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| 1 | Lipids in liver transplant recipients显示文摘Hyperlipidemia is very common after liver transplantation and can be observed in up to 71% of patients. The etiology of lipid disorders in these patients is multifactorial, with different lipid profiles observed depending on the immunosuppressive agents administered and the presence of additional risk factors, such as obesity, diabetes mellitus and nutrition. Due to recent improvements in survival of liver transplant recipients, the prevention of cardiovascular events has become more important, especially as approximately 64% of liver transplant recipients present with an increased risk of cardiovascular events. Management of dyslipidemia and of other modifiable cardiovascular risk factors, such as hypertension, diabetes and smoking, has therefore become essential in these patients. Treatment of hyperlipidemia after liver transplantation consists of life style modification, modifying the dose or type of immunosuppressive agents and use of lipid lowering agents. At the start of administration of lipid lowering medications, it is important to monitor drugdrug interactions, especially between lipid lowering agents and immunosuppressive drugs. Furthermore, as combinations of various lipid lowering drugs can lead to severe side effects, such as myopathies and rhabdomyolysis, these combinations should therefore be avoided. To our knowledge, there are no current guidelines targeting the management of lipid metabolism disorders in liver transplant recipients. This paper therefore recommends an approach of managing lipid abnormalities occurring after liver transplantation. | anna hüsing iyad kabar hartmut h schmidt | 2016 | World Journal of Gastroenterology2016，22，12： | 6 |
| 2 | Single-operator cholangioscopy for biliary complications in liver transplant recipients显示文摘AIM To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography(ERCP) for management of biliary complications after liver transplantation(LT).METHODS Twenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy s y s t e m(S py G la s s D S ?) wa s pe r fo r me d dur ing the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility testing.RESULTS Thirty-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14(53.8%) patients, non-anastomotic strictures in seven(26.9%), biliary cast in three(11.5%), and stones in six(23.1%). A benefit of cholangioscopy was seen in 12(46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive(43.2%), 12(32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic antibiotics.CONCLUSION Single-operator cholangioscopy can provide important diagnostic information, helping endoscopists to plan and perform interventional procedures in LT-related biliary complications. | Anna Hüsing-Kabar Hauke Sebastian Heinzow Hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 3 | Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation显示文摘AIM:To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon(PEB) for biliary anastomotic stricture(AS) after liver transplantation(LT).METHODS:This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014.The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography(ERCP).In cases of re-stenosis,further balloon dilation with a PEB was performed.Follow-up was continued until 24 mo after the last intervention.RESULTS:Initial technical feasibility,defined as successful balloon dilation with a PEB during the initial ERCP procedure,was achieved in 100% of cases.Long-term clinical success(LTCS),defined as no need for further endoscopic intervention for at least 24 mo,was achieved in 12 of the 13 patients(92.3%).The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1.Treatment failure,defined as the need for definitive alternative treatment,occurred in only one patient,who developed recurrent stenosis with increasing bile duct dilatation that required stent placement.CONCLUSION:Endoscopic therapy with a PEB is very effective for the treatment of AS after LT,and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS. | Anna Hüsing Holger Reinecke Vito R Cicinnati Susanne Beckebaum Christian Wilms Hartmut H Schmidt Iyad Kabar | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 4 | Use of paclitaxel-eluting balloons for endotherapy of anastomotic strictures following liver transplantation显示文摘 | I. Kabar V. Cicinnati S. Beckebaum S. Cordesmeyer Y. Avsar H. Reinecke H. Schmidt | 2012 | Endoscopy2012，，12： | 2 |
| 5 | MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity显示文摘 | Leibo Xu Susanne Beckebaum Speranta Iacob Gang Wu Gernot M. Kaiser Arnold Radtke Chao Liu Iyad Kabar Hartmut H. Schmidt Xiaoyong Zhang Mengji Lu Vito R. Cicinnati | 2013 | Journal of Hepatology2013，，： | 2 |
| 6 | Wound healing and facial growth after fetal cleft lip repair显示文摘 | Longaker MT Stern M | 1991 | Oral Maxillofac Surg Clin North Am1991，3，： | 1 |
| 7 | Effect of kinetin and gibberellic acid in overcoming high temperature and salinity (NaCl)stresses on the germination of barley and lettuce seeds显示文摘 | KABAR K BELTEPE S | | 0，，： | 1 |
| 8 | Effects of some plant growth regulators on stem anatomy of radish seedlings grown under saline (NaC1) conditions 显示文摘 | Cavulu K Klhc S Kabar K | 2008 | Plant Soil Environ2008，54，10： | 1 |
