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| 1 | A^200 ka pollen record from Okinawa Trough:Paleoenvironment reconstruction of glacial-interglacial cycles显示文摘Pollen analysis was carried out on the Core MD982194 of 29.78 m retrieved from the Middle Okinawa Trough which was dated as old as^200 ka BP.The results revealed that pollen assemblages mainly presented an alternation of coniferous and herb pollen.The coniferous saccate pollen,principally Pinus and Tsuga,predominated in most parts of the core,especially highlighted in the interstadial stages including MIS 1,3,5 and MIS7,whereas the herb pollen significantly increased in the glacial periods.Thus the pollen flora and their percentages showed the sensitive changes under the influence of ice volume during the glacial and interglacial periods.Our record from this core has first documented that the percentage of Cyperaceae was extremely high in the glacial stages with a notable increase in Artemisia,Gramineae,Asteraceae,Chenopodiaceae,and freshwater algae,which can be used as a proxy for sea-level change at the study site because of their close negative correlation of the orbital-scale changes in sea level.The distance between the continental coastline and the Okinawa Trough has deeply shortened due to the sea-level drop in the LGM.As a result,the sediment materials from Yangtze River were extensively deposited on the flat,exposed continental shelf owing to the rapid decline of river flow speed,leading to that pollen grains from Okinawa Trough are derived mainly from the flat coastal vegetation of exposed continental shelf at glacial stages.Changes of pollen assemblage were consistent with the variation of temperature and humidity,which showed that the percentage of arboreal pollen was highly augmented at MIS 7,5 and MIS 1,corresponding to the strengthening of the East Asian summer monsoon and increasing of rainfall.Moreover,the peak of Pinus percentage in MIS 5.3,5.1 and MIS 3.3 may be closely linked by orbital and sub-orbital cycles of solar radiation and monsoonal variability.The present study of core MD981294 implied lower temperature and precipitation during the lowest sea-level stage(LGM),and more visibly testified that the vegetation of the flat plain on the exposed continental shelf was dominated by intrazonal communities such as halophyte grasslands and freshwater wetlands instead of zonal steppe or semi-arid desert.All above evidence demonstrated that the fundamental changes of pollen assemblage and their origins in Okinawa Trough since^200 ka BP were affected by combine factors including the coastline position and climate fluctuation.Moreover,the substantial shortening of distance between shoreline and the Okinawa Trough driven by orbital insolation cycles was clearly indicated by the pollen spectra,whereas the source-area climate signal of the pollen record was largely weakened. | ZHENG Zhuo HUANG KangYou DENG Yun CAO LingLong YU ShaoHua Jean-Pierre SUC Serge BERNE Franois GUICHARD | 2013 | Science China Earth Sciences2013，56，10： | 11 |
