injury显示文摘 | Niedeggen A Rommel O Theile A | 1999 | J Neurochir1999，60，1： | 1 |
| 13 | Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a 显示文摘 | THEIL T MCLEAN-HUNTER S ZORNIG M | 1993 | Nucleic Acids Res1993，21，25： | 1 |
| 14 | Plant and microbial ferritin, and cellular func- tion in animals, plants and microorganisms 显示文摘 | Theil E C Hase T | 1993 | Annu Rev Bio- chem1993，56，： | 1 |
| 15 | On Pure and Mixed Statistical Estimation in Economics显示文摘 | Theil H Goldberger A S | 1961 | International Economic Review1961，，2： | 1 |
| 16 | Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women显示文摘 | Davila-Hicks P Theil E C Lonnerdal B | 2004 | Am J Clin Nutr2004，80，： | 1 |
| 17 | Cellular regulation and molecu- lar interactions of the ferritins显示文摘 | Hintze KJ Theil EC | 2006 | Cell Mol Life Sci2006，63，5： | 1 |
| 18 | On The Use of Incomplete Prior Information in Regression Analysis显示文摘 | Theil H | 1963 | Journal of The American Statistical Association1963，，58： | 1 |
| 19 | Free jejunal interposition reconstruction after pharyngolaryngectomy:201consective cases显示文摘 | Theile DR Robinson DW Theile DE | 1995 | Head Neck1995，17，： | 1 |
| 20 | 'Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assess- ment with existing methods' 显示文摘 | Poulin P Theil F | 2009 | J Pharm Sci2009，98，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员