|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection显示文摘 | Nezam Afdhal Stefan Zeuzem Paul Kwo Mario Chojkier Norman Gitlin Massimo Puoti Manuel Romero-Gomez Jean-Pierre Zarski Kosh Agarwal Peter Buggisch Graham R. Foster Norbert Br?u Maria Buti Ira M. Jacobson G. Mani Subramanian Xiao Ding Hongmei Mo Jenny C. Ya | 2014 | The New England Journal of Medicine2014，，： | 6 |
| 2 | Developing a donation after cardiac death risk index for adult and pediatric liver transplantation显示文摘AIM To identify objective predictive factors for donor after cardiac death(DCD) graft loss and using those factors, develop a donor recipient stratification risk predictive model that could be used to calculate a DCD risk index(DCD-RI) to help in prospective decision making on organ use.METHODS The model included objective data from a single institute DCD database(2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added to the model via forward selection, significance level P = 0.3. The warm ischemic threshold was clinically set at 30 min. Points were given to each predictor in proportion to their hazard ratio. Using this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk and respective graft survival calculated.RESULTS DCD graft survival predictors were primary indication for transplant(P = 0.066), retransplantation(P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) and donor hepatectomy time > 60 min(P = 0.028).According to the calculated DCD-RI score three risk classes could be defined of low(DCD-RI < 1), standard(DCD-RI 2-4) and high risk(DCD-RI > 5) with a 5 years graft survival of 86%, 78% and 34%, respectively.CONCLUSION The DCD-RI score independently predicted graft loss(P < 0.001) and the DCD-RI class predicted graft survival(P < 0.001). | Shirin Elizabeth Khorsandi Emmanouil Giorgakis Hector Vilca-Melendez John O'Grady Michael Heneghan Varuna Aluvihare Abid Suddle Kosh Agarwal Krishna Menon Andreas Prachalias Parthi Srinivasan Mohamed Rela Wayel Jassem Nigel Heaton | 2017 | World Journal of Transplantation2017，7，3： | 3 |
| 3 | Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro显示文摘Macrophages play a crucial role in initiating,maintaining,and resolving inflammation through the phenotypic shift,inducing or inhibiting the production of inflammatory cytokines.Therefore,macrophages are potential targets for treating inflammatory diseases.Andrographolide(AND)is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB/MAPK pathway in activated macrophages.Although AND has many medicinal properties,its lower water solubility and first-pass effect in the liver have hindered its clinical application.In this context,by using a metal phenolic network as a stabilizer,we designed and prepared highly stabilized AND nanocrystals(AND-MPN Ns)with high drug loading capacity to facilitate the clinical application of AND.Our findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization,reducing proinflammatory cytokines IL-6 and TNF-α,and suppressing the NF-κB signaling pathway activation.The results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively. | Kosheli Thapa Magar George Frimpong Boafo Makhloufi Zoulikha Xiaohong Jiang Xiaotong Li Qingqing Xiao Xuyang Xing Xiaochun Wang Lifang Fan Zhenfeng Wu Wei He | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 4 | NADPH-dependent metabolism of estrogen by human liver microsomes显示文摘 | Lee A J Mills L H Kosh J W | | 0，，03： | 1 |
| 5 | Erythropoietin-induced neurovascu- lar protection, angiogenesis, and cerebral blood flow resrotation after focal isehemia in mice显示文摘 | Li Y Lu Z Kosh CL | 2007 | J Cereb Blood Flow Metab2007，27，5： | 1 |
| 6 | An introduction to practical illumination engineering显示文摘 | KOSHE R J | 2006 | Light Pipe Design2006，4，2： | 1 |
