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| 1 | Gastric polypoid lesions:Analysis of 150 endoscopic polypectomy specimens from 91 patients显示文摘AIM: To analyze gastric polypoid lesions in our patientpopulation with respect to histopathologic features and demographic, clinical, and endoscopic characteristics of patients.METHODS: Clinical records and histopathologic reports of patients with gastric polypoid lesions were analyzed retrospectively. All lesions had been totally removed by either endoscopic polypectomy or hot biopsy forceps. The histopathologic slides were re-evaluated by the same histopathologist.RESULTS: One-hundred and fifty gastric polypoid lesions were identified in 91 patients. There were 53 (58%) women and 38 (42%) men with a median age of 53 (range, 31 to 82) years. The most frequent presenting symptom was dyspepsia that was observed in 35 (38.5%) patients.Symptoms were mostly related to various associated gastric abnormalities such as chronic gastritis or H pylori infection rather than polypoid lesion itself. Polypoid lesions were commonly located in the antrum followed by cardia. Out of 150 lesions, 80 (53%) had the largest dimensions less than or equal to 5 mm and only 7 were pedunculated. The frequencies of hyperplastic polyps, foveolar hyperplasia, and fundic gland polyps were 46%, 18%, and 14% respectively.We also detected gastritis varioliformis in 12 specimens,lymphoid follicles in 9, 4 adenomatous polyps in 4, polypoid lesions with edematous mucosa in 4, inflammatory polyps in 3, and carcinoid tumor in 1. Adenomatous changes were observed within two hyperplastic polyps and low grade dysplasia in one adenoma. Histopathologic evaluation of the surrounding gastric mucosa demonstrated chronic gastritis in 72 (79%) patients and H pylori infection in 45 (49%).CONCLUSION: Hyperplastic polyps are the most frequently encountered subtype of gastric polypoid lesions. They are usually associated with chronic gastritis or H pylori gastritis. Contrary to the previous belief, they may harbour adenomatous changes or dysplastic foci.Therefore, endoscopic polypectomy seems as a safe and fast procedure for both diagnosis and treatment of gastric polypoid lesions at the same session. In addition,edematous mucosa may appear misleadingly as a polypoid lesion in some instances and it can be ruled out only by histopathologic examination. | Rasim Gencosmanoglu Ebru Sen-Oran Ozlem Kurtkaya-Yapicier Erol Avsar Aydin Sav Nurdan Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 8 |
| 2 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 3 | Does N ratio affect survival in D1 and D2 lymph node dissection for gastric cancer?显示文摘AIM:To identify whether there could have been changes in survival if lymph node ratio (N ratio) had been used.METHODS:We assessed 334 gastric adenocarcinoma cases retrospectively between 2001 and 2009.Two hundred and sixteen patients out of 334 were included in the study.Patients were grouped according to disection1 (D1) or dissection 2 (D2) dissection.We compared the estimated survival and actual survival determined by Pathologic nodes (pN) class and N ratio,and SPSS 15.0 software was used for statistical analysis.RESULTS:Ninety-six (44.4%) patients underwent D1 dissection and 120 (55.6%) had D2 dissection.When groups were evaluated,23 (24.0%) patients in D1 and 21 (17.5%) in D2 had stage migration (P=0.001).When both D1 and D2 groups were evaluated for number of pathological lymph nodes,despite the fact that there was no difference in N ratio between D1 and D2 groups,a statistically significant difference was found between them with regard to pN1 and pN2 groups (P=0.047,P=0.044 respectively).In D1,pN0 had the longest survival while pN3 had the shortest.In D2,pN0 had the longest survival whereas pN3 had the shortest survival.CONCLUSION:N ratio is an accurate staging system for defining prognosis and treatment plan,thus decreasing methodological errors in gastric cancer staging. | Ibrahim Sakcak Baris Dogu Yildiz Fatih Mehmet Avsar Saadet Akturan Kemal Kilic Erdal Cosgun Enver O Hamamci | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 4 | L-carnitine alleviates sciatic nerve crush injury in rats:functional and electron microscopy assessments显示文摘Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus.It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats.Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes.After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days,axon area,myelin sheath area,axon diameter,myelin sheath diameter,and numerical density of the myelinated axons of injured sciatic nerve were similar to normal,and the function of injured sciatic nerve also improved significantly.These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats. | ümmü Zeynep Avsar Umit Avsar Ali Aydin Muhammed Yayla Berna Ozturkkaragoz Harun Un Murat Saritemur Tolga Mercantepe | 2014 | Neural Regeneration Research2014，9，10： | 3 |
