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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection显示文摘Hepatitis B virus(HBV)infection is still a public health problem worldwide,being endemic in some parts of the world.It can lead to serious liver diseases such as chronic hepatitis,cirrhosis,and hepatocellular cancer.The differences in host immune response can be one of the reasons for the various clinical presentations of HBV infection.Polymorphisms of genes encoding the proinflammatory and antiinflammatory cytokines,which are responsible for regulation of the immune response,can affect the clinical presentation of the infection.Particularly,the polymorphisms of the genes encoding cytokines such as interleukin(IL)-1,IL-6,IL-8,IL-10,IL-18,IL-28B,interferon-γ,tumor necrosis factor-α,tumor growth factor-β1,and regulatory molecules like vitamin D receptor and chemokine receptor 5 can be responsible for different clinical presentations of HBV infections.The genomic information about cytokines and other mediators can be important for determining high-risk people for developing chronic hepatitis or hepatocellular cancer and may be used to plan treatment and preventive approaches for these people.In this review,the current knowledge in the literature on the association between cytokine/regulatory molecule gene polymorphisms and clinical course of chronic HBV infec-tion is summarized,and the clinical implementations and future prospects regarding this knowledge are discussed. | Semra Tun?bilek | 2014 | World Journal of Gastroenterology2014，20，20： | 11 |
| 3 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 4 | Helicobacter pylori eradication in gastric diffuse large B cell lymphoma显示文摘Diffuse large B cell lymphoma(DLBCL) of the stomach is a heterogenous disease. There are tumors without histological evidence of mucosa-associated lymphoid tissue(MALT) lymphoma, which are classified as pure or de novo DLBCL and those with evidence of MALT, which are classified as DLBCL(MALT). The association between Helicobacter pylori(H. pylori) and gastric MALT lymphoma and remission with H. pylori eradication was shown in the 1990 s. In recent years, scientists from Taiwan and others have shown that high-grade gastric lymphomas may be dependent on H. pylori and eradication of this microorganism is effective in these cases. This entity is biologically distinct from H. pylori(-) cases and has a better clinical outcome. There are sufficient data about the complete remission in some of these cases with brief treatment with antibiotics. With this strategy, it is possible to save some of these cases from the harmful effects of standard chemotherapy. It is time to treat these cases with H. pylori eradication. However, strict histopathological follow-up is crucial and histopathological response must be evaluated according to the scoring system proposed by Groupe d'Etude des Lymphomes de l'Adulte. If there is no sufficient response, chemotherapy must be given immediately. These results suggest that H. pylori dependency and high-grade transformation in gastric MALT lymphomas are distinct events. | Semra Paydas | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 5 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 6 | Turkish version of the Omaha System:its use in practice-based family nursing education nurse education today显示文摘 | Semra E Nihal ME | 2006 | Nurse Education Today2006，26，： | 1 |
| 7 | Effect of atorvastatin on plasma fibrinogen显示文摘 | Wierzbicki AS Lumb PJ Semra YK | 1998 | Lancet1998，351，2： | 1 |
| 8 | Use of Fly Ash, Phosphogypsum and Red Mud as a Liner Material for the Disposal of Hazardous Zinc Leach Residue Waste显示文摘 | Semra orula Osman Nuri Ergun | 2010 | Journal of Hazardous Materials2010，，17313： | 1 |
| 9 | Application of a stage based motivational interviewing approach to adolescent smoking cessation: the trans-theoretical model-based study 显示文摘 | Saime Erol Semra Erdogan | 2008 | Patient Educ Couns2008，72，1： | 1 |
| 10 | Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women显示文摘 | Dogan Erdogan Hakan Gullu Erkan Yildirim Derya Tok Ismail Kirbas Ozgur Ciftci Semra Topcu Baycan Haldun Muderrisoglu | 2005 | Atherosclerosis2005，，2： | 1 |
| 11 | Granulocytic sarcoma: 32 cases and review of the literature显示文摘 | Semra Paydas Suzan Zorludemir Melek Ergin | 2006 | Leukemia & Lymphoma2006，，12： | 1 |
| 12 | Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets显示文摘 | Esber ? aglar Sule Kavaloglu Cildir Semra Ergeneli Nuket Sandalli Svante Twetman | 2006 | Acta Odontologica2006，，5： | 1 |
| 13 | Spectral broadening of lower extremity venous Doppler signals using STFT and AR modeling显示文摘 | KARA Sadik ICER Semra ERDOGAN Nuri | 2008 | Digital Signal Processing2008，18，4： | 1 |
| 14 | The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the en- docrine response to abdominal hysterectomy 显示文摘 | Semra D Suleyman GL Nurten A | 2004 | J Clin Anesth2004，16，5： | 1 |
| 15 | Silver,zinc,and copper exchange in a Naclinoptilolite and resulting effect on antibacterial activity 显示文摘 | Ayben Top Semra Ulku | 2004 | Applied Clay Science2004，27，： | 1 |
| 16 | Use of Fly Ash, Phc,sphogypsum and Red Mud as a Liner Material for the Disposal of Hazardous Zinc Leach Residue Waste显示文摘 | Semra Comh Osman Nuri Ergun | 2010 | Journal of Hazardous Materials2010，173，13： | 1 |
| 17 | A hybrid approach for the ca-pacitated lot sizing problem with setup carryover显示文摘 | Hacer G G Semra T Raf J | 2012 | Interna-tional Journal of Production Research2012，50，6： | 1 |
| 18 | Influence of psychosocial fac- tors on self - care hehaviors and glycemic control in turkish pa- tients with type 2 diabetes mellitus显示文摘 | Gulhan Cosansu Semra Erdogan | 2014 | Journal of Transcultural Nursing2014，25，1： | 1 |
| 19 | Proton magnetic resonance spectroscopy in three subacute sclerosing panencephalitis patients: correlation with clinical status显示文摘 | Handan Cakmakci Semra Kurul Akin Iscan Eray D?r?k | 2004 | Child’s Nervous System2004，，4： | 1 |
| 20 | Monitoring of buccal epithelial cells by alkaline comet assay ( single cell gel electrophoresis technique) in cytogenetic evaluation of chlorhexdine显示文摘 | Kaya E Nurdan O Semra S | 2002 | Clin Oral Invest2002，6，3： | 1 |
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