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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium显示文摘 | Andrew Kennedy Subir Nag Riad Salem Ravi Murthy Alexander J. McEwan Charles Nutting Al Benson Joseph Espat Jose Ignacio Bilbao Ricky A. Sharma James P. Thomas Douglas Coldwell | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 2 |
| 3 | Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart failu re 显示文摘 | Jose Carlos AL Juana CG Francesc F | 2013 | Cardiol J2013，20，5： | 1 |
| 4 | Therapeutic effect of recombinant vaccinia virus expressing the 60-KD heat-shock protein 显示文摘 | Jose AL Marin AO Eduardo P | 1990 | Clin Exp Immunol1990，81，： | 1 |
| 5 | Pleural fliud myeloperoxidase as a marker of infectious pleural effusions 显示文摘 | Jose AL Jordi JU Carmen AL | 2001 | Ear Inter Med2001，12，： | 1 |
| 6 | Homozygous Mutations in ADAMTS10 and ADAMTS17 Cause Lenticular Myopia, Ectopia Lentis, Glaucoma, Spherophakia, and Short Stature显示文摘 | Jose Morales Latifa Al-Sharif Dania S. Khalil Jameela M.A. Shinwari Prashant Bavi Rahima A. Al-Mahrouqi Ali Al-Rajhi Fowzan S. Alkuraya Brian F. Meyer Nada Al Tassan | 2009 | The American Journal of Human Genetics2009，，5： | 1 |
| 7 | Plasma homocysteine level- sand risk of Alzheimer disease 显示文摘 | Jose AL Ming_ Xin Tang Joshua M | 2004 | Neurology2004，62，11： | 1 |
| 8 | Critical success factors taxono- my for software process deployment 显示文摘 | Sussy B Jose A Gonzalo C eta al | 2014 | Software Qual J2014，，22： | 1 |
| 9 | Matrix converter: a technology review显示文摘 | PATRICK W W JOSE R JON C C et al | 2009 | IEEE Trans on Inst Elect2009，49，2： | 1 |
| 10 | Deep venous thrombosis显示文摘 | Jose AL Clive Keamn | 2004 | Hematology2004，，： | 1 |
| 11 | A comprehensive study of the synthesis,characterization and activity of TiO2 and mixed TiO2 SiO2 photocatalysts显示文摘 | Jose Aguado Rafael van Grieken Maria-Jose Lopez-Munoz ed al | 2006 | Applied Catalysis2006，3，12： | 1 |
| 12 | Relation of plasma homocysteine to plasma amyloid beta leve is 显示文摘 | Jose AL Ming Xin Tang Joshua M | 2007 | Neurochem Res2007，32，45： | 1 |
| 13 | Deep venous thrombosis 显示文摘 | Jose AL Clive Keamn | 2004 | Hematology2004，1，： | 1 |
| 14 | Effectsof Kinesio? Tape in low back muscle fatigue: Randomized,controlled, doubled- blinded clinical trial onhealthy subjects显示文摘 | Alvarez-álvarez S Jose FG Rodríguez-Fernández AL | 2013 | J Back Musculoskelet Rehabil2013，11，27： | 1 |
| 15 | Plasm volume expansion does not increase maximal cardiac output or O2max in lowlanders acclimatizatied to altitude显示文摘 | CALBET JOSE AL RADEGRAN G | 2004 | Am J Physiol Heart Circ Physiol2004，287，： | 1 |
| 16 | Deep venous thrombosis 显示文摘 | Jose AL Clive Kearon | 2004 | Hemetology2004，，： | 1 |
| 17 | Synthesis of deguelin-biotin conjugates and inves- tigation into deguelin's interactions 显示文摘 | Jose Garcia Sofia Barluenga Katarzyna Gorska et al | 2011 | Bioorganic & Medicinal Chemistry2011，20，2012： | 1 |
| 18 | Essential hypertension and histocompatibility antigens 显示文摘 | Maria GD Maria AL Jose JG | 1992 | Hypertension1992，19，： | 1 |
| 19 | Stability of anterior open-bite nonextraction treatment in the permanent dentition 显示文摘 | Guilherme J Fabricio PV Jose Fc ei al | 2003 | Am JOrthod Dentofacial Orthod2003，124，3： | 1 |
| 20 | Essential hypertension and histocompatibility antigens显示文摘 | Maria G D Maria AL Jose J G | 1992 | Hypertension1992，19，： | 1 |
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