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| 1 | Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma显示文摘Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management.Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1(complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis. | Ruchi Sharma Abid Suddle Alberto Quaglia Praveen Peddu John Karani Thomas Satyadas | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，5： | 7 |
| 2 | Developing a donation after cardiac death risk index for adult and pediatric liver transplantation显示文摘AIM To identify objective predictive factors for donor after cardiac death(DCD) graft loss and using those factors, develop a donor recipient stratification risk predictive model that could be used to calculate a DCD risk index(DCD-RI) to help in prospective decision making on organ use.METHODS The model included objective data from a single institute DCD database(2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added to the model via forward selection, significance level P = 0.3. The warm ischemic threshold was clinically set at 30 min. Points were given to each predictor in proportion to their hazard ratio. Using this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk and respective graft survival calculated.RESULTS DCD graft survival predictors were primary indication for transplant(P = 0.066), retransplantation(P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) and donor hepatectomy time > 60 min(P = 0.028).According to the calculated DCD-RI score three risk classes could be defined of low(DCD-RI < 1), standard(DCD-RI 2-4) and high risk(DCD-RI > 5) with a 5 years graft survival of 86%, 78% and 34%, respectively.CONCLUSION The DCD-RI score independently predicted graft loss(P < 0.001) and the DCD-RI class predicted graft survival(P < 0.001). | Shirin Elizabeth Khorsandi Emmanouil Giorgakis Hector Vilca-Melendez John O'Grady Michael Heneghan Varuna Aluvihare Abid Suddle Kosh Agarwal Krishna Menon Andreas Prachalias Parthi Srinivasan Mohamed Rela Wayel Jassem Nigel Heaton | 2017 | World Journal of Transplantation2017，7，3： | 3 |
| 3 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 4 | Systematic re- view: the role of liver transplantation in the management of hepatocellular carcinoma显示文摘 | Maggs JRL Suddle AR Aluvihare V | 2012 | Aliment Pharmacol Ther2012，35，10： | 1 |
| 5 | Structural measures for a safer transport of hazardous materials by rail:The case of the basic network in The Netherlands显示文摘 | VAN DER VLIES A V SUDDLE S I | 2008 | Safety Science2008，46，1： | 1 |
| 6 | The risk management of third parties during construction in multifunctional urban locations显示文摘 | Suddle S | 2009 | Risk Analysis2009，29，7： | 1 |
| 7 | The impact of new firm formation on regional development in the Netherlands显示文摘 | van Stel A and Suddle K | 2008 | Small Business Economics2008，30，1： | 1 |
| 8 | The third spatial dimension risk approach for individual risk and group risk in multiple use of space显示文摘 | Shahid Suddle Ben Ale | 2005 | Journal of Hazardous Materials2005，123，： | 1 |
| 9 | The third spatial dimension risk approach for individual risk and group risk in multiple use of space 显示文摘 | SUDDLE S ALEIN B | 2005 | Journal of Hazardous Materials2005，123，： | 1 |
| 10 | The impact of new firm formation on regional development in the Netherlands 显示文摘 | Suddle K | 2008 | Small Business Eco- nomics2008，30，1： | 1 |
| 11 | How does en- trepreneurial activity affect the supply of informal in- vestors? 显示文摘 | Burke A Hartog C van Stel A Suddle K | 2010 | Venture Capital : An International Journal of Entrepreneurial Finance2010，12，1： | 1 |
| 12 | Emerging strategies in the treatment of advanced hepatocellular carcinoma: the role of targeted therapies 显示文摘 | Lord R Suddle A Ross P J | 2011 | International Journal of Clinical Practice2011，65，2： | 1 |
| 13 | The impact of inflammatory bowel disease post‐liver transplantation for primary sclerosing cholangitis显示文摘 | Deepak Joshi Ingvar Bjarnason Ajay Belgaumkar John O’Grady Abid Suddle Michael A. Heneghan Varuna Aluvihare Mohammed Rela Nigel Heaton Kosh Agarwal | 2011 | Liver Int2011，，1： | 1 |
| 14 | 显示文摘 | Tang P L Suddle E D | 1991 | J Polym Sci1991，43，： | 1 |
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