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| 1 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 2 | Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease显示文摘AIM: To determine factors predictive for esophageal varices in severe alcoholic disease (SAD). METHODS: Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS: Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type Ⅳ collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78. CONCLUSION: This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD. | Satoshi Mamori Yasuyuki Searashi Masato Matsushima Kenichi Hashimoto Shinichiro Uetake Hiroshi Matsudaira Shuji Ito Hisato Nakajima Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 3 | Study protocol of the Asian XELIRI ProjecT(AXEPT):a multinational,randomized,non-inferiority,phase Ⅲ trial of second-line chemotherapy for metastatic colorectal cancer, comparing the eicacy and safety of XELIRI with or without bevacizumab versus FOLFIRI w显示文摘Background: Capecitabine and irinotecan combination therapy(XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer(m CRC). Recently, in the Association of Medical Oncology of the German Cancer Society(AIO) 0604 trial, tri?weekly XELIRI plus bevacizumab, with reduced doses of irinotecan(200 mg/m^2 on day 1) and capecitabine(1600 mg/m^2 on days 1–14), repeated every 3 weeks, has shown favorable tolerability and eicacy which were comparable to those of capecitabine and oxaliplatin(XELOX) plus bevacizumab. The doses of capecit?abine and irinotecan in the AIO trial are considered optimal. In a phase I/II study, XELIRI plus bevacizumab(BIX) as second?line chemotherapy was well tolerated and had promising eicacy in Japanese patients.Methods: The Asian XELIRI Projec T(AXEPT) is an East Asian collaborative, open?labelled, randomized, phase Ⅲ clinical trial which was designed to demonstrate the non?inferiority of XELIRI with or without bevacizumab versus standard FOLFIRI(5?fluorouracil, leucovorin, and irinotecan combination) with or without bevacizumab as second?line chemo?therapy for patients with m CRC. Patients with 20 years of age or older, histologically conirmed m CRC, Eastern Coop?erative Oncology Group performance status 0–2, adequate organ function, and disease progression or intolerance of the irst?line regimen will be eligible. Patients will be randomized(1:1) to receive standard FOLFIRI with or with?out bevacizumab(5 mg/kg on day 1), repeated every 2 weeks(FOLIRI arm) or XELIRI with or without bevacizumab(7.5 mg/kg on day 1), repeated every 3 weeks(XELIRI arm). A total of 464 events were estimated as necessary to show non?inferiority with a power of 80% at a one?sided α of 0.025, requiring a target sample size of 600 patients. The 95% conidence interval(CI) upper limit of the hazard ratio was pre?speciied as less than 1.3.Conclusion: The Asian XELIRI Projec T is a multinational phase III trial being conducted to provide evidence for XELIRI with or without bevacizumab as a second?line treatment option of mCRC. | Masahito Kotaka Ruihua Xu Kei Muro Young Suk Park Satoshi Morita Satoru Iwasa Hiroyuki Uetake Tomohiro Nishina Hiroaki Nozawa Hiroshi Matsumoto Kentaro Yamazaki Sae-Won Han Wei Wang Joong Bae Ahn Yanhong Deng Sang-Hee Cho Yi Ba Keun-Wook Lee Tao Zhang Taroh Satoh Marc E.Buyse Baek-Yeol Ryoo Lin Shen Junichi Sakamoto Tae Won Kim | 2016 | Chinese Journal of Cancer2016，35，12： | 3 |
| 4 | Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer. | Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 5 | Over-the-scope-clipping system for anastomotic leak after colorectal surgery:Report of two cases显示文摘An anastomotic leak is one of the major complications following colorectal surgery.Standard treatments for anastomotic leak are total parenteral nutrition or temporary ileostomy.The over-the-scope-clipping(OTSC)system was originally developed to treat intestinal perforation or to close the tissue after natural orifice transluminal endoscopic surgery.Two cases of successful management of an anastomotic leak after colorectal surgery using the OTSC system are reported.One patient avoided a temporary ileostomy.In the other,hospitalization was shortened by the use of the OTSC system.The OTSC system can be a potential option in the management of anastomotic leaks after colorectal surgery. | Hirotoshi Kobayashi Akifumi Kikuchi Satoshi Okazaki Megumi Ishiguro Toshiaki Ishikawa Satoru Iida Hiroyuki Uetake Kenichi Sugihara | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 6 | 结肠直肠癌中VEGF-C与Cox-2的共表达及与淋巴结转移的关系显示文摘PURPOSE:Several lines of experimental evidence indicated that over-expression of vascular endothelial growth factor-C and cyclooxygenase-2 genes promotes angiogenesis and