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| 1 | Understanding the development and function of T follicular helper cells显示文摘A fundamental function of T helper(Th)cells is to regulate B-cell proliferation and immunoglobulin class switching,especially in the germinal centers.Th1 and Th2 lineages of CD41 T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a(IgG2a)and IgG1/IgE,respectively.Recently,it has become clear that a subset CD41 T cells,named T follicular helper(Tfh)cells,is critical to B-cell response induction.In this review,we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation,the relationship of Tfh cells to other CD41 T-cell lineages,and the role of Tfh cells in health and disease. | Roza I Nurieva Yeonseok Chung | 2010 | Cellular & Molecular Immunology2010，7，3： | 18 |
| 2 | Autophagy and neurodegenerative disorders显示文摘Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders. | Evangelia Kesidou Roza Lagoudaki Olga Touloumi Kyriaki-Nefeli Poulatsidou Constantina Simeonidou | 2013 | Neural Regeneration Research2013，8，24： | 15 |
| 3 | 中俄石油合作态势研究显示文摘目前,中俄石油合作发展到了一个新的阶段,中俄石油管道已投入使用,贷款换石油项目促进了原油贸易稳步增长,石油上下游领域合作进展较快。但是,一些来自俄罗斯、中国、国际的制约因素也凸现出来。因此,深化中俄'战略协作伙伴关系',增强双方政治互信,把握俄罗斯能源战略,制定自身能源发展战略,加强价格机制方面的合作,中国加大资金支持力度,鼓励民营企业参与等对策成为推动中俄石油合作的有力保障。 | GORA ROZA 刘俏 | 2013 | 经济研究导刊2013，，11： | 6 |
| 4 | Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis显示文摘BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear indications.There are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic patients.Furthermore,PPI users and PPI exposure in some studies have been poorly defined with many confounding factors.AIM To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose exposure.METHODS Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to 2017.PPI users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic decompensation.Cox regression analysis for comparison was done after propensity score adjustment.Further risk of hepatic decompensation was analysed by Poisson regression.RESULTS Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were non-users.PPI users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P<0.001].CONCLUSION PPI use in decompensated cirrhosis is associated with increased risk of mortality and hepatic decompensation.Longer PPI exposure with cDDD>90 increases the risk of mortality. | Marianne Anastasia De Roza Lim Kai Jia Wen Kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang | 2019 | World Journal of Gastroenterology2019，25，33： | 6 |
| 5 | Characteristics of Trays Using Inertial Separation Technology显示文摘Though they look very different,UOP SimulFlowTM,Koch-Glitsch Ultra-FracTM,Jaeger CoFloTM and Shell ConSepTM trays fall into the same category of trays using inertial separation technology. However,flooding mechanisms and the trends of entrainment and efficiency are different due to their different working principles. This paper provides a detailed analysis of these trays using available information from literature and U.S. Patents. Efforts are also made to interpret the observations reported. In terms of tray efficiency,it is found that SimulFlow,Ultra-Frac and CoFlo trays are typical point efficiency devices due to a completely mixed liquid pool on the tray deck,while ConSep trays can take advantage of liquid concentration gradient on the tray deck,which makes this tray at-tractive among all ultra high capacity trays. | YANG Quan Giuseppe Mosca Mario Roza | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 4 |
| 6 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 7 | Eosinophilic cholangitis treatment with budesonide显示文摘Eosinophilic cholangitis is a rare cause of deranged obstructive liver function tests. It has been described as a great mimicker for malignant biliary strictures and bile duct obstruction. There are only case reports available on treatment experience for eosinophilic cholangitis. A large proportion of patients present with biliary strictures for which they have undergone surgery or endoscopic treatment and a small proportion was given systemic corticosteroid. We share our treatment experience using budesonide which has fewer systemic side effects to prednisolone and avoids invasive management. | Marianne Anastasia De Roza Chee Hooi Lim | 2017 | World Journal of Hepatology2017，9，36： | 2 |
