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| 1 | 博莱霉素肺纤维化小鼠血管内皮细胞的研究显示文摘目的 :研究C57BL/ 6小鼠肺微小血管内皮细胞血栓调节蛋白 (TM)与因子Ⅷ相关抗原 (vWf)的分布及博莱霉素 (BLM)致肺纤维化过程中 ,血管内皮细胞亚型的转变。方法 :采用双重免疫荧光染色及荧光强度定量分析法。结果 :①正常C57BL/ 6小鼠肺泡毛细血管内皮细胞表面显示多数连续性线样TM荧光而vWf较少阳性 ,肺微小血管内皮细胞呈现vWf阳性。②BLM组小鼠内皮细胞TM荧光明显弱于正常 ,而vWf荧光显著强于正常水平。结论 :①正常C57BL/ 6小鼠肺泡毛细血管内皮细胞以TM表达为主型 ,而非vWf表达为主型。②BLM致肺纤维化过程中 ,肺血管内皮细胞由以TM表达为主型转变为以vWf表达为主型 。 | 姜莉 金恩京 Mohammad Ghazizadeh Oichi Kawanami | 2002 | 中国病理生理杂志2002，18，3： | 7 |
| 2 | Moxibustion Promotes Formation of Granulation in Wound Healing Process through Induction of Transforming Growth Factor-β in Rats显示文摘Objective:To examine the effect of moxibustion on the wound healing process and its mechanism using a rat wound model.Methods:Sixty male Sprague-Dawley rats were randomly divided into a sham-treated group(n=30,wound surgery only)and a moxibustion group(n=30,wound treated with moxibustion).Circular fullthick ness skin wounds were produced in rats.Moxibustion was applied to the edge of wound and was continued on alternating days till 14 days after surgery,followed by measurement of wound size.Expression of collagens,prolyl-4-hydroxylase(P4H)and transtorming growth factor-β(TGF-β)were evaluated by histochemical study and real-time polymerase chain reaction.Results:The size of the wound lesion was significantly reduced in rats treated with moxibustion as compared to that in sham-treated rats at 4-10 days after wounding(P<0.01).Moxibusti on stimulated mRNA expressi on of collage ns at 4 days(P<0.01),but not at 7 days,accompa nied by enhanced proliferation of P4H-positive fibroblasts.Of importanee,expression of TGF-β in tissue from the wound lesio n treated with moxibusti on was sign ifica ntly in creased as compared to that in sham-treated rats at 4 days(P<0.01 or P<0.05),but not at 7 days.Conclusions:The treatment with moxibustion promoted the wound healing process in the early phase through proliferation of fibroblasts and rapid formation of granulation,possibly mediated by induction of TGF-β which is a key molecule in the physiological process of wound healing.Moxibustion can be expected to be effective as complementary treatment for intractable ulcers. | Hiroshi Kawanami Hirohisa Kawahata Hiroko-Miyuki Mori Motokuni Aoki | 2020 | Chinese Journal of Integrative Medicine2020，26，1： | 3 |
| 3 | Lack of Cholecystokinin-A Receptor Enhanced Gallstone Formation: A Study in CCK-A Receptor Gene Knockout Mice显示文摘 | Norikazu Sato Kyoko Miyasaka Shinji Suzuki Setsuko Kanai Minoru Ohta Takako Kawanami Yuki Yoshida Soichi Takiguchi Tetsuo Noda Yutaka Takata Akihiro Funakoshi | 2003 | Digestive Diseases and Sciences2003，，10： | 2 |
| 4 | Extracellularsignal-regulated kinase 1 (ERK1) and ERK2 play essentialroles in osteoblast differentiation and in supporting osteoclas-togenesis显示文摘 | Matsushita T Chan YY Kawanami A | 2009 | Mol Cell Biol2009，29，： | 1 |
| 5 | Characteristics of methoxycarbonylation of aromatic diamine with dimethyl carbonate to dicarbamate using a zinc acetate catalyst显示文摘 | Baba T Kobayashi A Kawanami Y | 2005 | Green Chemistry2005，7，3： | 1 |
