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| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 2 | 心肌梗死第三次全球统一定义显示文摘心肌梗死的定义
急性心肌梗死的诊断标准
临床存在心肌缺血并有心肌坏死的证据时,应当使用“心肌梗死”这一术语。此时出现下列任一项均可诊断心肌梗死: | Thygesen K Alpert JS Jaffe AS 陈阳(节译) 徐兆龙(节译) 刘仁光(节译) | 2013 | 辽宁医学院学报2013，34，1： | 13 |
| 3 | Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats显示文摘Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r esponses.With the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo rs.Fisher rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor bed.Intracranially inoculated DCs were found to drain to ipsilateral deep cervical lymph nodes.This was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic lymphocytes.DC therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch allenge.These results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma. | Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS | 2003 | 癌症2003，22，7： | 8 |
| 4 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 5 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory显示文摘 | Lee HK Takamiya K Han JS | 2003 | Cell2003，112，5： | 1 |
| 8 | Structure characterization of normal and mutant human steroid 17α-hydroxylase gene:molecular basis of one example of combined 17α-hydroxylase and 17,20-lyase deficiency显示文摘 | Kagimoto M Winter JS Kagimoto K | 1988 | Mol Endocrinol1988，2，6： | 1 |
| 9 | Insulin secretion and sensitivity in women fulfilling WHO criteria for gestational diabetes显示文摘 | Nicholls JS Chan SP Ali K | 1995 | Dia-bet Med1995，12，1： | 1 |
| 10 | Simulation of target detection in ultraviolet and infrared bands显示文摘 | DOO K S OH JS JAHNG S G | 2001 | Opt Eng2001，40，11： | 1 |
| 11 | Adjuvant carboplatin and paclitaxel chemotherapy interposed with involved field radiation for advanced endometrial cancer显示文摘 | Lupe K D'Souza DP Kwon JS | 2009 | Gynecol Oncol2009，114，1： | 1 |
| 12 | Reducing hypertriglyceridem in elderly patients with cerebrovascular disease stabilizes or improves cognition and cerebral perfusion显示文摘 | Rogers RL Meyer JS Mcchintic K | 1989 | Angiology1989，40，： | 1 |
| 13 | A randomized phase Ⅲ study of Gefitinib versus standard chemotherapy (Gemcitabine plus Cisplatin) as a first-line treatment for never-smokers with advanced or metastatic adenocarcinoma of the lung显示文摘 | Lee JS Park K Kim SW | 2009 | J Thorac Oncol2009，，： | 1 |
| 14 | Strengthening the Interna-tional Health Regulations:lessons from the H1N1 pandemic显示文摘 | Wilson K Brownstein JS Fidler DP | | Health Policy Plan0，25，6： | 1 |
| 15 | Stereotactic delivery of a recombinant adenovirus into a C6 glioma cell line in a rat tumor model 显示文摘 | Badie B Hunt K Economou JS | 1994 | Neurosurgery1994，35，5： | 1 |
| 16 | Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production显示文摘 | Millar JS Maugeais C Ikewaki K Kolansky DM Barrett PH Budreck EC | 2005 | Arcterioscler Thromb Vasc Biol2005，25，3： | 1 |
| 17 | Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease显示文摘 | Marjolein L Michael K Andrew JS | 2002 | Circ J2002，106，1： | 1 |
| 18 | Expreesion of pituitary tumor transforming gene (PTTG) and fibroblast growth factor - 2 (FGF- 2) in human pituitary adenomas: relationships to clinical tumour behaviour 显示文摘 | McCabe CJ Khaira JS Boelaert K | | Clin Endocrinol (Oxf)0，58，2： | 1 |
| 19 | Calcium Oxalate is Associated with Benign Breast Tissue:Can we Avoid Biopsy显示文摘 | Winston JS Yeh IT Evers K | 1993 | Am J Clin Pathol1993，100，5： | 1 |
| 20 | Myocardial infarction redefined:aconsensus document of the joint European society of cardiology/American college of cardiology committee for the re-definition of myocardial infarction 显示文摘 | Alpert JS Thygesen K Antman E | 2008 | J Am Coil Cardlol2008，36，： | 1 |
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