| 8 | Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome:A prospective multi-centre cohort study显示文摘BACKGROUND Autoimmune markers including plasma cells(PC),anti-smooth-muscle antibody(ASMA),anti-nuclear antibody(ANA),and raised immunoglobulin G(IgG)are commonly observed in non-alcoholic steatohepatitis(NASH),however their clinical significance is unknown.AIM To determine if autoimmune markers in NASH patients are independently associated with poorer clinical outcomes.METHODS Consecutive patients with biopsy proven NASH from Christchurch Hospital,New Zealand and Singapore General Hospital(SGH)were included between 2005 to 2016 in a prospective multi-centre cohort study.Patients with other causes of chronic liver disease were excluded.IgG>14 g/L or globulin fraction>50%,ANA≥1:40,SMA≥1:40 were considered positive.Multivariate analysis was performed to assess which markers were independently associated with mortality and hepatic decompensation.RESULTS Total 261 patients were included of which 201 were from SGH.The median age was 53 and 51.9%were male.Advanced fibrosis was present in 31.4%at diagnosis.PC,ASMA,ANA and raised IgG were observed in 13.1%,4.9%,27.8%and 30.1%of patients respectively.After multivariate analysis,elevated IgG[Hazard Ratio(HR)6.79,95%CI:2.93-17.15]and fibrosis stage(HR 1.37,95%CI:1.03-1.87)were found to be independently associated with increased risk of liver decompensation.Age(HR 1.06,95%CI:1.02-1.10)and elevated IgG(HR 3.79,95%CI:1.90-7.68)were independent factors associated with higher mortality risk.CONCLUSION Elevated IgG,rather than ANA,ASMA or plasma cells,is independently associated with increased risk of hepatic decompensation and mortality in NASH.It could hence be important for prognostication. | Marianne Anastasia De Roza Mehul Lamba George Boon-Bee Goh Johnathan Huey-Ming Lum Mark Chang-Chuen Cheah Jing Hieng Jeffrey Ngu | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 9 | Direct observation of photonic Landau levels and helical edge states in strained honeycomb lattices显示文摘We report the realization of a synthetic magnetic field for photons and polaritons in a honeycomb lattice of coupled semiconductor micropillars.A strong synthetic field is induced in both the s and p orbital bands by engineering a uniaxial hopping gradient in the lattice,giving rise to the formation of Landau levels at the Dirac points.We provide direct evidence of the sublattice symmetry breaking of the lowest-order Landau level wavefunction,a distinctive feature of synthetic magnetic fields.Our realization implements helical edge states in the gap between n=0 and n=±1 Landau levels,experimentally demonstrating a novel way of engineering propagating edge states in photonic lattices.In light of recent advances in the enhancement of polariton–polariton nonlinearities,the Landau levels reported here are promising for the study of the interplay between pseudomagnetism and interactions in a photonic system. | Omar Jamadi Elena Rozas Grazia Salerno Marijana Milicevic Tomoki Ozawa Isabelle Sagnes Aristide Lemaitre Luc Le Gratiet Abdelmounaim Harouri Iacopo Carusotto Jacqueline Bloch Alberto Amo | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 10 | Interaction of anions with perfluoro aromatic compounds 显示文摘 | Alkorta I Rozas I Elguero J | 2002 | J Am Chem Soc2002，124，29： | 1 |
| 11 | v5:a software for comprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J Dna S P | 2009 | Bioinformatics2009，25，： | 1 |
| 12 | DnaSP,DNA polymorphism analyses by the coalescent and other methods显示文摘 | Rozas J Sanchez-DelBarrio J C Messeguer X | 2003 | Bioinformatics2003，19，18： | 1 |
| 13 | DnaSP v5: A software for eomprehensive analysis of DNA polymorphism data显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 14 | DNA polymorphism analyses by the coalescent and oth- er methods 显示文摘 | ROZAS J SANCHEZ-DELBARRIO J C MESSEGRER X | 2003 | Bioinformaics2003，19，： | 1 |
| 15 | Regeneration patterns, dendroecology, and forest-use history in an old-growth beech-oak lowland forest in Northern Spain显示文摘 | Rozas V | 2003 | Forest Ecology and Management2003，，： | 1 |
| 16 | Dnasp, DNA polymorphism analyses by the coalescent and other methods 显示文摘 | Rozas J Sanchez-DelBarrio J C Messeguer X | 2003 | Bioinformatics2003，19，18： | 1 |
| 17 | Monitoring ultraviolet-B-induced DNA damage in individual diatom cels by immunofluorescent thymine dimmer detection显示文摘 | Buma A G J Van Hannen E J Roza L | 1995 | Journal of Phycology1995，51，： | 1 |
| 18 | DnaSP, DNA polymorphism analyses by the coalescent and other methods显示文摘 | Rozas J Sanchez-DelBarrio J C Messeguer X | 2003 | Bioinformatics2003，19，18： | 1 |
| 19 | Dna S P v5: A software for comprehensive analysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，11： | 1 |
| 20 | DnaSP v5 : A software for comprehensive anal- ysis of DNA polymorphism data 显示文摘 | Librado P Rozas J | 2009 | Bioinformatics2009，25，： | 1 |
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