|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 2 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 3 | Granulocyte colony-stimulating fac- tor: molecular mechanisms of action during steady state and ' emer- gency'hematopoiesis 显示文摘 | Panopoulos AD Watowich SS | 2008 | Cytokine2008，42，3： | 1 |
| 4 | Biophysical characterization of hepatitis C virus core protein :implications for interactions within the virus and host显示文摘 | Kunkel M Watowich SJ | 2004 | FEBS Lett2004，557，13： | 1 |
| 5 | The erythro-poietin receptor: its role in hernatopoiesis and myeloproliferative diseases显示文摘 | Longmore G D Watowich S S Hilton D J | 1993 | J CellBiol1993，123，： | 1 |
| 6 | Hark back: passive immunotherapy for influenza and other serious infections 显示文摘 | Luke TC Casadevall A Watowich S J | 2010 | Crit Care Med2010，38，： | 1 |
| 7 | Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells显示文摘 | Wang L Arcasoy MO Watowich SS | | 0，，03： | 1 |
| 8 | HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate caxcinomas 显示文摘 | Gray MJ Zhang J Ellis LM Semenza GL Evans DB Watowich SS | 2005 | Oncogene2005，24，19： | 1 |
| 9 | Optimal paths for thermodynamic systems:the ideal diesel cycle显示文摘 | Hoffman K H Watowich J S Berry R S | 1985 | J Appl Phys1985，58，2： | 1 |
| 10 | Structural and kinetic determinants of aldehyde reduction by aldose reductase显示文摘 | Srivastava S Watowich S J Petrash J M | 1999 | Biochemistry1999，38，1： | 1 |
| 11 | The erythropoietin receptor: its role in hematopoiesis and myeloproliferative diseases 显示文摘 | Longmore G D Watowich S S Hilton D J | 1993 | J CellBiol1993，123，： | 1 |
| 12 | Granulocyte colony-stimulating factor:Molecular mechanisms of action during steady state and 'emergency' hematopoiesis显示文摘 | Panopoulos HD Watowich SS | 2008 | Cytokine2008，42，： | 1 |
| 13 | Granulocyte colony-stimulating factor:molecular mechanisms of action during steady state and emergency hematopoiesis显示文摘 | Panopoulos AD Watowich SS | 2008 | Cytokine2008，42，3： | 1 |
| 14 | A status report on DC development 显示文摘 | Li H S Watowich S S | 2012 | J Leukocyte Biology2012，92，3： | 1 |
| 15 | Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and ' emergency' hematopoiesis 显示文摘 | Panopoulos AD Watowich SS | 2008 | Cytokine2008，42，3： | 1 |
| 16 | The erythropoietin receptor: molecular structure and hematopoietic signaling pathways 显示文摘 | WATOWICH SS | 2011 | J In- vestig Med2011，59，7： | 1 |
| 17 | The erythropoietin receptor: molecular structure and hematopoietic signaling pathways显示文摘 | Watowich SS | 2011 | J Investig Med2011，59，7： | 1 |
| 18 | Combinatorial selection of a RNA thioaptamer that binds to Venezuelan equine encephalitis virus capsid protein显示文摘 | Kang J Lee MS Watowich SJ | 2007 | FEBS Lett2007，581，13： | 1 |
| 19 | Biophysical characterization and vector-speciifc antagonist activity of domain Ⅲ of the tick-borne flavivirus envelope protein显示文摘 | Bhardwaj S Holbrook M Shope RE Barrett ADT Watowich SJ | | 0，，： | 1 |
| 20 | Combinatorial selection of a RNA thioaptamer that binds to Venezuelan equine encephalitis virus capsid protein显示文摘 | Kang J Lee MS Watowich SJ | 2007 | FEBS Lett2007，581，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员