| 2 | 冲绳海槽200ka的孢粉记录及冰期-间冰期旋回古环境重建显示文摘本文对冲绳海槽中部MD982194钻孔29.78m近200kaBP的岩芯进行了孢粉研究.结果表明,孢粉组合主要表现为裸子植物与草本植物花粉之间的交替.带气囊类的松属、铁杉在间冰期的1,3,5和7氧同位素期显著增高,而草本则在冰期阶段占优,两者的含量变化显示出对冰期-间冰期环境变化的敏感响应.本钻孔发现莎草科花粉在冰期阶段含量大幅度增加,伴随蒿属、禾本科、菊科、藜科和淡水藻类的显著升高.它们与轨道尺度的海平面变化呈现十分吻合的负相关关系.草本花粉总量的周期性变化可以作为该区域海平面变化的替代性指标.末次盛冰期的海平面下降导致陆地与冲绳海槽的距离大幅缩小,源于长江的物质随河流进入大陆架后因流速急剧降低发生沉降,导致上游物质难以被远距离搬运到海槽.因此,冰期阶段冲绳海槽的孢粉物质可能主体来自于大陆架前缘的地表植被,而间冰期带气囊类花粉的比例增大与海岸距离较远和风力搬运物质的比例增加有关.钻孔的孢粉组分更替与气候变化也有显著的对应关系,反映出氧同位素7,5和1期木本含量高,并与东亚夏季风增强和降雨量增大有关.其中MIS5.3,MIS5.1和MIS3.3段的松属花粉峰值可能与轨道和亚轨道周期的地表太阳辐射和季风增强有密切联系.研究认为,盛冰期的东海陆架平原的气温和降雨量都有较明显的下降,但低海面时期裸露的大陆架平原可能并非由半干旱的地带性草原所覆盖,而是以疏林草地及密布的隐域性植被(河流补给淡水湖沼和湿地)组成.海平面变化引起的海岸距离伸缩和源区气候变化对陆源物质通量和孢粉组分更替起到联合制约的作用,而冲绳海槽冰期-间冰期尺度的海岸线距离变化在孢粉信号中的表现要明显强于陆源区域的气候变化. | 郑卓 黄康有 邓韫 曹玲珑 余少华 Jean-Pierre SUC Serge BERNE Francois GUICHARD | 2013 | 中国科学:地球科学2013，43，8： | 10 |
| 3 | 冲绳海槽末次盛冰期孢粉组合的古环境指示意义显示文摘冲绳海槽西陆坡末次冰期的高沉积速率为高分辨率研究提供了良好的材料,DGKS-9602钻孔通过氧同位素年代对比,总长931 cm的岩心保存了相当于氧同位素阶段1~3的沉积记录.孢粉分析的结果表明,OIS 1和OIS三阶段松属花粉含量占优势,平均含量达65%以上,而OIS 2阶段松属百分含量明显降低,草本植物花粉含量增加,超过50%.松属与蒿属等草本花粉间的相互消长指示了海平面的升降,并与氧同位素曲线的变化趋势相似.末次盛冰期中国东部大陆架覆盖的植被以草地为主,由于冲绳海槽在末次盛冰期时的绝大部分沉积物质与大陆架的剥蚀作用有关,来自长江中上游山地较远距离带来的物质和山地花粉相对减少.与中国东部尘土花粉结果对比发现,现代东海表层蒿属与禾本科比值(A/P)所指示的纬度正好与长江中下游平均纬度相当,而冲绳海槽末次盛冰期的A/P比值所指示的陆地环境比现代高7个纬度,证明末次盛冰期植被带南移,与前人陆地记录的结果相吻合. | 邓韫 郑卓 Suc J.P. Berne S. | 2005 | 地球科学(中国地质大学学报)2005，30，5： | 9 |
| 4 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 5 | Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy显示文摘BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological criteria.More recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor cells.AIM To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after NAC.METHODSFrom January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt TRG.Based on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were performed.RESULTS Seventy-four patients were classified as responders and 76 as non-responders.The postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological response.Three were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 yr.The factors contributing to a poor prognosis for disease-free survival were: No histological response after NAC, largest metastasis > 3 cm, more than three preoperative metastases, R1 resection, and the use of a targeted therapy with NAC(P < 0.005).CONCLUSION A non-radiological response and a number of NAC sessions > 7 are the two most pertinent predictive factors of non-histological response(TRG 4 or 5). | Chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie Berard Fabrice Muscari | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 4 |
| 6 | Contribution of alpha-fetoprotein in liver transplantation for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma(HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its contribution in liver transplantation for HCC has not been fully determined, although its use to predict recurrence after liver transplantation has been underlined by international societies. In an era of organ shortages, it could also have a key role in the selection of patients eligible for liver transplantation. Yet unanswered questions remain. First, the cut-off value of serum AFP above which liver transplantation should not be performed is still a subject of debate. We show that a concentration of 1000 ng/m L could be an exclusion criterion, whereas values of < 15 ng/m L indicate patients with an excellent prognosis whatever the size and number of tumors. Monitoring the dynamics of AFP could also prove useful. However, evidence is lacking regarding the values that should be used. Today, the real input of AFP seems to be its integration into new criteria to select patients eligible for a liver transplantation. These recent tools have associated AFP values with morphological criteria, thus refining pre-existing