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| 1 | Giant cavernous liver hemangiomas: is it the time to change the size categories?显示文摘BACKGROUND: Four different sizes(4, 5, 8 and 10 cm in diameter) can be found in the literature to categorize a liver hemangioma as giant. The present review aims to clarify the appropriateness of the size category 'giant' for liver hemangioma.DATA SOURCES: We reviewed the reports on the categorization of hemangioma published between 1970 and 2014. The number of hemangiomas, size criteria, mean and range of hemangioma sizes, and number of asymptomatic and symptomatic patients were investigated in patients aged over 18 years. Liver hemangiomas were divided into four groups: <5.0 cm, 5.0-9.9 cm, 10.0-14.9 cm and ≥15.0 cm in diameter. Inclusion criteria were noted in 34 articles involving 1972(43.0%) hemangiomas(>4.0 cm).RESULTS: The patients were divided into the following groups: 154 patients(30.0%) with hemangiomas less than 5.0 cm in diameter(small), 182(35.5%) between 5.0 cm and 9.9 cm(large), 75(14.6%) between 10.0 and 14.9 cm(giant), and 102(19.9%) more than 15.0 cm(enormous). There were 786(39.9%) asymptomatic patients and 791(40.1%) symptomatic patients. Indications for surgery related to symptoms were reported in only 75(3.8%) patients. Operations including 137 non-anatomical resection(12.9%) and 469 enucleation(44.1%) were unclearly related to size and symptoms.CONCLUSIONS: The term 'giant' seems to be justified for liver hemangiomas with a diameter of 10 cm. Hemangiomas categorized as 'giant' are not indicated for surgery. Surgery should be performed only when other symptoms are apparent. | isidoro di carlo renol koshy saif al mudares annalisa ardiri gaetano bertino adriana toro | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 22 |
| 2 | CD13 is a therapeutic target in human liver cancer stem cells显示文摘 | Haraguchi Naotsugu Ishii Hideshi Mimori Koshi Tanaka Fumiaki Ohkuma Masahisa Kim Ho Min Akita Hirofumi Takiuchi Daisuke Hatano Hisanori Nagano Hiroaki Barnard Graham F Doki Yuichiro Mori Masaki | 2010 | Journal of Clinical Investigation2010，，9： | 7 |
| 3 | Protocol liver biopsy is the only examination that can detect mid-term graft fibrosis after pediatric liver transplantation显示文摘AIM:To assessed the clinical significance of protocol liver biopsy(PLB)in pediatric liver transplantation(LT).METHODS:Between July 2008 and August 2012,89and 55 PLBs were performed in pediatric patients at two and five years after LT,respectively.We assessed the histopathological findings using the Metavir scoring system,including activity(A)and fibrosis(F),and we identified factors associated with scores of≥A1 and≥F1.Our results clarified the timing and effectiveness of PLB.RESULTS:The incidences of scores of≥A1 and≥F1 were 24.7%and 24.7%,respectively,at two years after LT and 42.3%and 34.5%,respectively,at five years.Independent risk factors in a multivariate analysis of a score of≥A1 at two years included≥2 h ofcold ischemic time,no acute cellular rejection and an alanine amino transaminase(ALT)level of≥20 IU/L(P=0.028,P=0.033 and P=0.012,respectively);however,no risk factors were identified for a score of≥F1.Furthermore,no independent risk factors associated with scores of≥A1 and≥F1 at five years were identified using multivariate analysis.A ROC curve analysis of ALT at two years for a score of≥A1 demonstrated the recommended cutoff value for diagnosing≥A1 histology to be 20 IU/L.The incidence of scores of≥A2 or≥F2 at two years after LT was 3.4%(three cases),and all patients had an absolute score of≥A2.In contrast to that observed for PLBs at five years after LT,the incidence of scores of≥A2 or≥F2 was 