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| 1 | Role of sex steroid receptors in pathobiology of hepatocellular carcinoma显示文摘The striking gender disparity observed in the incidence of hepatocellular carcinoma (HCC) suggests an important role of sex hormones in HCC pathogenesis. Though the studies began as early as in 1980s,the precise role of sex hormones and the significance of their receptors in HCC still remain poorly understood and perhaps contribute to current controversies about the potential use of hormonal therapy in HCC. A comprehensive review of the existing literature revealed several shortcomings associated with the studies on estrogen receptor (ER) and androgen receptor (AR) in normal liver and HCC. These shortcomings include the use of less sensitive receptor ligand binding assays and immunohistochemistry studies for ERα alone until 1996 when ERβ isoform was identified. The animal models of HCC utilized for studies were primarily based on chemical-induced hepatocarcinogenesis with less similarity to virus-induced HCC pathogenesis. However,recent in vitro studies in hepatoma cells provide newer insights for hormonal regulation of key cellular processes including interaction of ER and AR with viral proteins. In light of the above facts,there is an urgent need for a detailed investigation of sex hormones and their receptors in normal liver and HCC. In this review,we systematically present the information currently available on androgens,estrogens and their receptors in normal liver and HCC obtained from in vitro,in vivo experimental models and clinical studies. This information will direct future basic and clinical research to bridge the gap in knowledge to explore the therapeutic potential of hormonal therapy in HCC. | Mamta Kalra Jary Mayes Senait Assefa Anil K Kaul Rashmi Kaul | 2008 | World Journal of Gastroenterology2008，14，39： | 18 |
| 2 | 对气候变暖响应下土壤CO_2释放的估计过高——老龄土壤有机质的分解具耐温性显示文摘本研究预测,相对于植被的净初级生产力(NPP)来说,随着全球变暖,有机质分解速度加快,土壤有机碳的贮藏速度将减少。因为土壤碳的含量是目前大气含量的两倍,而且从土壤中分解的碳要释放到大气中,因此,土壤碳贮量的减少会大量增加大气CO_2浓度。但是,土壤碳贮量减少的预测在很大程度上依赖于这样的隐含假设:所有土镶有机质的分解像新鲜凋落物的分解一样对温度较为敏感。我们测定了土壤碳的数量和年龄,以及沿温度梯度的凋落物的分解,并用一个简单的模型来描述土壤碳的动态,以显示老土壤有机质的分解阻抗温度的变化。因此,在对气候变暖的响应下,我们估算的分解速度的加快比从前预计的明显要低,并且预测北方森林土壤碳的贮量将增加。 | Jari Liski Annikki Mkel Carl Johan Westman 李叙勇 | 1999 | 人类环境杂志1999，28，2： | 16 |
| 3 | Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence显示文摘AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as 'front-positive' and in 41% as 'front-negative'. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the 'front-positive' tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. | Suvi Tuulia Avoranta Eija Annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm | 2012 | World Journal of Gastroenterology2012，18，33： | 9 |
| 4 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 5 | 地权结构和村庄民主对农户林业投入的影响显示文摘在民主实施集体林权改革的要求下,通过中国南方集体林区658户农户调研数据,运用两步法Double-Hurdle模型重点研究林地产权结构优化及村庄民主程序对农户林业投入的影响。研究发现林地使用权与处置权优化具有显著的投资激励效应,而林地使用权的投资激励效用不显著。更重要的是,村庄民主能够显著正向调节投资激励效应,主要是林地通过使用权与处置权发挥作用的。可能的解释为村庄民主程序能够显著增强农户对林地使用权与处置权的感知、认知与信心。基于研究结论,提出三个方面政策启示:(1)虽然新一轮改革具有一定的投资激励效应,但是法律与制度层面的林地产权制度并未完全落实,基层政府仍有进一步优化和推进改革配套政策有效落实的空间,尤其是要重视林农收益权的提升;(2)相关管理部门须进一步引导农户正确、充分地认知其对于自身林地资源享有的权利,增强农户对林地产权的认知与信心,以加强政策效能;(3)政府仍需推进村庄民主制度建设,加强农民在村庄公共事务决策中的话语权,运用村庄民主程序显化基层群众的政策需求,以辅助政府进行有效的政策供给。 | 任洋 Jari Kuuluvainen 姚顺波 薛彩霞 杨柳 | 2019 | 西北农林科技大学学报(社会科学版)2019，19，1： | 5 |
