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1Curcumin-primed and curcuminloaded exosomes:potential neural therapy显示文摘Curcumin:Curcumin is a yellow colored compound found in the rhizomes of Curcuma longa(turmeric),a member of the ginger family(Zingiberaceae).Structurally curcumin is a diarylheptanoid,a tautomeric compound,present in keto form in water and enolic form in the organic solvents.The therapeuticAnuradha Kalani Pankaj Chaturvedi 2017Neural Regeneration Research2017,12,2:6
2A high methionine,low folate and vitamin B_6/B_(12) containing diet can be associated with memory loss by epigenetic silencing of netrin-1显示文摘Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current study.We hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing global DNA methylation and therefore,silencing the netrin-1 gene,which encodes the glycoprotein involved in neurogenesis,axonal guidance and maintenance of the synaptic plasticity.Wild type(C57 BL/6 J) mice were fed with a diet containing excess methionine(1.2%),low-folate(0.08 mg/kg),vitamin B_6(0.01 mg/kg),and B_(12)(10.4 mg/kg) for 6 weeks.Mice were examined weekly for the long-term memory function,using a passive avoidance test,which determined loss of fear-motivated long-term memory starting from the fourth week of diet.Similarly,an increase in brain %5-methyl cytosine was observed starting from the 4 th week of diet in mice.Mice fed with a high methionine,low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation,as determined by methylation-sensitive restriction enzyme-polymerase chain reaction analysis.The increase in methylation of netrin-1 gene was validated by high-resolution melting and sequencing analysis.Furthermore,the association of netrin-1 with memory was established by administering netrin that considerably restored long-term fear motivated memory.Taken together,these results suggest that a diet rich in methionine and lacking in folate and vitamin B_6/B_(12) can induce defects in learning and memory.Furthermore,the data indicates that decrease in netrin-1 expression due to hyper-methylation of its gene can be associated with memory loss.The animal procedures were approved by the Institutional Animal Care and Use Committee,University of Louisville,USA(No.A3586-01) on February 2,2018.Anuradha Kalani Pankaj Chaturvedi Komal Kalani Pradip K.Kamat Poonam Chaturvedi Neetu Tyagi 2019Neural Regeneration Research2019,14,7:4
3Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran显示文摘AIM: To determine the causative agents of spontaneous bacterial peritonitis (SBP) in children with liver disease and ascites in our center.METHODS: During a 2.5 year period, from September 2003 to March 2006, 12 patients with 13 episodes of SBP were studied. In all cases at the time of admission serum albumin and glucose, urinalysis and urine culture was performed. Analysis [white blood cell (WBC) count with differential, albumin, glucose], gram stain, culture by BACTEC method and antibiogram was done on ascitic fluids. Abdominal paracentesis was repeated after 48 h of antibiotic therapy for bacteriologic assay. The patients were followed for at least three months in a gastroenterology clinic. RESULTS: There were 7 girls (58%) and 5 boys (42%) with a median age of 5.2 years (range, 6 mo to 16 years). All cases had positive ascitic fluid culture. Gram stain was positive in 5 (38.5%) of them. The isolated organisms were S. pneumoniae in 5 (38.5%), E. coli in 2 (15.3%), S. viridans in 2 (15.3%), and K. pneumoniae, H. influenza, Enterococci, and nontypable Streptococcus each in one (7.7%). All of them except Enterococci were sensitive to ciprofloxacin and ceftriaxone. All ascitic fluid cultures were negative after 48 h of antibiotic therapy. CONCLUSION: S. pneumoniae is the most common cause of SBP in the pediatric age group and we recom-mend a third generation cephalosporine (e.g., Ceftriax-ione or Cefotaxime) for empirical therapy in children with SBP.Mahmood Haghighat Seyed Mohsen Dehghani Abdolvahab Alborzi Mohammad Hadi Imanieh Bahman Pourabbas Mehdi Kalani 2006World Journal of Gastroenterology2006,12,36:4
4Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives显示文摘Exosomes:Exosomes are a sub-population of micro-vesicles ranging from 40–100 nm that were earlier thought as artefacts under electron microscope.They recently came into attention for their storage of biological information,cell-to-cell communication,serving as biomarkers and potential use inAnuradha Kalani Neetu Tyagi 2015Neural Regeneration Research2015,10,10:3