lymphangiogenesis,both of which are essential for the growth and spreading of tumor cells.This study was designed to evaluate the coexpression of vascular endothelial growth factor-C and cyclooxygenase-2 in human colorectal carcinoma to determine their relationships and correlations with lymph node metastasis and prognosis.METHODS:Tissue samples of primary tumors and metastatic lymph nodes from 150 patients undergoing intentionally curative surgical resections for colorectal adenocarcinoma were immunohistochemically examined for vascular endothelial growth factor-C,cyclooxygenase-2,and CD34 expressions.Then,we analyzed their relationships and correlations with clinicopathologic findings and patients’survival time.RESULTS:The positivity rate of vascular endothelial growth factor-C and cyclooxygenase-2 in the primary tumor was 68 and 72.7 percent,respectively,and in the metastatic lymph nodes was 93.3 and 80 percent,respectively.A significant correlation was found between the expression scores of vascular endothelial growth factor-C and cyclooxygenase-2(P < 0.0001),and both also were correlated to microvessels density and several clinicopathologic parameters,including primary tumor size,lymph node metastasis,lymphatic invasion,and TNM stage.Patients with vascular endothelial growth factor-C-positive and/or cyclooxygenase-2-positive tumors had a significant shorter survival time than those with negative tumors did.However,in a multivariate analysis,only cyclooxygenase-2 expression was recognized as an independent prognostic factor(P = 0.0412;relative risk ratio,3.067;95 percent confidence interval,1.046-8.994).CONCLUSIONS:These data show that in human colorectal carcinoma,vascular endothelial growth factor-C and cyclooxygenase-2 are coexpressed and significantly associated with lymph node metastasis and prognosis. | Soumaoro L.T. Uetake H. Takagi Y. 廖新华 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 2 |
| 7 | Over- and under-expressed microRNAs in human colorectal cancer显示文摘 | Kazuo Motoyama Hiroshi Inoue Yasushi Takatsuno Fumiaki Tanaka Koshi Mimori Hiroyuki Uetake Kenichi Sugihara Masaki Mori | 2009 | International Journal of Oncology2009，，4： | 2 |
| 8 | Therapeutic strategies for hepatic metastasis of colorectal cancer: overview显示文摘 | Kenichi Sugihara Hiroyuki Uetake | 2012 | Journal of Hepato-Biliary-Pancreatic Sciences2012，，5： | 2 |
| 9 | Methylation of BNIP3 and DAPK indicates lower response to chemotherapyand poor prognosis in gastric cancer显示文摘 | Hirofumi Sugita Satoru Iida Mikito Inokuchi Keiji Kato Megumi Ishiguro Toshiaki Ishikawa Yoko Takagi Megumu Enjoji Hiroyuki Yamada Hiroyuki Uetake Kazuyuki Kojima Kenichi Sugihara | 2011 | Oncology Reports2011，，2： | 2 |
| 10 | Coexpression of VEGF-C and COX-2 in human colorectal cancer and its association with lymph node metastasis 显示文摘 | Soumaoro L T Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 11 | Efficacy of laser capture microdisseetion plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer 显示文摘 | Makino H Uetake H Danenberg K | 2008 | BMC Cancer2008，8，2： | 1 |
| 12 | Combination of dihydropy- rimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoro- pyrimidine- based chemotherapy for metastatic colorectal cancer 显示文摘 | Iehikawa W Uetake H Shirota Y | 2003 | Clin Cancer IRes2003，9，： | 1 |
| 13 | Cyclooxygenase-2 expression:a significant prognostic indicator for patients with colorectal cancer显示文摘 | SOUMAORO L T UETAKE H HIGUCHI T | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 14 | Coexpression of VEGF-C and COX-2 in humacolorectal cancer and its association with lymph nodmetastasis 显示文摘 | Soumaoro L T Uetake H Takagi Y | 2006 | Dis Colon Rec-tum2006，49，3： | 1 |
| 15 | Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test显示文摘 | Masaki Kakimoto Hiroyuki Uetake Takayuki Osanai Yoshinori Shirota Yoko Takagi Emiko Takeshita Yoichi Toriya Kathleen Danenberg Peter V. Danenberg Kenichi Sugihara | 2004 | Cancer Letters2004，，1： | 1 |
| 16 | Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis 显示文摘 | Soumaoro LT Uetake H Takagi Y | 2006 | Dis Colon Rectum2006，49，3： | 1 |
| 17 | Adaptive Roll- over Prevention Controller {or Driver-vehicle Systems 显示文摘 | UETAKE Y OYA M SHU P | 2014 | Artificial Life & Robotics2014，19，1： | 1 |
| 18 | Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer 显示文摘 | Kato K Iida S Uetake H | 2008 | Int J Cancer2008，122，3： | 1 |
| 19 | Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer显示文摘 | Soumaoro LT Uetake H Higuchi T | 2004 | Clin Cancer Res2004，10，： | 1 |
| 20 | Second--line chemotherapy for advanced colorectal cancer显示文摘 | Uetake H fida S Tsunozatd H | 2005 | Gan To Kagaku Ryoho2005，32，1： | 1 |
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