| 6 | Numerical and Experimental Modelling of Gas Flow and Heat Transfer in the Air Gap of an Electric Machine. Part II: Grooved Surfaces显示文摘The study deals with the cooling of a high-speed electric machine through an air gap with numerical and experimental methods. The rotation speed of the test machine is between 5000-4000 r/rain and the machine is cooled by a forced gas flow through the air gap. In the previous part of the research the friction coefficient was measured for smooth and grooved stator cases with a smooth rotor. The heat transfer coefficient was recently calculated by a numerical method and measured for a smooth stator-rotor combination. In this report the cases with axial groove slots at the stator and/or rotor surfaces are studied. Numerical flow simulations and measurements have been done for the test machine dimensions at a large velocity range. At constant mass flow rate the heat transfer coefficients by the numerical method attain bigger values with groove slots on the stator or rotor surfaces. The results by the numerical method have been confirmed with measurements. The RdF-sensor was glued to the stator and rotor surfaces to measure the heat flux through the surface, as well as the temperature. | Maunu KUOSA Petri SALLINEN Arttu REUNANEN Jari BACKMAN Jaakko LARJOLA Lasse KOSKELAINEN | 2005 | Journal of Thermal Science2005，14，1： | 4 |
| 7 | Fluid dynamic modeling of a free piston engine with labyrinth seals显示文摘Preliminary design and simulation of a free piston engine suitable for small-scale energy production in distributed energy systems is presented in this paper.The properties,particularly the properties of gas seals of the engine are simulated using a simulation program developed for this case,and the results are utilized in preliminary main design parameter selection.The engine simulation program was developed by combining and modifying the source codes of the simulation and calculation programs obtained from Helsinki University of Technology,Tampere University of Technology,and Lappeenranta University of Technology.Because of the contact-free labyrinth seal used in the piston,the efficiency of the motor is lower than the efficiency of a conventional motor with oil lubricated piston rings.On the other hand,the lack of bearing losses,and the lack of losses associated with a crankshaft system and a gearbox,as well as the lack of lubrication oil expenses,compensates this effect.As a net result,this new motor would perform slightly better than the conventional one.Being completely oil-free,it is very environmentally friendly,and its exhaust gases are completely free of oil residuals which are causing problems in normal gas motors. | Jaakko Larjola Juha Honkatukia Petri Sallinen Jari Backman | 2010 | Journal of Thermal Science2010，19，2： | 4 |
| 8 | Observation and modelling of snow and sea ice mass balance and its sensitivity to atmospheric forcing during spring and summer 2007 in the Central Arctic显示文摘Snow depth and sea ice thickness were observed applying an ice mass balance buoy(IMB)in the drifting ice station Tara during the International Polar Year in 2007.Detailed in situ observations on meteorological variables and surface fluxes were taken during May to August.For this study,the operational analyses and short-term forecasts from two numerical weather prediction(NWP)models(ECMWF and HIRLAM)were extracted for the Tara drift trajectory.We compared the IMB,meteorological and surface flux observations against the NWP products,also applying a one-dimensional thermodynamic sea ice model(HIGHTSI)to calculate the snow and ice mass balance and its sensitivity to atmospheric forcing.The modelled snow depth time series,controlled by NWP-based precipitation,was in line with the observed one.HIGHTSI reproduced well the snowmelt onset,the progress of the melt,and the first date of snow-free conditions.HIGHTSI performed well also in the late August freezing season.Challenges remain to model the“false bottom”observed during the melting season.The evolution of the vertical temperature profiles in snow and ice was