20.0%(11 cases),and all patients had an absolute score of≥F2.In all cases,the dose of immunosuppressants was increased after the PLB,and all ten patients who underwent a follow-up liver biopsy improved to scores of≤A1 or F1.CONCLUSION:PLB at two years after LT is an unnecessary examination,because the serum ALT level reflects portal inflammation.In addition,immunosuppressive therapy should be modulated to maintain the ALT concentration at a level less than 20 IU/L.PLB at five years is an excellent examination for the detection of early reversible graft fibrosis because no serum markers reflect this finding. | Yukihiro Sanada Koshi Matsumoto Taizen Urahashi Yoshiyuki Ihara Taiichi Wakiya Noriki Okada Naoya Yamada Yuta Hirata Koichi Mizuta | 2014 | World Journal of Gastroenterology2014，20，21： | 5 |
| 4 | Achieving higher strength in Cu–Ag–Zr alloy by warm/hot rolling显示文摘High-strength Cu–3Ag–0.5Zr alloy plates were produced by multi-pass rolling in the temperature range of500–800 °C. An increase in strength was observed by rolling in the aforementioned range without significant loss in ductility. All the rolled samples show higher strength than solution-treated and aged samples. The maximum strength was observed for plates rolled at 500 °C with a yield strength and ultimate tensile strength of 311 and385 MPa, respectively, and retaining a ductility of 23 %.Transmission electron microscopy(TEM) studies showed uniform distribution of fine silver precipitates and high dislocation density in the rolled samples. Nevertheless, the size of precipitates and dislocation density varied with the rolling temperature. The superior strength achieved in the rolled samples is attributed to grain refinement, dislocation strengthening, and precipitation hardening. This method can be employed to produce high-strength plates of precipitation hardenable copper alloys. | S. Chenna Krishna Abhay K. Jha Bhanu Pant Koshy M. George | 2017 | Rare Metals2017，36，4： | 4 |
| 5 | Effect of atrial natriuretic peptide on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model显示文摘AIM: To evaluate the effect of ANP on warm I/R injury in a porcine THVE model. METHODS: Miniature pigs (mini-pigs) weighing 16-24 kg were observed for 120 min after reperfusion following 120 min of THVE. The animals were divided into two groups. ANP (0.1 μg/kg per min) was administered to the ANP group (n = 7), and vehicle was administered to the control group (n = 7). Either vehicle or ANP was intravenously administered from 30 min before the THVE to the end of the experiment. Arterial blood was collected to measure AST, LDH, and TNF-α. Hepatic tissue blood ? ow (HTBF) was also measured. Liver specimens were harvested for p38 MAPK analysis and histological study. Those results were compared between the two groups. RESULTS: The AST and LDH levels were lower in the ANP group than in the control group; the AST levels were signifi cantly different between the two groups (60 min: 568.7 ± 113.3 vs 321.6 ± 60.1, P = 0.038 < 0.05, 120 min: 673.6 ± 148.2 vs 281.1 ± 44.8, P = 0.004 < 0.01). No signifi cant difference was observed in the TNF-α levels between the two groups. HTBF was higher in the ANP group, but the difference was not signif icant. A signifi cantly higher level of phosphorylated p38 MAPK was observed in the ANP group compared to the controlgroup (0 min: 2.92 ± 1.1 vs 6.38 ± 1.1, P = 0.011 < 0.05).Histological tissue damage was milder in the ANP group than in the control group. CONCLUSION: Our results show that ANP has a protective role in I/R injury with p38 MAPK activation in a porcine THVE model. | Katsumi Kobayashi Kiyohiro Oshima Masato Muraoka Takahiko Akao Osamu Totsuka Hisashi Shimizu