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		题名	作者	年代	出处	被引量
	1	Clinical significance of HOTAIR expression in colon cancer显示文摘AIM: To detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer. METHODS: Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. Quantitative polymerase chain reaction was used to detect the expression of HOTAIR. The relationship between the expression of HOTAIR and clinicopathological parameters of colon cancer was analyzed. RESULTS: The expression of HOTAIR was significantly higher in colon cancer tissues than in matched tumoradjacent normal colon tissues(P < 0.05). HOTAIR expression was significantly higher in cases with lymph node metastasis than in those without metastasis; in lowly differentiated and undifferentiated cases than in highly and moderately differentiated cases; and in stages Ⅲ + Ⅳ cases than in stages?Ⅰ?+ Ⅱ cases(P < 0.05).CONCLUSION: HOTAIR expression is upregulated in colon cancer, suggesting that HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer.	Zhi-Fen Luo Dan Zhao Xi-Qing Li Yong-Xia Cui Ning Ma Chuang-Xin Lu Ming-Yue Liu Yun Zhou	2016	World Journal of Gastroenterology2016，22，22：	14
	2	LncRNAs在消化系统疾病中的研究进展显示文摘长链非编码RNA(lncRNAs)是一类长度超过200个核苷酸且无蛋白质编码功能的RNA,能在表观遗传学、转录和转录后水平调控基因表达,广泛参与机体生理和病理过程。近年研究发现lncRNAs在多种消化系统疾病的发生、发展过程中发挥作用,对lncRNAs的研究将为这些疾病发生的预测、诊断和治疗以及预后评估提供有价值的信息。本文在简要介绍lncRNAs基本概念的基础上,对相关研究进展作一综述。	周军李善高	2014	胃肠病学2014，19，7：	0

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