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| 1 | White light endoscopy,narrow band imaging and chromoendoscopy with magnification in diagnosing colorectal neoplasia显示文摘AIM:To evaluate the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of 3 different techniques:high resolution white light endoscopy(WLE),Narrow Band Imaging(NBI) and Chromoendoscopy(CHR),all with magnification in differentiating adenocarcinomas,adenomatous and hyperplastic colorectal polyps.METHODS:Each polyp was sequentially assessed first by WLE,followed by NBI and finally by CHR.Digital images of each polyp with each modality were taken and stored.Biopsies or polypectomies were then performed followed by blinded histopathological analysis.Each image was blindly graded based on the Kudo's pit pattern(KPP).In the assessment with NBI,the mesh brown capillary network pattern(MBCN) of each polyp was also described.The Sn,Sp,PPV and NPV of differentiating hyperplastic(Type Ⅰ & Ⅱ-KPP,Type Ⅰ-MBCN) adenomatous(Types Ⅲ,Ⅳ-KPP,Type Ⅱ-MBCN) and carcinomatous polyps(Type Ⅴ-KPP,Type Ⅲ-MCBN) was then compared with reference to the final histopathological diagnosis.RESULTS:A total of 50 colorectal polyps(5 adenocarcinomas,38 adenomas,7 hyperplastic) were assessed.CHR and NBI [KPP,MBCN or the combined classification(KPP & MBCN)] were superior to WLE in the prediction of polyp histology(P < 0.001,P=0.002,P=0.001 and P < 0.001,respectively).NBI,using the MBCN pattern or the combined classification showed higher numerical accuracies compared to CHR,but this was not statistically significant(P=0.625,0.250).CONCLUSION:This feasibility study demonstrated that this combined classification with NBI could potentially be useful in routine clinical practice,allowing the endoscopist to predict histology with higher accuracies using a less cumbersome and technically less challenging method. | Rajvinder Singh Victoria Owen Anthony Shonde Philip Kaye Christopher Hawkey Krish Ragunath | 2009 | World Journal of Gastrointestinal Endoscopy2009，1，1： | 3 |
| 2 | Diagnosis of autoimmune gastritis by high resolution magnification endoscopy显示文摘胃的萎缩的内视镜的可视化通常不与常规内视镜检查法是可行的。放大内视镜检查法是有用的分析潜水艇没有织物的上皮的微脉管的建筑学以及粘膜表面微观结构活体检视。用这种技术,我们能描述正常胃的微脉管系统模式,我们也在自体免疫的萎缩性胃炎的二种情况中识别了典型模式。 | George K Anagnostopoulos Krish Ragunath Anthony Shonde Christopher J Hawkey | 2006 | World Journal of Gastroenterology2006，12，28： | 3 |
| 3 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 4 | Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use显示文摘 | Loren Laine Laurine G. Connors Alise Reicin Christopher J. Hawkey Ruben Burgos–Vargas Thomas J. Schnitzer Qinfen Yu Claire Bombardier | 2003 | Gastroenterology2003，，2： | 1 |
| 5 | Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells显示文摘AIM: To study the mechanisms by which Campylobacter jejuni (C. jejuni) causes inflammation and diarrhea. In particular, direct interactions with intestinal epithelial cells and effects on barrier function are poorly under- stood. METHODS: To model the initial pathogenic effects of C. jejuni on intestinal epithelium, polarized human colonic HCA-7 monolayers were grown on permeabilized filters and infected apically with clinical isolates of C. jejuni. Integrity of the monolayer was monitored by changes in monolayer resistance, release of lactate dehydrogenase, mannitol fluxes and electron microscopy. Invasion of HCA-7 cells was assessed by a modified gentamicin protection assay, translocation by counting colony forming units in the basal chamber, stimulation of mediator release by immunoassays and secretory responses in monolayers stimulated by bradykinin in an Ussing chamber. RESULTS: All strains translocated across monolayers but only a minority invaded HCA-7 cells. Strains that invaded HCA-7 cells destroyed monolayer resistance over 6 h, accompanied by increased release of lactate dehydrogenase, a four-fold increase in permeability to [3H] mannitol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not. CONCLUSION: These data demonstrate two distinct effects of C. jejuni on colonic epithelial cells and provide an informative model for further investigation of initial host cell responses to C. jejuni. | Johannes Beltinger Jo del Buono Maeve M Skelly John Thornley Robin C Spiller William A Stack Christopher J Hawkey | 2008 | World Journal of Gastroenterology2008，14，48： | 1 |
| 6 | Efficacy of New Playback Functions at Reducing Small-Bowel Wireless Capsule Endoscopy Reading Times显示文摘 | Venkataraman Subramanian Jayan Mannath Emmanouil Telakis Krish Ragunath Christopher Hawkey | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 7 | Efficacy of New Playback Functions at Reducing Small-Bowel Wireless Capsule Endoscopy Reading Times显示文摘 | Venkataraman Subramanian Jayan Mannath Emmanouil Telakis Krish Ragunath Christopher J. Hawkey | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 8 | Nonsteroidal anti-inflanunatory drug gastropathy显示文摘 | Christopher J Hawkey | 2000 | Gastroenterology2000，119，2： | 1 |
| 9 | 上消化道出血的临床评估:如何评分?显示文摘急性上消化道出血是胃肠病学专家最常遇到的危及生命的内科急症,其年发病率为50/10万-10万^1[1]。上消化道出血死亡率也稳居高位(1995年为14%), | Venkataraman Subramanian Christopher J Hawkey | 2009 | 世界临床医学2009，，7： | 0 |
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