|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012,,2: | 7 |
| 2 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016,8,10: | 5 |
| 3 | Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass显示文摘 | George Asimakopoulos Peter L.C Smith Chandana P Ratnatunga Kenneth M Taylor | 1999 | The Annals of Thoracic Surgery1999,,3: | 2 |
| 4 | Mercury Levels in Mink (Mustela vison) and River Otter (Lontra canadensis) from Northeastern North America显示文摘 | David E. Yates David T. Mayack Kenneth Munney David C. Evers Andrew Major Taranjit Kaur Robert J. Taylor | 2005 | Ecotoxicology (-)2005,,1: | 1 |
| 5 | One Thousand Consecutive Pancreaticoduodenectomies显示文摘 | John L. Cameron Taylor S. Riall JoAnn Coleman Kenneth A. Belcher | 2006 | Annals of Surgery2006,,1: | 1 |
| 6 | ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Sur显示文摘 | Alan T. Hirsch Ziv J. Haskal Norman R. Hertzer Curtis W. Bakal Mark A. Creager Jonathan L. Halperin Loren F. Hiratzka William R.C. Murphy Jeffrey W. Olin Jules B. Puschett Kenneth A. Rosenfield David Sacks James C. Stanley Lloyd M. Taylor Christopher J. W | 2006 | Circulation2006,,11: | 1 |
| 7 | A component and message-based architectural style for GUI software显示文摘 | Taylor Richard N Medvidovic Nenad Anderson Kenneth M | 1996 | IEEE Transactions on Software Engineering1996,22,8: | 1 |
| 8 | WACS-Wide-area stability and voltage control system: R and D and online demonstration 显示文摘 | Taylor Carson W Erickson Dennis C Martin Kenneth E | 2005 | Proceedings of the IEEE2005,93,5: | 1 |
| 9 | HIV Coinfection With Hepatitis C Virus: Evolving Epidemiology and Treatment Paradigms显示文摘 | Lynn E. Taylor Tracy Swan Kenneth H. Mayer | 2012 | Clinical Infectious Diseases (suppl )2012,,1: | 1 |
| 10 | The attention–intention–effort pathway in the development of psychophysiologic insomnia: A theoretical review显示文摘 | Colin A. Espie Niall M. Broomfield Kenneth M.A. MacMahon Lauren M. Macphee Lynne M. Taylor | 2006 | Sleep Medicine Reviews2006,,: | 1 |
| 11 | International air transportation and economic development 显示文摘 | Kenneth Button Samantha Taylor | 2000 | Journal of Air Transport Management2000,6,4: | 1 |
| 12 | Us Army Employment of Unattended Ground Sen- sors 显示文摘 | Kenneth Elgort Scott Komaromy John Madden Andmv Taylor | 2005 | Proceeding of 2005 System and Information Engi- neering Design Symposium2005,10,: | 1 |
| 13 | A component and message-based architectural style for GUI software显示文摘 | Richard N Taylor Nenad Medvidovic Kenneth M Anderson | 1996 | IEEE Transactions on Software Engineering1996,22,6: | 1 |
| 14 | Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett’s esophagus: international, partially blinded, randomized phase III trial <ce:link locator='fx1'/>显示文摘 | Bergein F. Overholt Charles J. Lightdale Kenneth K. Wang Marcia I. Canto Steven Burdick Roger C. Haggitt Mary P. Bronner Shari L. Taylor Michael G.A. Grace Michelle Depot | 2005 | Gastrointestinal Endoscopy2005,,4: | 1 |
| 15 | 15-Lipoxygenase Catalytically Consumes Nitric Oxide and Impairs Activation of Guanylate Cyelase显示文摘 | Valerie B O'Donnell Kenneth B Taylor Sampath Parthasarathy | 1999 | J Biol Chem1999,274,20: | 1 |
| 16 | The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster显示文摘 | Stephanie M. Fullerton Anne V. Buchanan Vibhor A. Sonpar Scott L. Taylor Joshua D. Smith Christopher S. Carlson Veikko Salomaa Jari H. Steng?rd Eric Boerwinkle Andrew G. Clark Deborah A. Nickerson Kenneth M. Weiss | 2004 | Human Genetics2004,,1: | 1 |
| 17 | International Air Transportation and Economic Development 显示文摘 | Kenneth Button Samantha Taylor | 2000 | Journal of Air Transport Manage- ment2000,6,4: | 1 |
| 18 | Internet robots: a new robotics niche显示文摘 | Kenneth Taylor Barney Dalton | 2000 | In IEEE Robotics & Automation Magazine2000,,3: | 1 |
| 19 | Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: Results of a randomized phase II trial显示文摘 | R. Phillip Dellinger Janice L. Zimmerman Robert W. Taylor Richard C. Straube David L. Hauser Gerard J. Criner Kenneth Davis Thomas M. Hyers Peter Papadakos | 1998 | Critical Care Medicine1998,,1: | 1 |
| 20 | International air transportation and economic development显示文摘 | Kenneth Button Samantha Taylor | 2000 | Journal of Air Transport Management2000,,6: | 1 |