| 9 | 351 Endoscopic Ultrasound Guided Radiofrequency Ablation (EUS-RFA) for Cystic Neoplasms and Neuroendocrine Tumors of the Pancreas显示文摘 | Madhava Pai Hakan Senturk Sundeep Lakhtakia D. Nageshwar Reddy Vito Cicinnati Iyad Kabar Susanne Beckebaum Zhendong Jin Dong Wang Jianfeng Yang Xiaofeng Zhang Michel Kahaleh Nagy Habib William R. Brugge | 2013 | Gastrointestinal Endoscopy2013，，5： | 1 |
| 10 | Retrograde Intrarenal Surgery in Cross-fused Ectopic Kidney显示文摘 | Mustafa Resorlu Mucahit Kabar Berkan Resorlu Omer Gokhan Doluoglu Muhammet Fatih Kilinc Tolga Karakan | 2014 | Urology2014，，： | 1 |
| 11 | Calcineurin inhibitors in liver transplantation – still champions or threatened by serious competitors?显示文摘 | Susanne Beckebaum Vito R. Cicinnati Arnold Radtke Iyad Kabar | 2013 | Liver Int2013，，5： | 1 |
| 12 | Effects of 24 - epibrassinolide on salinity stress induced inhibition of seed germination, seedling growth and leaf anatomy of Barley显示文摘 | Kiliq S Cavasogm K Kabar K | 2007 | Sdfi Fen Edebiyat Fakultesi Fen Dergiisi(E-dergi)2007，2，1： | 1 |
| 13 | The Patterns of Expression of an Apoptosis-Related CK18 Neoepitope, the bcl-2 Proto-Oncogene, and the Ki67 Proliferation Marker in Normal, Hyperplastic, and Malignant Endometrium显示文摘 | Hassan M. Morsi Mathie P.G. Leers Wolfram J?ger Viveka Bj?rklund Martin Radespiel-Tr?ger Hamdy El Kabarity Marius Nap Norbert Lang | 2000 | International Journal of Gynecological Pathology2000，，2： | 1 |
| 14 | Some morphological and anatomical observations during alleviation of salinity (NaCI) stress on seed germination and seedling growth of barley by polyamines 显示文摘 | CAVUSOCLU K KILIC S KABAR K | 2007 | Acta Physiol Plant2007，29，6： | 1 |
| 15 | Introducing Paclitaxel-Eluting Balloons as a New Treatment Option of Biliary-Enteric Anastomotic Stricture After Liver Transplantation显示文摘 | Iyad Kabar Vito R. Cicinnati Susanne Beckebaum Stefanie Cordesmeyer Holger Reinecke Hartmut H. Schmidt | 2012 | Transplantation Journal2012，，1： | 1 |
| 16 | Digital single-operator video cholangioscopy improves endoscopic management in patients with primary sclerosing cholangitis-a retrospective observational study显示文摘BACKGROUND Patients with primary sclerosing cholangitis(PSC)are at a high risk of developing cholestatic liver disease and biliary cancer,and endoscopy is crucial for the complex management of these patients.AIM To clarify the utility of recently introduced digital single-operator video cholangioscopy(SOVC)for the endoscopic management of PSC patients.METHODS In this observational study,all patients with a history of PSC and in whom digital SOVC(using the SpyGlass DS System)was performed between 2015 and 2019 were included and retrospectively analysed.Examinations were performed at a tertiary referral centre in Germany.In total,46 SOVCs performed in 38 patients with a history of PSC were identified.The primary endpoint was the evaluation of dominant biliary strictures using digital SOVC,and the secondary endpoints were the performance of selective guidewire passage across biliary strictures and the diagnosis and treatment of biliary stone disease in PSC patients.RESULTS The 22 of 38 patients had a dominant biliary stricture(57.9%).In 4 of these 22 patients,a cholangiocellular carcinoma was diagnosed within the stricture(18.2%).Diagnostic evaluation of dominant biliary strictures using optical signs showed a sensitivity of 75%and a specificity of 94.4%to detect malignant strictures,whereas SOVC-guided biopsies to gain tissue for histopathological analysis showed a sensitivity of 50%and a specificity of 100%.In 13%of examinations,SOVC was helpful for guidewire passage across biliary strictures that could not be passed by conventional methods(technical success rate 100%).Biliary stone disease was observed in 17.4%of examinations;of these,in 37.5%of examinations,biliary stones could only be visualized by SOVC and not by standard fluoroscopy.Biliary stone treatment was successful in all cases(100%);25%required SOVC-assisted electrohydraulic lithotripsy.Complications,such as postinterventional cholangitis and pancreatitis,occurred in 13%of examinations;however,no procedure-associated mortality occurred.CONCLUSION Digital SOVC is effective and safe for the endoscopic management of PSC patients and may be regularly considered an additive tool for the complex endoscopic management of these patients. | Arne Bokemeyer Frank Lenze Viorelia Stoica Timur Selcuk Sensoy Iyad Kabar Hartmut Schmidt Hansjoerg Ullerich | 2022 | World Journal of Gastroenterology2022，28，20： | 1 |
| 17 | Effects of pretreatments of some growth regulators on the stomata movements of bar- ley seedlings grown under saline ( NaCl ) conditions 显示文摘 | Qavusoglu K Kilic S Kabar K | 2007 | Plant Soil and Environment2007，53，： | 1 |
| 18 | Doxofylline: the next generation methyhanthine 显示文摘 | Sankar J Lodhar Kabar SK | 2008 | Indian J Pediatr2008，75，3： | 1 |
| 19 | Effect of kinetin and gibberellic acid in overcoming high temperature and salinity (NaC1) stresses on the germination of barley and lettuce seeds显示文摘 | KABAR K BELTEPE S | | 0，，： | 1 |
| 20 | Some morphological and anatomical observations during alleviation of salinity (NaCI) stress on seed germination and seedling growth of barley by polyamines显示文摘 | Kür?at ?avu?o?lu Semra K?l?? Kudret Kabar | 2007 | Acta Physiologiae Plantarum2007，，6： | 1 |
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