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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel显示文摘 | Panayiotis P. Constantinides Karel J. Lambert Alex K. Tustian Brian Schneider Salima Lalji Wenwen Ma Bryan Wentzel Dean Kessler Dilip Worah Steven C. Quay | 2000 | Pharmaceutical Research2000，，2： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Multislice CT imaging ofpulmonary embolism显示文摘 | Schoepf UJ Kessler MA Rieger CT | 2001 | European Radiology2001，11，11： | 1 |
| 5 | Crystal structure of DhbE,an archetype for aryl acid activating domains of modular nonriboso-mal peptide synthetases 显示文摘 | May JJ Kessler N Marahiel MA | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 6 | The effectof bivalirudin on costs and outcomes of treatment ofST-segment elevation myocardial infarction显示文摘 | Kessler DP Kroch E Hlatky MA | 2011 | AmHeart J2011，162，3： | 1 |
| 7 | Devemopment of a3-dimerasional method to detenmine the tibial stope with multialice CT显示文摘 | Kessler MA Hurkart A Martinck V | | 0，，02： | 1 |
| 8 | Multislice CT imaging of pulmonaryembolism 显示文摘 | Schoepf UJ Kessler MA Rieger CT | 2001 | Eur Radiol2001，11，： | 1 |
| 9 | Function,osteoarthritis and activity after ACL-rupture:11 years follow-up results of conservative versus reconstructive treatment显示文摘 | Kessler MA Behrend H Henz S | 2008 | Knee Surg Sport Traumatol Arthrosc2008，16，5： | 1 |
| 10 | Regulation of interleukin (IL)-1a,IL-1b and IL-6 expression by growth hormone and prolactin in bovine thymic stromal cells显示文摘 | Tseng YH Kessler MA Schuler LA | 1997 | Mol Cell Endocrinol1997，128，12： | 1 |
| 11 | Development of a 3-dimensional method to determine the tibial slope with multislice CT显示文摘 | Kessler MA Burkart A Martinek V | 2003 | Z Orthop Ihre Grenzgeb2003，141，： | 1 |
| 12 | Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients显示文摘 | Kessler HA Eron JJ | 2005 | AIDS2005，19，15： | 1 |
| 13 | Development of a 3-dimensional method to determine the tibial slope with multislice CT显示文摘 | Kessler MA Burkart A Mart inek V | 2003 | Z Orthop Ihre Grenzgeb2003，，3： | 1 |
| 14 | Tunnel placement in anterior cruciate ligament(ACL) reconstruction: quality control in a teaching hospital显示文摘 | Behrend H Stutz G Kessler MA | 2006 | Knee Surg Sports Traumatol Arthrosc2006，11，： | 1 |
| 15 | Tunnel placement in anterior cruciate ligament(ACL)reconstruction:Quality control in a teaching hospital显示文摘 | Behrend H Stutz G Kessler MA | | 0，，11： | 1 |
| 16 | Tunnel placement in anterior cruciate ligament (ACL) reconstruction : quality control in a teaching hospital 显示文摘 | Behrend H Stutz G Kessler MA | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，11： | 1 |
| 17 | Tunnel placement in anterior cruciate ligament(ACL)reconstruction:Quality control in a teaching hospital显示文摘 | Behrend H Stutz G Kessler MA | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，11： | 1 |
| 18 | Heparin-grafted dialysis membrane al ows minimal systemic anticoagulation in regular hemodialysis patients:a prospective proof-of-concept study显示文摘 | Kessler M Gangemi C Gutierrez MA | | 0，，： | 1 |
| 19 | Function, osteoarthri- tis and activity after ACL-rupture: 11 years follow-up results of conservative versus reconstructive treatment 显示文摘 | Kessler MA Behrend H Henz S | 2008 | Knee Surg Sports Traumatol Arthrosc2008，16，5： | 1 |
| 20 | Diagnosis of lung embolism with multislice spiral CT 显示文摘 | Schoepf UJ Kessler MA Rieger C | 2001 | Radiologe2001，41，3： | 1 |
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