| 6 | ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells显示文摘 | Yamano G Funahashi H Kawanami O | 2001 | FEBS Lett2001，508，2： | 1 |
| 7 | Development of an oral drug delivery systemtargeting immune-regulating cells in experimentalinflammatory bowel disease: a new therapeutic strategy显示文摘 | Nakase H Okazaki K Tabata Y Uose S Ohana M Uchida K Matsushima Y Kawanami C Oshima C IkadaY Chiba T | 2000 | Journal of Pharmacology and ExperimentalTherapeutics2000，292，1： | 1 |
| 8 | A Japanese adult case of megalencephalic leukoencephalopathy with subcortical cysts with a good long-term prognosis显示文摘 | Koyama S Kawanami T Arawaka S | 2012 | Intern Med2012，51，5： | 1 |
| 9 | Chemical fixation of carbon dioxide to styrene carbonate under supercritical conditions with DMF in the absence of any additional catalysts 显示文摘 | Kawanami H Ikushima Y | 2000 | Chemical Communications2000，21，： | 1 |
| 10 | Direct reciprocal effects of resistin and adioponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions显示文摘 | Kawanami D Maemura K Takeda N | 2004 | Biochem Biophys Res Commun2004，314，2： | 1 |
| 11 | A rapid and effective synthesis of propylene carbonate using a supercritical CO2-ionic liquid system显示文摘 | Kawanami H Sasaki A Matsui K | 2003 | ChemicalCommunications2003，7，： | 1 |
| 12 | A rapid and effective synthesis of propylene carbonate using a supereritieal CO2 ionic liquid system 显示文摘 | Kawanami H Sasaki A Matsui K | 2003 | Chemical Communications2003，，8： | 1 |
| 13 | The myeloid tran- scription factor KLF2 regulates the host response to polymicrobial in- fection and endotoxic shock 显示文摘 | Mahabeleshwar GH Kawanami D Sharma N | 2011 | Immunity2011，34，5： | 1 |
| 14 | Solidification Characteristics of a Droplet on a Horizontal Cooled Wall显示文摘 | KAWANAMI T YAMADA M FIKUSAKO S | 1997 | Heat Transfer-Japanese Research1997，26，7： | 1 |
| 15 | Involvement of beta-adrenergic receptor kinase-1inhomologous desensitization of histamine H2receptors in human gastric carcinoma cell line MKN-45显示文摘 | Nakata H Kinoshita Y Kishi K Fukuda H Kawanami C Matsus-hima Y | 1996 | Digestion1996，57，6： | 1 |
| 16 | Familial normal pressure hydrocephalus(NPH)with an autosomal-dominant inheritance:A novel subgroup of NPH显示文摘 | Takahashi Y Kawanami T Nagasawa H | 2011 | J Neurol Sci2011，308，12： | 1 |
| 17 | Effect of lifestyle on periodontal disease status in diabetic patients 显示文摘 | Negishi J Kawanami M Terada Y | 2004 | J Int Acad Periodontol2004，6，4： | 1 |
| 18 | Oral health care-specific self-efficacy assessment predicts patient completion of periodontal treatment:a pilot cohort study显示文摘 | Kakudate N Morita M Kawanami M | 2008 | J Periodontol2008，79，6： | 1 |
| 19 | Lateral and medial medullary infarction: a comparative analysis of 214 patients显示文摘 | KAMEDA W KAWANAMI T KURITA K | 2004 | St roke2004，35，3： | 1 |
| 20 | Upper midbrain profile sign and cingulate sulcus sign: MRI findings on sagittal images in idiopathic normal-pressure hydrocephalus, Alzheimer's disease, and progressive supranuclear palsy显示文摘 | Adachi M Kawanami T Ohshima F | 2006 | Radiat Med2006，24，8： | 1 |
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