Hiroaki Sato Kazumi Tanaka Kenjiro Konno Koshi Matsumoto Izumi Takeyoshi | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 6 | Relationship between urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study in Japan显示文摘背景几研究建议了到镉( Cd )的暴露从肾的疾病,心血管的疾病和恶意的瘤增加了死亡,在住在 弄脏Cd 的区域和工厂 workers.This 学习的居民之中包括肺癌症和前列腺癌症试图在住在一个区域的居民的长期的结果上估计环境暴露的影响到 Cd 由 Cd.Methods A 弄脏22年的后续学习与 3119 个居民( 1403 个男人和 1716 个女人)一起被进行 1.64 ( 95 C/ 1.17-2.28 )并且 1.78 ( 95 C/ 1.27-2.50 )为 women.The 大多数,死亡的经常的原因是恶意的在男人的瘤和在 women.The 的心血管的疾病为心血管的疾病的死亡风险的重要增加与 10 g/g 在这些题目被观察在为男人的两 sexes:1.79 的 Cr ( 95 Cl 1.02-3.12 )并且 2.38 为女人( 95 CI 1.11-5.07 ) .When 这些题目被划分成 2 个范畴( 20 g/g Cr 和 20 g/g Cr ),为肾炎和肾变病的尿 Cd 20 g/g Cr 组的 HR 是 4. | LI Qian Muneko Nishijo Hideaki Nakagawa Yuko Morikawa Masaru Sakurai Koshi Nakarnura Teruhiko Kido Koji Nogawa DAI Min | 2011 | Chinese Medical Journal2011，，21： | 3 |
| 7 | Prognostic Significance of Complications after Curative Surgery for Gastric Cancer显示文摘 | Takeshi Kubota Naoki Hiki Takeshi Sano Shogo Nomura Souya Nunobe Koshi Kumagai Susumu Aikou Ryohei Watanabe Toshiyuki Kosuga Toshiharu Yamaguchi | 2014 | Annals of Surgical Oncology2014，，3： | 2 |
| 8 | Clinical significance of the expression of long non-coding RNA HOTAIRin primary hepatocellular carcinoma显示文摘 | Masahisa Ishibashi Ryunosuke Kogo Kohei Shibata Genta Sawada Yusuke Takahashi Junji Kurashige Sayuri Akiyoshi Shin Sasaki Takeshi Iwaya Tomoya Sudo Keishi Sugimachi Koshi Mimori Go Wakabayashi Masaki Mori | 2013 | Oncology Reports2013，，3： | 2 |
| 9 | Novel powellite-based red-emitting phosphors: CaLa 1? x NbMoO 8 : x Eu 3+ for white light emitting diodes显示文摘 | Mariyam Thomas P. Prabhakar Rao M. Deepa M.R. Chandran Peter Koshy | 2008 | Journal of Solid State Chemistry2008，，1： | 2 |
| 10 | Adaptive control of a class of nonlinear time-varying systems with multiple models显示文摘在未知却变化时间的参数是线性的非线性的系统的适应控制在这份报纸被对待。因为令人满意的短暂性能是一个重要因素,当这些参数在参数空格突然地变化,多重模型被要求。在这份报纸,我们与为系统的这个班与第二水平改编象多重模型一样交换并且调节方法论认为两个是多重模型。我们证明后者途径比前者好。 | Koshy GEORGE Karpagavalli SUBRAMANIAN | 2016 | Control Theory and Technology2016，14，4： | 2 |
| 11 | Over- and under-expressed microRNAs in human colorectal cancer显示文摘 | Kazuo Motoyama Hiroshi Inoue Yasushi Takatsuno Fumiaki Tanaka Koshi Mimori Hiroyuki Uetake Kenichi Sugihara Masaki Mori | 2009 | International Journal of Oncology2009，，4： | 2 |
| 12 | Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathologicalsignificance显示文摘 | Yojiro Hashiguchi Naohiro Nishida Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Hidetaka Mochizuki Kazuo Hase Yuichiro Doki Masaki Mori | 2012 | International Journal of Oncology2012，，5： | 2 |
| 13 | Multicenter study evaluating the clinical performance of the OSNA assay for the molecular detection of lymph node metastases in gastric cancer patients显示文摘 | Koshi Kumagai Noriko Yamamoto Isao Miyashiro Yasuhiko Tomita Hitoshi Katai Ryoji Kushima Hitoshi Tsuda Yuko Kitagawa Hiroya Takeuchi Makio Mukai Masayuki Mano Hidetaka Mochizuki Yo Kato Nariaki Matsuura Takeshi Sano | 2014 | Gastric Cancer2014，，2： | 2 |
| 14 | Radiation interception and use by maize/peanut intercrop canopy显示文摘 | M.A. Awal H. Koshi T. Ikeda | 2006 | Agricultural and Forest Meteorology2006，，1： | 2 |
