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356篇 您的检索式:作者名="KESSLER T"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2The use of 3-Ddose volume analysis to predict radiation hepatitis显示文摘Lawrence T S Ten Haken R K Kessler M L 1992Int J Radiat Oncol Biol Phys1992,23,9:1
3Improved laser-beam uniformity using the angular dispersion of frequency-modulated light显示文摘Skupsky S Short R W Kessler T 1989J Appl Phys1989,66,:1
4Angiogenesis inhibition in cancer therapy:platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors:biological functions and role in malignancy显示文摘Appelmann I Liersch R Kessler T 0,,:1
5Disruption of matrix metallo- proteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiugenesis and tumor growth in vivo显示文摘Silletti S Kessler T Goldberg J 2001Proc Nat Acad Sci USA2001,98,1:1
6查看详情显示文摘Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D 0,,:1
7OMEGA EP high-energy petawatt laser: progress and prospects显示文摘D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien 2008Journal of Physics: Conference Series2008,,3:1
8Rimximabin combina-tion with platinum-containig chemotherapy in patients with relapsed or primary refractory diffuse large B-cell lymphoma显示文摘 Kessler T Berdel W E 2003Oncol Rep2003,10,6:1
9In situ poly- (urea- formaldehyde) microencapsulation of dicyclopentadiene 显示文摘Brown E N Kesslers M R Sottost N T 2003Journal of Microencapsulation2003,20,6:1
10Clinical risk management in hospitals:strategy,central coordination and dialogue as key enablers显示文摘Briner M Manser T Kessler O 2013J Eval Clin Praet2013,19,2:1
11Proteglycans on bone marrow endothelial cells bind and present SDF-1 towards hematopoietic progenitor cells 显示文摘Netelenbos T van den Born J Kessler FL Zweeqman S Merle PA van Oostveen JW 2003Leukemia2003,17,1:1
12Manufacture and Development of Multilayer Diffraction Gratings 显示文摘KECK J OLIVER J B KESSLER T J 2005Proc SPIE2005,5991,:1
13Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo显示文摘Sillelti S Kessler T Goldberg J 2001Proc Natl Acad Sci USA2001,98,1:1
14Fracture mechanisms of the Strombus gigas conch shell : implica-tions for the design of brittle laminates 显示文摘KUHN- SPEARING L T KESSLER H CHATEAU E 1996Journal of MaterialsScience1996,31,24:1
15Sporadic focal dystonia in northwest Germany:molecular basis on chromosome 18p 显示文摘Leube B Hendgen T Kessler KR 1997Ann Neurol1997,42,:1
16Nerve sparing open radical retropubic prostatectomy-does it have an impact on urinary continence?显示文摘Burkhard F C Kessler T M Fleischmann A 2006J Urol2006,176,1:1
17Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon-and interferon-stimulated genes but is not a primary transcriptional activator of either 显示文摘Pine R Decker T Kessler D S 1990Mol Cell Biol1990,10,:1
18Vascular endothelial growth factor and its receptor as drug targets in hematological malignancies显示文摘Kessler T Fehrmann F Bieker R 2007Curr Drug Targets2007,8,3:1
19Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy显示文摘Appelmann I Liersch R Kessler T 2010Recent Results Cancer Res2010,180,:1
20Long- term results of surgery for urethral strieture:a statis tical analysis显示文摘Kessler T M Schreiter F Kralidis G 2003J Urol2003,170,:1
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