|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 外用辣椒素治疗慢性疼痛:系统性综述显示文摘评价局部应用辣椒素治疗神经及肌肉骨骼功能失调引起的慢性疼痛的疗效和安全性。 | Lorna Mason R Andrew Moore Sheena Derry Jayne E Edwards Henry J Mcquay 孙静 | 2004 | 英国医学杂志中文版2004，7，5： | 3 |
| 2 | Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation. | Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 3 | Characterization of colonic dendritic cells in normal and colitic mice显示文摘AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC.METHODS: Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient (IL2-/-) mice that develop colitis.RESULTS: In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type 1 myeloid (CD11c+, CD11b+,B220-, CD8α-) DC made up the largest (40-45%) population and all DC expressed low levels of CD80, CD86, and CD40,and had high endocytic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes (MLN).The majority (>85%) of DC in the colon and MLN of IL2-/-mice were type 1 myeloid, and expressed high levels of MHC class Ⅱ, CD80, CD86, CD 40, DEC 205, and CCR5molecules and were of low endocytic activity consistent with mature DC.CONCLUSION: These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon. | Sheena M Cruickshank Nicholas R English Peter J Felsburg Simon R Carding | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 4 | Rates and impact of hepatitis on human immunodeficiency virus infection in a large African cohort显示文摘AIM:To determine the rates and impact of hepatitis B virus(HBV) and hepatitis C virus(HCV) infections on response to long-term highly active antiretroviral therapy(HAART) in a large human immunodeficiency virus(HIV) population in Nigeria.METHODS:HBV and HCV as well as HIV infections are endemic in sub Saharan Africa.This was a retrospective cohort study of 19 408 adults who were recruited between June 2004 and December 2010 in the AIDS Prevention Initiative in Nigeria in Nigeria programme at Jos University Teaching Hospital.Serological assays,including HBV surface antigen(HBsAg) and hepatitis C antibody were used to categorise hepatitis status of the patients.HBsAg was determined using enzyme immunoassay(EIA)(Monolisa HBsAg Ultra3;Bio-Rad).HCV antibody was tested using third generation EIA(DIA.PRO Diagnostic,Bioprobes srl,Milan,Italy).HIV RNA levels were measured using Roche COBAS Amplicor HIV-1 monitor test version 1.5(Roche Diagnostics,GmbH,Mannheim,Germany) with a detection limit of 400 copies/mL.Flow cytometry was used to determine CD4+ cell count(Partec,GmbH Munster,Germany).Comparison of categorical and continuous variables were achieved using Pearson's χ 2 and Kruskal Wallis tests respectively,on MedCalc for Windows,version 9.5.0.0(MedCalc Software,Mariakerke,Belgium).RESULTS:With an overall hepatitis screening rate of over 90% for each virus;HBV,HCV and HBV/HCV were detected in 3162(17.8%),1983(11.3%) and 453(2.5%) HIV infected adults respectively.The rate of liver disease was low,but highest among HIV monoinfected patients(29,0.11%),followed by HBV coinfected patients(15,0.08%).Patients with HBV coinfection and triple infection had higher log 10 HIV RNA loads(HBV:4.6 copies/mL vs HIV only:4.5 copies/mL,P<0.0001) and more severe immune suppression(HBV:645,55.4%;HBV/HCV:97,56.7%) prior to initiation of HAART compared to HIV mono-infected patients(1852,48.6%)(P<0.0001).Of 3025 patients who were 4.4 years on HAART and whose CD4 cell counts results at baseline and end of follow up were available for analyses,CD4 increase was significantly lower in those with HBV co-infection(HBV:144 cells/mm3 ;HBV/HCV:105 cells/mm3) than in those with HCV co-infection(165 cells/mm3) and HIV mono-infection(150 cells/mm3)(P=0.0008).CONCLUSION:High rates of HBV and HCV infections were found in this HIV cohort.CD4 recovery was significantly diminished in patients with HBV co-infection. | Nimzing Gwamzhi Ladep Patricia Aladi Agaba Oche Agbaji Auwal Muazu Placid Ugoagwu Godwin Imade Graham Cooke Sheena McCormack Simon David Taylor-Robinson John Idoko Phyllis Kanki | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 5 | Heterogeneity across the murine small and large intestine显示文摘The small and large intestine of the gastrointestinal tract(GIT) have evolved to have discrete functions with distinct anatomies and immune cell composition.The importance of these differences is underlined when considering that different pathogens have uniquely adapted to live in each region of the gut.Furthermore,different regions of the GIT are also associated with differences in susceptibility to diseases such as cancer and chronic inflammation.The large and small intestine,given their anatomical and functional differences,should be seen as two separate immunological sites.However,this distinction is often ignored with findings from one area of the GIT being inappropriately extrapolated to the other.Focussing largely on the murine small and large intestine,this review addresses the literature relating to the immunology and biology of the two sites,drawing comparisons between them and clarifying similarities and differences.We also highlight the gaps in our understanding and where further research is needed. | Rowann Bowcutt Ruth Forman Maria Glymenaki Simon Richard Carding Kathryn Jane Else Sheena Margaret Cruickshank | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 6 | Methods and designs-Survey of eye movement recording methods显示文摘 | Young L Sheena D | 1975 | Behavioral Research Methods and Instructions1975，7，5： | 1 |