criteria, such as Milan, University of California, San Francisco, or 'up-to-seven'. We provide a review of the different criteria submitted within the past years. Finally, AFP can be used to monitor recurrence after transplantation, although there is little evidence to support this claim. Future challenges will be to draft new international guidelines to implement the use of AFP as a selection tool, and to determine a clear cut-off value above which liver transplantation should not be performed. | Bérénice Charrière Charlotte Maulat Bertrand Suc Fabrice Muscari | 2016 | World Journal of Hepatology2016，8，21： | 3 |
| 7 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy 显示文摘 | Duffas JP Suc B Msika S | 2005 | Am J Surg2005，189，6： | 1 |
| 8 | Octreotide in the prevention of intra-abdominal complications following elective pancreatic resection : a prospective, multicenter randomized controlled trial 显示文摘 | Suc B Msika S Piceinini M | 2004 | Arch Surg2004，139，3： | 1 |
| 9 | Orthotopic Liver Transplantation with Vena Cava Preservation in Cirrhotic Patients:is Systematic Temporary Portacaval Anastomosis a Justified Procedure?显示文摘 | MUSCARI F SUC B AGUIRRE J | 2005 | Transplant Proc2005，37，2： | 1 |
| 10 | Temporary Fibrin Glue Occlusion of the Main Pancreatic Duct in the Prevention of Intra-Abdominal Complications After Pancreatic Resection显示文摘 | Bertrand Suc Simon Msika Abe Fingerhut | 2003 | Ann Surg2003，237，1： | 1 |
| 11 | Towards the lowering of the pliocene/Pleistocene boundary to the GaussMatuyama reversal显示文摘 | Suc J P Bertini A Leroy S A | 1997 | Quaternary International1997，40，： | 1 |
| 12 | A controlled randomized multicentertrail of pancreatogastrostomy or pancreatojejunosto- my after pancreatoduodenectomy 显示文摘 | DUFAS J P SUC B MSIKA S | 2005 | Am J Surg2005，189，6： | 1 |
| 13 | Temporary fibrin glue occlusion of the main pancreatic duct in the prevention of intra-abdominal complication after pancreatic resection: Prospective randomial trial显示文摘 | Suc B Msika S Fingrhut A | 2003 | Ann Surg2003，237，1： | 1 |
| 14 | Risk factors for mortality and intra-abdominal complications after pancreatoduodenectomy : multivariate analysis in 300 patients显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，： | 1 |
| 15 | Expression of Ki-67 and p27(Kip1)in fine-needle aspirates from breast carcinoma and benign breast diseases显示文摘 | Ramljak V Sucˇic'M Vrdoljak DV | 2011 | Diagn Cytopathol2011，39，5： | 1 |
| 16 | Temporary fibrin glue occlusion of the main pancreatic duct in the prevention of intra - abdominal complication after pancreatic resection: prospective randomial trial 显示文摘 | Suc B Msika S Fingerhut A | 2003 | Ann Surg2003，237，1： | 1 |
| 17 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy 显示文摘 | Duffas JP Suc B Msika S | 2005 | Am J Surg2005，189，6： | 1 |
| 18 | Catalytic performance of core-shell and alloy Pd-Au nanoparticles for total oxidation of VOC: The effect of metal deposition显示文摘 | HOSSEINI M BARAKAT T COUSIN R ABOUKAIS A SUC B-L DE WEIRELD G SIFFERT S | 2012 | Appl Catal B: Environ2012，，： | 1 |
| 19 | Risk factors for mortality and intra-abdominal complications after pancreatoduodenectomy: multivariate analysis in 300 patients 显示文摘 | Muscari F Suc B Kirzin S | 2006 | Surgery2006，139，5： | 1 |
| 20 | A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreatoduodenectomy显示文摘 | Duffas JP Suc B Msika S | | 0，，06： | 1 |
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