| 7 | Liposome-based delivery of biological drugs显示文摘Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membranepermeability, low stability, and larger size. Liposome-based drug delivery systems are emerging as promising tools to improve their delivery, owing to their ability to reduce toxicity, improve bioavailability,and enhance the therapeutic efficacy of the drug by optimizing delivery to the specific target site. Here,we reviewed the types of liposomes and their applications as carriers for biological drugs to treat various diseases, emphasized the commercial products, and ultimately provided perspectives in this field. | Kosheli Thapa Magar George Frimpong Boafo Xiaotong Li Zhongjian Chen Wei He | 2022 | Chinese Chemical Letters2022，33，2： | 1 |
| 8 | Novel repair for obstructed total anomalous pulmonary venous connection to coronary sinus 显示文摘 | Kosh S Kumar RK Gururja RS | 2005 | Ann Thorac Surg2005，79，： | 1 |
| 9 | Novel repair for obstructed total anomalous pulmonury venous connection to oronary Sinus显示文摘 | Kosh S Kumar pK Gururja RS | | 0，，： | 1 |
| 10 | Liver transplantation in patients over 60 and 65 years: An evaluation of long‐term outcomes and survival显示文摘 | Timothy J.S. Cross Charalambos G. Antoniades Paolo Muiesan Thawab Al‐Chalabi Varuna Aluvihare Kosh Agarwal Bernard C. Portmann Mohammed Rela Nigel D. Heaton John G. O’Grady Michael A. Heneghan | 2007 | Liver Transpl2007，，10： | 1 |
| 11 | On feeding of Amur stur-geon Acipenser schrenckii in the estuary part of the Amur River显示文摘 | Kolobov V Y and Koshe!ev V N | 2014 | Journal of Ichthyology2014，54，7： | 1 |
| 12 | Characterization of the NADPH-dependent metabolism of 17β-estradiol to muhiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5显示文摘 | LEE AJ KOSH JW CONNEY AH et O1 | 2001 | J Pharmacol Exp Ther2001，298，2： | 1 |
| 13 | Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5 显示文摘 | Lee A Kosh J Conney A | 2001 | JPharmacolExp Ther2001，298，2： | 1 |
| 14 | Effect of hyperparathyroidism on arterial distensibility in renal transplant recipionts显示文摘 | Barenbrock M Hausberg M Kosh M st al | 1998 | Kidney Int1998，54，1： | 1 |
| 15 | Small-dose fenta nyl: optimal time of injection for blunting the circula- tory responses to tracheal intubation 显示文摘 | KoSH Han Yj | 1998 | Anesth Analg1998，86，3： | 1 |
| 16 | Reduced arterial distensibility is a predictor of cardiovascular disease in patients after renal transplantation显示文摘 | Barenbrock M Kosh M Joster E | | 0，，01： | 1 |
| 17 | Telaprevir Twice Daily is Noninferior to Telaprevir Every 8 hrs for Patients with Chronic Hepatitis C显示文摘 | Maria Buti Kosh Agarwal Yves Horsmans William Sievert Ewa Janczewska Stefan Zeuzem Lisa Nyberg Robert S. Brown Christophe Hezode Mario Rizzetto Raymundo Parana Sandra De Meyer Ralph De Masi Donghan Luo Kirk Bertelsen James Witek | 2013 | Gastroenterology2013，，： | 1 |
| 18 | Increasing burden of liver disease in patients with HIV infection显示文摘 | Deepak Joshi John O’Grady Doug Dieterich Brian Gazzard Kosh Agarwal | 2011 | 2011 (9772)2011，，9772： | 1 |
| 19 | The impact of inflammatory bowel disease post‐liver transplantation for primary sclerosing cholangitis显示文摘 | Deepak Joshi Ingvar Bjarnason Ajay Belgaumkar John O’Grady Abid Suddle Michael A. Heneghan Varuna Aluvihare Mohammed Rela Nigel Heaton Kosh Agarwal | 2011 | Liver Int2011，，1： | 1 |
| 20 | British HIV A ssociation guidelines for the management of hepatitis viruses in adults infected with HIV 2013显示文摘 | Ed Wilkins Mark Nelson Kosh Agarwal Dola Awoyemi Eleanor Barnes Sanjay Bhagani Gary Brook Ashley Brown Sheena Castelino Graham Cooke Martin Fisher Anna Maria Geretti Robert James Ranjababu Kulasegaram Clifford Leen David Mutimer Chloe Orkin Emma Page Adri | 2013 | HIV Med2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员