5One stop shop IV: taxonomic update with molecular phylogeny for important phytopathogenic genera: 76-100 (2020)显示文摘This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and fungus-like organisms.This paper focuses on one family:Erysiphaceae and 24 phytopathogenic genera:Armillaria,Barrio-psis,Cercospora,Cladosporium,Clinoconidium,Colletotrichum,Cylindrocladiella,Dothidotthia,,Fomitopsis,Ganoderma,Golovinomyces,Heterobasidium,Meliola,Mucor,Neoerysiphe,Nothophoma,Phellinus,Phytophthora,Pseudoseptoria,Pythium,Rhizopus,Stemphylium,Thyrostroma and Wojnowiciella.Each genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.Species confirmed with pathogenicity studies are denoted when data are available.Six of the genera are updated from previous entries as many new species have been described.Ruvishika S.Jayawardena Kevin D.Hyde Yi Jyun Chen Viktor Papp Balázs Palla Dávid Papp Chitrabhanu S.Bhunjun Vedprakash G.Hurdeal Chanokned Senwanna Ishara S.Manawasinghe Dulanjalee L.Harischandra Ajay Kumar Gautam Shubhi Avasthi Boontiya Chuankid Ishani D.Goonasekara Sinang Hongsanan XiangYu Zeng Kapila K.Liyanage NingGuo Liu Anuruddha Karunarathna Kalani K.Hapuarachchi Thatsanee Luangharn Olivier Raspé Rashika Brahmanage Mingkwan Doilom Hyang B.Lee Liu Mei Rajesh Jeewon Naruemon Huanraluek Napalai Chaiwan Marc Stadler Yong Wang 2020Fungal Diversity2020,,4:2
6Effect of Dalteparin on Healing of Chronic Foot Ulcers in Diabetic Patients With Peripheral Arterial Occlusive Disease显示文摘Kalani M Apelqvist J Blomback M 2003Diabetes Care(S1475--3898)2003,26,:1
7Optimizing supercritical an tisolvent process parameters to minimize the particle size of paracetamol nanoencapsulated in L-polylactide显示文摘Kalani M Yunus R Abdullah N Int J Nano medicine0,6,:1
8Wnt-signaling in retinal development and disease显示文摘Lad EM Cheshier SH Kalani MY 2009Stem Cells Dev2009,18,1:1
9Genetics of the degenerated intervertebral disc 显示文摘Kalb S Martirosyan NL Kalani MY 2012World Neurosurgery2012,77,34:1
10Treating superficial venous thrombophlebitis显示文摘Lee JT Kalani MA 2008J Natl Compr Canc Netw2008,6,8:1
11Early micro vascu- lar dysfunction in healthy normal-weight males with he- redity for type 2 diabetes显示文摘Jorneskog G Kalani M Kuhl J 2005Diabetes Care2005,28,6:1
12Effect of Surface Treatment on Diffusion and Domain Formation in Supported Lipid Bilayers显示文摘Kalani J. Seu Anjan P. Pandey Farzin Haque Elizabeth A. Proctor Alexander E. Ribbe Jennifer S. Hovis 2007Biophysical Journal2007,,7:1
13Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes显示文摘Papadogeorgos NO Bengtsson M Kalani M 2009Vasc Health Risk Manag2009,,5:1
14Design, synthe-sis and in vitro evaluation of 18 p-glycyrrhetinic acid derivativesfor anticancer activity against human breast cancer cell line Mcf-7显示文摘YADAV D K KALANI K SINGH A K ef al 2014Cun Med Chem2014,21,9:1
15Commercial banking crises in Kenya:Causes and remedies显示文摘Waweru N M Kalani V M 2009African Journal of Accounting Economics Finance and banking research2009,4,4:1
16Susceptibility patterns and cross-resistance of antibiotics against Pseudomonas aeruginosa isolated from burn patients in the South of Iran显示文摘Japoni A Alborzi A Kalani M 2006Burns2006,32,3:1
17Seroprevalence of ehikungunya virus(CHIKV) infection on lamu island,Kenya,Oc- tober 2004 显示文摘SERGON K NJUGUNA C KALANI R 2008Am J Trop Med Hyg2008,78,2:1
18Depositional environments and sequence stratigraphy of the Early Triassic Kangan Formation in the northern part of the Persian Gulf:Implications for reservoir characteristics 显示文摘Peyravi M Kamali M R Kalani M 2010Journal of Petroleum Geology2010,33,4:1
19Susceptibility patterns and cross-resistance of antibiotics against pseudomonas aeruginosa isolated from burn patients in the South of Iran显示文摘Japoni A Alborzi A Kalani M 0,,:1
20Relationship between γ‐interferon gene polymorphisms and susceptibility to brucellosis infection显示文摘Ebrahim Eskandari‐Nasab Mehdi Moghadampour Seyed‐Shahaboddin Hasani Mehdi Hadadi‐fishani Seyyed‐Ali Mirghanizadeh‐Bafghi Abolghasem Asadi‐Saghandi Fateme Zare Behrooz Sadeghi‐Kalani Mehran Ghazali‐bina 2013Microbiol Immunol2013,,:1
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