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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | An ac- curate O(n) solution to the PnP problem显示文摘 | VINCENT L FRANCESC M PASCAL F | 2009 | Inter- national Journal of Computer Vision2009，81，2： | 1 |
| 3 | Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart failu re 显示文摘 | Jose Carlos AL Juana CG Francesc F | 2013 | Cardiol J2013，20，5： | 1 |
| 4 | Noise-robust watermarking for numerical datasets显示文摘 | FRANCESC S JOSEP D F AGUSTI S | 2005 | Lecture Notes in Computer Science2005，3558，： | 1 |
| 5 | Determination of macrolide antibiotics in meat and fish using pressurized liquid extraction and liquid chromatography-mass spectrometry显示文摘 | Houda B Francesc B Gullermina F | 2008 | Journal of Chromatography A2008，1208，12： | 1 |
| 6 | Primary small cell carcinoma of the esophagus:A review of the literature with emphasison the raphard prognosis显示文摘 | Francesc C Ferran F Blanca F | 1997 | Cancer1997，80，8： | 1 |
| 7 | EPnP:an accu-rate O(n)solution to the PnP problem显示文摘 | VINCENT L FRANCESC M N PASCAL F | | 0，，02： | 1 |
| 8 | Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart fail- ure显示文摘 | Jose CA Juana CG Francesc F | 2013 | Cardiology Journal2013，20，5： | 1 |
| 9 | Determination of macrolide antibiotics in meat and fish using pressurized liquid extraction and liquid chromatography-mass spectrometry 显示文摘 | HOUDA B FRANCESC B GUILLERMINA F | 2008 | J Chromatogr: A2008，1208，12： | 1 |
| 10 | Distance-based relevance feedback using a hybrid interactive genetic algorithm for image retrieval 显示文摘 | MIGUEL A H FRANCESC J F SALVADOR M P | 2011 | Applied Soft Computing2011，11，2： | 1 |
| 11 | Intrauterine growth restriction:new concepts in antenatal surveillance, diagnosis, and management显示文摘 | Francesc F Jason G | 2011 | Am J Obstet Gynecol2011，204，4： | 1 |
| 12 | On-line coupling of solid-phase extraction and capil- lary eleetrophoresis for the determination of cefoperazone and ceftiofur in plasma显示文摘 | Patricia Puig F W Alexander Tempels Francesc Borrull | 2007 | Journal of Chromatography B2007，856，12： | 1 |
| 13 | Determination of Macrolide Antibiotics in Meat and Fish using Pressurized Liquid Extraction and Liquid Chromatography - mass Spectrometry 显示文摘 | Houda B Francesc B Guillermina F | 2008 | Journal of Chromatography A2008，1208，： | 1 |
| 14 | Another move toward the minimum consistent subset:a tabu search approach to the condensed nearest neighbor rule显示文摘 | VICENTE C FRANCESC J F | 2001 | IEEE Transactions on Systems Man and Cybernetics-part B:Cybernetics2001，31，3： | 1 |
| 15 | Determination of Fenhexamid Residues in Grape Must, Kiwifruit, and Strawberry Samples by Enzyme-linked Immunosorbent Assay显示文摘 | FRANCESC A ESTEVE T ANTONIO A F | 2011 | Food Chemistry2011，124，： | 1 |
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