| 5 | Use of paclitaxel-eluting balloons for endotherapy of anastomotic strictures following liver transplantation显示文摘 | I. Kabar V. Cicinnati S. Beckebaum S. Cordesmeyer Y. Avsar H. Reinecke H. Schmidt | 2012 | Endoscopy2012，，12： | 2 |
| 6 | Sea level change along the Black Sea coast from satellite altimetry, tide gauge and GPS observations显示文摘Sea level change affects human living conditions,particularly ocean coasts.However,sea level change is still unclear along the Black Sea coast due to lack of in-situ measurements and low resolution satellite data.In this paper,sea level change along the Black Sea coast is investigated from joint satellite altimetry,tide gauge(TG) and Global Positioning System(GPS) observations.The linear trend and seasonal components of sea level change are estimated at 8 TG stations(Amasra,Igneada,Trabzon-Ⅱ,Sinop,Sile,Poti,Tuapse,and Batumi) located along the Black Sea coast,which are compared with Satellite Altimetry and GPS.At the tide gauge stations with long-term records such as Poti(about 21 years) and Tuapse(about 19 years),the results obtained from the satellite altimetry and tide gauge observations show a remarkably good agreement.While some big differences are existed between Satellite Altimetry and TG at other stations,after adding vertical motion from GPS,correlation coefficients of the trend have been greatly improved from 0.37 to 0.99 at 3co-located GPS and TG stations(Trabzon-Ⅱ,Sinop and Sile). | Nevin B. Avsar Shuanggen Jin Hakan Kutoglu Ookhan Ourbuz | 2016 | Geodesy and Geodynamics2016，7，1： | 2 |
| 7 | Serum levels of omentin, chemerin and adipsin in patients with biopsy-proven nonalcoholic fatty liver disease显示文摘 | Yusuf Yilmaz Oya Yonal Ramazan Kurt Yesim Ozen Alahdab Fatih Eren Osman Ozdogan Cigdem Ataizi Celikel Nese Imeryuz Cem Kalayci Erol Avsar | 2011 | Scandinavian Journal of Gastroenterology2011，，1： | 1 |
| 8 | Change in response of bridges isolated with LRBs due to lead core heating显示文摘 | OZDEMIR G AVSAR O BAYHAN B | | 0，，07： | 1 |
| 9 | Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions显示文摘 | Avsar AF Avsar F Sahin M | 2003 | Eur J Obstet Gynecol Reprod Biol2003，106，1： | 1 |
| 10 | Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions显示文摘 | Avsar AF Avsar FM Sahin M | 2003 | Eur J Obstet Gynecol Reprod Biol2003，106，1： | 1 |
| 11 | Treatability of water-based paint wastewater with Fenton process in different reactor types 显示文摘 | KURT U AVSAR Y GONULLU M T | 2006 | Chemosphere2006，64，： | 1 |
| 12 | Cardiac autonomic function evaluated by the heart rate turbulence method was not changed in obese patients without co-morbidities 显示文摘 | Avsar A Acarturk G Melek M | 2007 | J Korean Med Sci2007，22，4： | 1 |
| 13 | Risk factors for ectopic pregnancy: a case control study显示文摘 | Karaer A Avsar FA | 2009 | Obstet Gynaecol2009，46，6： | 1 |
| 14 | Association of passive smoking with caries and related salivary biomarkers in young children 显示文摘 | Avsar A Darka O Topaloglu B | 2008 | Ar- chives of Oral Biology2008，53，10： | 1 |
| 15 | Induction and assessment methods used in experimental adhesion studies显示文摘 | OZEL H AVSAR F M TOPALOGLU S | 2005 | Wound Repair Regen2005，13，4： | 1 |
| 16 | Characterization of nutty flavor in cheddar cheese显示文摘 | AVSAR Y K KARAGUL-YUCEER Y DRAKE M A | 2004 | Dairy Sci2004，87，7： | 1 |
| 17 | Effects of rosiglitazone on methionine--choline deficient diet--induced nonalcoholic steatohepatitis显示文摘 | Tahan V Imeryuz N Avsar E | 2007 | Hepatology2007，46，6： | 1 |
| 18 | Two novel mutations in the sixth transmembrane segment of the thyrotrop in receptor gene causing hyperfunctioning thyroid nodules 显示文摘 | Gozu H Avsar M Bircan R | 2005 | Thyroid2005，15，4： | 1 |
| 19 | Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy显示文摘 | Avsar E Empson RM | 2004 | Neuropharmacology2004，47，3： | 1 |
| 20 | Tacrolimus versus cyclosporin induction therapy in pulmonary transplantation in miniature swine显示文摘 | Warnecke G Avsar M Steinkamp T | 2005 | Eur J Cardiothorac Surg2005，，： | 1 |
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