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| 1 | Draft Genome Sequence of Mentha Iongifolia and Development of Resources for Mint Cultivar Improvement显示文摘类 Mentha 包含为他们的香精油栽培的薄荷种类,它被提出进消费者产品的一个广阔数组。到真菌的疾病 Verticillium 的理想的油特征和抵抗枯萎是为薄荷工业的最高的优先级。然而,栽培了薄荷有复杂多倍体染色体并且是无菌的。因此,繁殖努力为肥沃的薄荷种类要求 genomic 资源的发展。这里,我们为 Mentha longifolia (L.) 的枯萎抵抗的南非的就职的现在的草稿 de novo 染色体和 plastome 集会 Huds,对栽培薄荷油和荷兰薄荷祖先的双种。353 Mb 染色体包含 35 597 预言了编码蛋白质的基因,包括决定香精油特征的 292 个疾病抵抗基因相当或相同的事物,和九基因。一张基因连接地图在 12 pseudochromosomes 上订了 1397 染色体脚手架。超过 200 万次简单顺序重复被识别,它将便于分子的标记开发。M。longifolia 染色体是为新陈代谢的工程并且分子的繁殖的一个珍贵资源。这被采用染色体顺序在薄荷油栽培变种克隆并且机能上地描绘倡导者例示,并且表明一个腺的毛状体特定的倡导者的实用程序增加 biosynthetic 基因的表示,从而 modulating 香精油作文。 | Kelly J. Vining Sean R. Johnson Amirhossein Ahkami Iris Lange Amber N. Parrish Susan C. Trapp Rodney B. Croteau Shannon C.K. Straub Iovanna Pandelova B. Markus Lange | 2017 | Molecular Plant2017，10，2： | 5 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients显示文摘Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation. | Mark Schrader Markus Müller Rüdiger Heicappell Bernd Straub Kurt Miller | 2001 | Asian Journal of Andrology2001，3，4： | 3 |
| 4 | Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines显示文摘 | Tobias Birnbaum Julia Roider Christoph J. Schankin Claudio S. Padovan Christian Schichor Roland Goldbrunner Andreas Straube | 2007 | Journal of Neuro - Oncology2007，，3： | 2 |
| 5 | Polymers of N-vinylpyrrolidone:synthesis, characterization and uses 显示文摘 | Haaf F Sanner A Straub F | 1985 | Polym J (Tokyo)1985，17，1： | 2 |
| 6 | 水基清洗技术——航空航天零件工业绿色清洗技术介绍(二) | 易举 孙卓 Rainer Straub | 2009 | 国防制造技术2009，0，6： | 2 |
| 7 | The effect of montelukast on exhaled nitric oxide and lung function in asthmatic children 2 to 5 years old显示文摘 | Straub DA Minocchieri S Moeller A | 2005 | Chest2005，127，2： | 1 |
| 8 | Complex-shaped three-dimensional microstructures and photonic crystals generated in a polysiloxane polymer by two-photon microstereolithography显示文摘 | STRAUB M NGUYEN L H FAZLIC A | 2004 | Optical Materials2004，27，3： | 1 |
| 9 | Design and testing of a double X-frame piezoelectric actuator显示文摘 | Hall S R Tzianetopolou T Straub F | 2000 | Smart Structures and Integrated Systems2000，3985，： | 1 |
| 10 | The process of aging changes the interplay of the immune,endocrine and nervous systems显示文摘 | Straub RH Cutolo M Zietz B | 2001 | Mech Ageing Dev2001，122，14： | 1 |
| 11 | Self-consistent tight-binding theory of elasticity in ionic solids显示文摘 | Straub G K Harrison W A | 1989 | Phys Rev B1989，39，10： | 1 |
| 12 | Structure and promoter analysis of an ABAand stress-regulated barley gene HVA1 显示文摘 | Straub P F Shen Q Ho T D | 1994 | Plant Molecular Biology1994，26，： | 1 |
| 13 | Simultaneous multiresidue analysis of beta - lactam antibiotics in bovine milk by liquid chromatography with ultraviolet detection and confirmation by electrospray mass spectrometry 显示文摘 | Tyczkowska KL Voyksner RD Straub RF | 1994 | J Assec Off Anal Chem1994，77，5： | 1 |
| 14 | The formation of biogenic amines by fermentation organisms显示文摘 | Straub B W Kieherer M Sehileher S M | 1995 | Zeitschrift furr Lebensmittel-Untersuchung und-Forschung1995，201，： | 1 |
| 15 | Hyperon nucleon interaction and the H dibaryon in the quark cluster model 显示文摘 | STRAUB U ZHANG Z Y BRAUER K | 1990 | Nucl Phys1990，508，： | 1 |
| 16 | Automated methods for multiplexed pathogen detection显示文摘 | Straub TM Dockendorff BP Quinonez-Diaz MD | 2005 | J Microbiol Methods2005，62，3： | 1 |
| 17 | Instruments in MIS research显示文摘 | Straub D Validating W | 1989 | MIS Quarterly1989，13，2： | 1 |
| 18 | The criteria of the international headache society for Tolosa-Hunt syndrome need to be revised显示文摘 | Forderreuther S Straube A | | 0，，： | 1 |
| 19 | Rivaroxaban:anew oral factor Xa inhibitor 显示文摘 | Perzbom E Roehrig S Straub A | 2010 | Arterioscler Thromb VaseBiol2010，30，3： | 1 |
| 20 | Consumer Trust in B2C E-Commerce and the Importance of Social Presence: Experiments in E-Products and E-Services 显示文摘 | Gefen D Straub D W | 2004 | Om- ega2004，32，6： | 1 |
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