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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | 饮水微量元素与老年人群认知能力关系研究显示文摘在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。 | 梁超轲 吉荣娣 曹静祥 姜玉亭 余波 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie | 2003 | 卫生研究2003，32，5： | 12 |
| 3 | Nutrient Intakes of Pregnant Women and their Associated Factors in Eight Cities of China: A Cross-sectional Study显示文摘 | Fang-Li Liu Yu-Mei Zhang Gerard Vinyes Pares Kathleen C Reidy Wen-Zhi Zhao Ai Zhao Cheng Chen Celia Y Ning Ying-Dong Zheng Pei-Yu Wang | 2015 | Chinese Medical Journal2015，，13： | 12 |
| 4 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 5 | Adrenomedullin and endocrine control of immune cells during pregnancy显示文摘怀孕的免疫学复杂、不完全地听说。在蜕膜并且在胎盘的异常有免疫力的活动被相信在怀孕的疾病起一个作用,例如不孕,流产,胎儿的生长限制和 preeclampsia。这里,我们简短由肽荷尔蒙 adrenomedullin 考察子宫的自然漂亮房间人口和他们的功能的内分泌的控制。在基因动物模型的研究在母亲胎儿的接口揭示了 adrenomedullin 剂量的批评重要性,与从两个的细胞贡献位于适当子宫的感受性,培植并且螺线动脉的脉管的改变下面的必要方面的母亲、胎儿的分隔空间。这些基本卓见进串音在之间内分泌并且在母亲胎儿的接口以内的免疫系统可以最终在临床上复杂的怀孕翻译到功能的更好的理解和 dysregulated adrenomedullin 层次的后果。 | Brooke C Matson Kathleen M Caron | 2014 | Cellular & Molecular Immunology2014，11，5： | 4 |
| 6 | Screening for gestational diabetes: a summary of the evidence for the U.S. Preventive Services Task Force显示文摘 | Seth C Brody Russell Harris Kathleen Lohr | 2003 | Obstetrics & Gynecology2003，，2： | 3 |
| 7 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 8 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 9 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 10 | Cellular location of transforming growth factor β1 expression in bleomycin-induced pulmonary fibrosis显示文摘 | Kathleen C Flander S | 1995 | Am J Pathol1995，147，： | 1 |
| 11 | Experience with PICC at a university medical center显示文摘 | | 1997 | J Intraven Nuts1997，20，6： | 1 |
| 12 | Experience with PICC at a university medical center显示文摘 | Kathleen C | 1997 | Intraven Nurs1997，20，5： | 1 |
| 13 | Bringing Engineer- ing Research to Market: How Universities, Industry and Government Are Attempting to Solve the Problem显示文摘 | Allen Kathleen R Taylor Cyrus C | 2005 | Engineering Management Journal2005，17，3： | 1 |
| 14 | Experience with PICC at a U- niversity Medical Center 显示文摘 | Kathleen M D Christine D C | 1997 | Ioumal of Infusion Nursing1997，20，6： | 1 |
| 15 | Solution-liquid-solid growth of crystalline iii-v semiconductors--An analogy to vapor-liquid-solid growth 显示文摘 | Trentler Timothy J Hickman Kathleen M Goel Subhash C | 1995 | Science1995，270，5243： | 1 |
| 16 | Contribution of increased endolymphatic pressure to hearing loss in experimental hydrops显示文摘 | Kathleen C Homer KC | 1991 | Ann Otol Rhinol Laryngol1991，100，6： | 1 |
| 17 | Experience with PICC at a university medical center显示文摘 | Kathleen C L | 1997 | J Interaven Nurs1997，20，6： | 1 |
| 18 | Organizational Adaptation 显示文摘 | Kathleen M C | 1998 | Annals of Operations Research1998，，75： | 1 |
| 19 | The ultrasonographic appearance of ovarian ectopic pregnancies显示文摘 | Christine C Kathleen H Wesley L | 2005 | Obstet Gynecol2005，105，： | 1 |
| 20 | Effects of immediate versus delayed pushing during second-stage labor on fetal well-being:a randomized clinical trial显示文摘 | Simpson Kathleen Rice James Dotti C | 2005 | blursing Research2005，54，3： | 1 |
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