better simulated when the model was forced by in situ observations instead of NWP results.During the melting period,the nonlinear ice temperature profile was successfully modelled with both forcing options.During spring and the melting season,total sea ice mass balance was most sensitive to uncertainties in NWP results for the downward longwave radiation,followed by the downward shortwave radiation,air temperature,and wind speed. | Bin CHENG Timo VIHMA Timo PALO Marcel NICOLAUS Sebastian GERLAND Laura RONTU Jari HAAPALA Donald PEROVICH | 2021 | Advances in Polar Science2021，32，4： | 4 |
| 9 | Dissecting Abscisic Acid Signaling Pathways Involved in Cuticle Formation显示文摘表皮是在植物和环境之间的天线植物表面和一个重要相互作用点的外部物理障碍。许多环境压力影响表皮形成,然而,包含的规章的小径仍然保持未定义。我们在 Arabidopsis thaliana 使用了遗传和基因表达式分析定义表明断然经由表明小径的核心骆驼毛的织物调整表皮形成的循环的 abscisic 酸(骆驼毛的织物) ,包括 PYR/PYL 受体, PP2C 磷酸酶,和 SNF1 相关的蛋白质 Kinase (SnRK ) 2.2/SnRK2.3/SnRK2.6。SnRK2 kinases 下游,表皮形成没被骆驼毛的织物应答的元素绑定抄写因素,但是由相当调整使脱蜡, MYB16, MYB94,和 MYB96。另外,低空气湿度增加了核心骆驼毛的织物小径和表明表皮生合成基因的稀释表示的房间 death/reactive 氧种类的表皮形成独立人士。在 Physcomitrella 圣餐盘,外长的骆驼毛的织物压制了表皮相关的基因的表示, orthologs 是其 Arabidopsis 导致骆驼毛的织物。因此,调整表皮形成的机制被保存但是在陆地植物复杂。与表皮缺乏有关明确地发信号被识别在表明小径异种到增加的湿度并且在 modulating 的骆驼毛的织物的改编起一个主要作用他们的免疫到在 Arabidopsis 的 Botrytis cinerea。这些结果在表明调整回答到外部环境的小径的 ABA 定义一个表皮特定的下游的分支。 | Fuqiang Cui Mikael Brosche Mikko T. Lehtonen Ali Amiryousefi Enjun Xu Matleena Punkkinen Jari P.T. Valkonen Hiroaki Fujii Kirk Overmyer | 2016 | Molecular Plant2016，9，6： | 3 |
| 10 | Burnout and work engagement among teachers显示文摘 | Jari J. Hakanen Arnold B. Bakker Wilmar B. Schaufeli | 2005 | Journal of School Psychology2005，，6： | 3 |
| 11 | Feasibility of Pulse Combustion in Micro Gas Turbines显示文摘In gas turbines, a fast decrease of efficiency appears when the output decreases; the efficiency of a large gas turbine (20…30 MW) is in the order of 40 %, the efficiency of a 30 kW gas turbine with a recuperator is in the order of 25 %, but the efficiency of a very small gas turbine (2…6 kW) in the order of 4…6 % (or 8…12 % with an optimal recuperator). This is mainly a result of the efficiency decrease in kinetic compressors, due to the Reynolds number effect. Losses in decelerating flow in a flow passage are sensitive to the Reynolds number effects. In contrary to the compression, the efficiency of expansion in turbines is not so sensitive to the Reynolds number; very small turbines are made with rather good efficiency because the flow acceleration stabilizes the boundary layer. This study presents a system where the kinetic compressor of a gas turbine is replaced with a pulse combustor. The combustor is filled with a combustible gas mixture, ignited, and the generated high pressure gas is expanded in the turbine. The process is repeated frequently, thus producing a pulsating flow to the turbine; or almost a uniform flow, if several parallel combustors are used and triggered alternately in a proper way. Almost all the compression work is made by the temperature increase from the combustion. This gas turbine type is investigated theoretically and its combustor also experimentally with the conclusion that in a 2 kW power size, the pulse flow gas turbine is not as attractive as expected due to the big size and weight of parallel combustors and due to the efficiency being in the order of 8 % to 10 %. However, in special applications having a very low power demand, below 1000 W, this solution has better properties when compared to the conventional gas turbine and it could be worth of a more detailed investigation. | Juha Honkatukia Esa Saari Timo Knuuttila Jaakko Larjola Jari Backman | 2012 | Journal of Thermal Science2012，21，5： | 2 |
