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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | 血液透析患者血压水平的地域和季节性差异显示文摘季节和气候对一般人群以及血液透析患者的血压调节有影响。目前这个现象在世界各地是否有所不同尚不清楚。研究者对来自7个欧洲国家(西班牙、意大利、法国、比利时、德国、英国和瑞典)2005-2011年间参加国际透析预后与实践模式研究(dialysis outcomes and practice patterns study,DOPPS)的患者进行了研究,目的是探究来自不同地理位置的血液透析患者的血压季节差异。 | 刘青 叶鹏 Duranton F Kramer A Szwarc I Bieber B Gayrard N Jover B Vetromile F Massy ZA Combe C Tentori F Jager KJ Servel MF Argilés | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 3 | Sustaining the gains made in malaria control and elimination显示文摘Significant progress has been made in the last 25 years to reduce the malaria burden,but considerable challenges remain.These gains have resulted from large investments in a range of control measures targeting malaria.Fana and co-authors find a strong relationship between education level and net usage with malaria parasitemia in pregnant women,suggesting the need for targeted control strategies.Mayala and co-workers find important links between agriculture and malaria with implications for inter-sectoral collaboration for malaria control. | Randall A Kramer Adriane Lesser | 2015 | Infectious Diseases of Poverty2015，4，1： | 4 |
| 4 | Leader behaviors and the work environment for creativity: Perceived leader support显示文摘 | Teresa M Amabile Elizabeth A Schatzel Giovanni B Moneta Steven J Kramer | 2004 | The Leadership Quarterly2004，，1： | 2 |
| 5 | Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI) 显示文摘 | Von Berg A Filipiak-Pittroff B Kramer U et ol | 2008 | J Allergy Clin Immunol2008，121，6： | 1 |
| 6 | Prevention of post-operative infections after surgical treatment of bite wounds 显示文摘 | Kramer A Assadian O Frank M | 2010 | GMS Krankenhhyg Interdiszip2010，5，2： | 1 |
| 7 | Assembly modeling by geometric constraint satisfaction 显示文摘 | Anantha R Kramer G A Crawford R H | 1996 | Computer-Aided Design1996，28，9： | 1 |
| 8 | Objective testing of vegetable quality显示文摘 | Kramer A | 1951 | Food Technology1951，，5： | 1 |
| 9 | Folate status Among Patients With Non-Small Cell Lung Cencer:A CaseControl Study显示文摘 | Jatoi A Daly BDT Kramer G | 2001 | J Surg Oncol2001，77，4： | 1 |
| 10 | Successful use of high dose rate brachytheray for nonmalignant bronchial obstruction显示文摘 | Kramer I R Katz A Yarmolovsky A | 2001 | Thorax2001，56，5： | 1 |
| 11 | Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podo- cin and the FERM domain protein Mosaic eyes 显示文摘 | KRAMER ZUCKER A G WIESSNER S JENSEN A M | 2005 | Dev Bio12005，285，： | 1 |
| 12 | Field-scale nitrogen balances associated with long-term continuous corn production显示文摘 | Karlen D L Kramer L A Logsdon S D | 1998 | Agronomy Journal1998，9，5： | 1 |
| 13 | Assessing contamination and compliance in the prostate component of the prostate,lung,colorectal,and ovarian (PLCO) Cancer Screening Trial显示文摘 | PINSKY PF BLACKA A KRAMER BS | | 0，，4： | 1 |
| 14 | Direct determination of the t matrix from a mom impedance matrix computed using the Rao Wilton Glisson basis function显示文摘 | Kim K T Kramer B A | 2013 | IEEETranson Antennas Propagation2013，61，53： | 1 |
| 15 | Renal replacement therapy in Europe:a summary of the 2011 ERA-EDTA Registry Annual Report显示文摘 | Noordzij M Kramer A Abad Diez JM et d | 2014 | Clin Kidney J2014，7，2： | 1 |
| 16 | Bulk heterojunction solar cell s:morphology and performance relationships显示文摘 | Ye H Kramer E J Heeger A J | 2014 | Chemical Reviews2014，114，14： | 1 |
| 17 | Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase(DGAT1) with variation at a quantitative trait locus for milk fat content显示文摘 | Winter A Kramer W Werner F A at al | 2002 | Proc Natl Sci USA2002，99，14： | 1 |
| 18 | 8-GHz Static Frequency Divider in AlInAs/InGaAs HBT Technology显示文摘 | Fields Charles H Stephen Thomas III Shi Binqiang Young Kim Boegeman Mary Montes Rosanna Martinez Kramer Allan R and Meena Madhav A Low-Power 72 | 2001 | IEEE JOURNAL OF SOLID-STATE CIRCUITS2001，36，： | 1 |
| 19 | Tympanometric screening in elementary school children显示文摘 | Page A Kramer S Novak J | 1995 | Audiology1995，34，： | 1 |
| 20 | Using radial basis functions to approximate a function and its error bounds显示文摘 | Leonard J A Kramer M A Ungar L H | 1992 | IEEE Transactions on Neural Networks1992，3，4： | 1 |
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