| 15 | Hypertension and medical expenditure in the Japanese population:Review of prospective studies显示文摘Hypertension is a major determinant of health and is likely to have an effect on medical economics.The economic burden due to hypertension may be attributable not only to antihypertensive medication but also to the very expensive procedures required for cases of cardiovascular disease that occur more frequently in hypertensive compared with normotensive individuals.The objective of this article was to review articles published on prospective cohort studies that measured medical expenditure attributable to hypertension in community-dwelling populations in Japan.Many medical services in these populations are provided under the medical insurance system that requires the enrolment of all Japanese residents.Personal medical expenditure attributable to hypertension increases with worsening severity of the condition.Medical expenditure was increased further in cases of hypertensive patients who have another concomitant cardiovascular risk factor.In particular,hypertension,especially moderate-to-severe untreated hypertension,increases the risk of long-term hospitalization resulting in considerably higher medical expenditure,compared with non-hospitalized cases.Therefore,assuming that the use of antihypertensive medication is essential for hypertensive patients to prevent serious vascular diseases,a cost-effective highrisk strategy needs to be considered to reduce both ill-health and the economic burden due to hypertension.However,from a population perspective,medical expenditure attributable to hypertension comes mainly from pre-to-mild hypertension.Therefore,there is also a need to consider a population strategy that aims to shift the entire population to lower levels of blood pressure. | Koshi Nakamura Tomonori Okamura Katsuyuki Miura Akira Okayama | 2014 | World Journal of Cardiology2014，6，7： | 2 |
| 16 | K-Ar Dating of Fault Gouges from the Red River Fault Zone of Vietnam显示文摘Constraining the timing of fault zone formation is fundamentally important in terms of geotectonics to understand structural evolution and brittle fault processes.This paper presents the first authigenic illite K-Ar age data from fault gouge samples collected from the Red River Shear Zone at Lao Cai province,Vietnam.The fault gouge samples were separated into three grain-size fractions(<0.1 μm,0.1-0.4 μm and 0.4-1.0 μm).The results show that the K-Ar age values decrease from coarser to finer grain fractions(24.1 to 19.2 Ma),suggesting enrichment in finer fraction of morerecently grown authigenic illites.The timing of the fault movement are the lower intercept ages at 0%detrital illite(19.2 ± 0.92 Ma and 19.4 ± 0.49 Ma).In combination with previous geochronological data,this result indicates that the metamorphism of the Day Nui Con Voi(DNCV) metamorphic complex took place before ca.26.8 Ma.At about 26.8 Ma-25 Ma,the fault strongly acted to cause the rapid exhumation of the rocks along the Red River-Ailoa Shan Fault Zone(RR-ASFZ).During brittle deformation,the DNCV slowly uplifted,implying weak movement of the fault.This brittle deformation might have lasted for ca.5 Ma. | BUI Hoang Bac NGO Xuan Thanh Yungoo SONG Tetsumaru ITAYA Koshi YAGI KHUONG The Hung NGUYEN Tien Dung | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 2 |
| 17 | Friction and wear property of α-CNx coatings sliding against ceramic and steel balls water显示文摘 | ZHOU Fei Koshi A Koji K | 2005 | Diamond and Related Materials2005，14，： | 1 |
| 18 | Single-level instrumented postero- lateral fusion versus non-instrumented anterior interbody fusion for lumbar spondylolisthesis : a prospective study with a 2-year follow-up 显示文摘 | Ohtori S Koshi T Yamashita M | 2011 | J Or- thop Sci2011，4，： | 1 |
| 19 | High Speed End Milling of Hardened AISI D2 Tool Steel (58HRC) 显示文摘 | KOSHY P | 2002 | Journal of Materials Processing Technology2002，127，5： | 1 |
| 20 | Multiple Management Modalities in Esophageal Cancer:Epidemiology,Presentation and Progression,Work-up,and Surgical Approaches显示文摘 | Koshy M Esiashvilli N Landry JC | | 0，，： | 1 |
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