| 12 | On the threshold setting principles in code acquisition of DS-SS signals显示文摘 | Jari H J Iinatti | 2000 | IEEE Journal on selected Areas in Communications2000，8，1： | 2 |
| 13 | Fluxes of methane, carbon dioxide and nitrous oxide in boreal lakes and potential anthropogenic effects on the aquatic greenhouse gas emissions显示文摘 | Jari T. Huttunen Jukka Alm Anu Liikanen Sari Juutinen Tuula Larmola Taina Hammar Jouko Silvola Pertti J. Martikainen | 2003 | Chemosphere2003，，3： | 2 |
| 14 | LTE网络规划和优化的特点及路测实例显示文摘LTE试验和部署正在全球范围展开,本文探讨了LTE这一新技术在网络规划和优化上特点,重点分析了路测系统中特性参数,用于衡量LTE网络性能KPI。 | Jari Ryynanen 张文果 | 2011 | 电信网技术2011，，5： | 2 |
| 15 | Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling显示文摘We examine the role of big data and machine learning in cancer research.We describe an example in cancer research where gene-level data from The Cancer Genome Atlas(TCGA) consortium is interpreted using a pathway-level model.As the complexity of computational models increases,their sample requirements grow exponentially.This growth stems from the fact that the number of combinations of variables grows exponentially as the number of variables increases.Thus,a large sample size is needed.The number of variables in a computational model can be reduced by incorporating biological knowledge.One particularly successful way of doing this is by using available gene regulatory,signaling,metabolic,or context-specific pathway information.We conclude that the incorporation of existing biological knowledge is essential for the progress in using big data for cancer research. | Jari Yli-Hietanen Antti Ylipää Olli Yli-Harja | 2015 | Chinese Journal of Cancer2015，34，10： | 2 |
| 16 | Alzheimer病与脑缺血的相互作用聚焦炎症显示文摘进行性记忆障碍、与局部炎症相关的β-淀粉样蛋白(β-amyloid,Aβ)斑块、神经原纤维缠结和选择性脑区神经元脱失是Alzheimer病(Alzheimer’s disease,AD)的特征。虽然β-淀粉样前体蛋白(β-amyloid precursor protein,APP)和Aβ在AD的病因学中起关键作用,但究竟何种形式的APP或Aβ与AD脑内的神经元易损性有关仍不清楚。最近已经公认,作为老年人痴呆的另一种病因,脑缺血促进了AD的发病,而认知功能严重减退的患者和潜在的AD患者发生脑缺血事件的风险增高。此外,载脂蛋白E(apolipoprotein E,ApoE)ε4等位基因既是AD的危险因素,也是脑缺血和脑出血后转归不良的危险因素。最近已经报道了AD模型中降低神经元死亡阈值的一些因素和分子机制,在这些神经炎症中似乎起着重要的作用。在中枢神经系统中,AD神经病理学和缺血性损伤的发展和成熟均以神经胶质细胞活化和炎症介质上调为特征。业已证实,抗炎症策略对体内AD样神经病理学和缺血性损伤的预防和治疗的确有益。本文对提示人APP在神经元的过度表达促使脑更易遭受缺血性损伤的一些研究结果进行了总结,并对增强神经元对缺血性卒中易感性的一些因素做了介绍。 | Milla Koistinaho Jari Koistinaho 郑莹 袁宝玉 闫福岭 | 2006 | 国际脑血管病杂志2006，14，11： | 2 |
| 17 | Application of three-dimensional electrical resistance tomography to characterize gas holdup distribution in laboratory flotation cell显示文摘 | Jari Kourunen Timo Niitti Lasse M. Heikkinen | 2011 | Minerals Engineering2011，，15： | 2 |
| 18 | Quantifying temporal changes in Tornionjoki river ice breakup dates and spring temperatures in Lapland since 1802显示文摘Cryophenological 记录(即观察系列结冰并且冰的决裂日期) 当在冷区域估计环境变化时,是很重要的。这里,我们在北 Fennoscandia 采用了河冰决裂日期和空气温度的非常地长的观察记录自从 1802,检验他们的相互关系。与现代数据一起,历史的观察为用 t 测试执行的这分析包括参考设置。4 月 5 月季节的温度历史为决裂 timings 被用作气候的对应物。两个记录(温度和决裂) 在他们的本地工具相对前面、随后的亚时期在哪个期间是显然不同的期间显示出七亚时期。这些亚时期的开始并且结束的年发生在时间的同意。这研究的主要调查结果如下被总结:(1 ) 在温度和河冰决裂记录之间的 synchrony 排除了变化将由于历史的系列的质量发生的可能性(即不同类问题经常连接了到历史的时间系列) ;( 2 )学习记录同意在 第19 世纪期间显示出更低的春天温度和以后的河冰决裂,与 第20 个世纪条件相比,证实在学习区域的更凉爽的春天温度的流行,与在西北欧洲的小冰川期( 15701900 )气候的概念一致;(3 ) 最近的亚时期与附随地最早的河冰决裂表明最高的春天温度,在过去的二个世纪的上下文在学习区域显示出当前的春季气候的相对温暖;(4 ) 在河环境的人为的变化的效果(例如水坝的建设和拆毁) 应该在决裂记录为非气候的变化在第 20 世纪期间被考虑;(5 ) 这研究强调重要性多一世纪(即历史) 为气候和环境历史的高度有趣的观点的 cryophenological 信息。 | Samuli HELAMA Jianmin JIANG Johanna KORHONEN Jari HOLOPAINEN Mauri TIMONEN | 2013 | Journal of Geographical Sciences2013，23，6： | 2 |
| 19 | The Foundations of Jurgen Habennas's Di course Ethics 显示文摘 | Jari Ilmari Niemi | 2008 | The Journal of Value Inquiry2008，，42： | 1 |
| 20 | Evolutionary Bi--objective Optimization in the Elevator carrouting Problem显示文摘 | Tapio Yyni Jari Ylinen | 2006 | European Journal of Operational Research2006，169，5： | 1 |
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