| 7 | Comparison of the effects of two methods of cryopresevation on testicular sperm DNA显示文摘 | E Kristine Steele Neil Mcclure Sheena E | 2000 | Fertil Steril2000，74，： | 1 |
| 8 | The effectiveness of compression garments and lower limb exercise on post-exer- cise blood pressure regulation in orthostatically intolerant Ath- letes显示文摘 | Sheena EP Keith PG Gregory PW | 2010 | Clin J Sport Med2010，20，： | 1 |
| 9 | 18 F-4V for PET–CT Imaging of VCAM-1 Expression in Atherosclerosis显示文摘 | Matthias Nahrendorf Edmund Keliher Peter Panizzi Hanwen Zhang Sheena Hembrador Jose-Luiz Figueiredo Elena Aikawa Kimberly Kelly Peter Libby Ralph Weissleder | 2009 | JACC: Cardiovascular Imaging2009，，10： | 1 |
| 10 | Effects of weaning age on the behavioural and neuroendocrinedevelopment of piglets 显示文摘 | Susan J Christine M Sheena K R | 2008 | Appl Ani Behav Sei2008，110，1： | 1 |
| 11 | Assessing impact of climate change on forest cover type shifts in Western Himalayan Eco-region显示文摘Climate is a critical factor affecting forest ecosystems and their capacity to produce goods and services. Effects of climate change on forests depend on ecosystem-specific factors including dimensions of climate (temperature, precipitation, drought, wind etc.). Available information is not sufficient to support a quantitative assessment of the ecological, social and economic consequences. The present study assessed shifts in forest cover types of Western Himalayan Eco-region (700?4500 m). 100 randomly selected samples (75 for training and 25 for testing the model), genetic algorithm of rule set parameters and climatic envelopes were used to assess the distribution of five prominent forest cover types (Temperate evergreen, Tropical semi-evergreen, Temperate conifer, Subtropical conifer, and Tropical moist deciduous forests). Modelling was conducted for four different scenarios, current scenario, changed precipitation (8% increase), changed temperature (1.07°C increase), and both changed temperature and precipitation. On increasing precipitation a downward shift in the temperate evergreen and tropical semi-evergreen was observed, while sub-tropical conifer and tropical moist-deciduous forests showed a slight upward shift and temperate conifer showed no shift. On increasing temperature, an upward shift in all forest types was observed except sub-tropical conifer forests without significant changes. When both temperature and precipitation were changed, the actual distribution was maintained and slight upward shift was observed in all the forest types except sub-tropical conifer. It is important to understand the likely impacts of the projected climate change on the forest ecosystems, so that better management and conservation strategies can be adopted for the biodiversity and forest dependent community. Knowledge of impact mechanisms also enables identification and mitigation of some of the conditions that increase vulnerability to climate change in the forest sector. | P.K.Joshi Asha Rawat Sheena Narula Vinay Sinha | 2012 | Journal of Forestry Research2012，23，1： | 1 |
| 12 | Nutritional properties of bamboo shoots: potential and prospects for utilization as a health food 显示文摘 | Nirmala C Madho S B Sheena H | 2011 | Comprehensive Reviews in Food Science and Food Safety2011，10，3： | 1 |
| 13 | Validation and Implementation of Targeted Capture and Sequencing for the Detection of Actionable Mutation, Copy Number Variation, and Gene Rearrangement in Clinical Cancer Specimens显示文摘 | Colin C. Pritchard Stephen J. Salipante Karen Koehler Christina Smith Sheena Scroggins Brent Wood David Wu Ming K. Lee Suzanne Dintzis Andrew Adey Yajuan Liu Keith D. Eaton Renato Martins Kari Stricker Kim A. Margolin Noah Hoffman Jane E. Churpek Jonathan | 2014 | The Journal of Molecular Diagnostics2014，，1： | 1 |
| 14 | Gender-blind marketing:businesswomen' s perceptions of airline services 显示文摘 | Sheena W Pritchard A Morgan N J | 2000 | Tourism Management2000，，21： | 1 |
| 15 | Specifying Model Transformations at the Metamodel Level显示文摘 | Sheena R Judson Robert B France Doris L Carver | 2003 | Proc of the Workshop in Software Model Engineering2003，，： | 1 |
| 16 | Survey of eye movement record- ing methods 显示文摘 | YOUNG L R SHEENA D | 1975 | Behavior Research Methods and Instru- mentation1975，7，5： | 1 |
| 17 | Incidence of epidural hematoma, infection, and neurologic injury in obstetric patients with epiduml analgesia/anesthesia显示文摘 | Wilhelm R Sheena D Henry MQ | 2006 | Anesthesiology2006，105，2： | 1 |
| 18 | The objective rating of oral-motor functions during feeding 显示文摘 | Sheena R David S | 1995 | Dysphagia1995，10，： | 1 |
| 19 | Oral feeding in low birth weight infants显示文摘 | Lau C Sheena HR shulman RJ | 1997 | The Journal of Pediatrics1997，130，4： | 1 |
| 20 | Strategic fn- resight fi)r (coastal) urban tourism market complexity: The case of Bournemouth显示文摘 | Sheena Carlisle Aleksander Johansen Martin Kunc | 2016 | Coastal Management2016，，54： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员