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| 1 | AHA/ASA关于卒中和短暂性脑缺血发作患者卒中预防推荐的更新显示文摘在卒中和短暂性脑缺血发作(transient ischemic attack,TIA)患者卒中预防推荐发表以后,美国心脏协会和美国卒中协会(American Heart Association/American Stroke Association,AHA/ASA)著述委员会对最近的一些试验结果进行了回顾。本文的目的是对这些新资料做简要回顾、更新某些推荐意见并说明进行这些修改的理由。在2个领域已发表了一些新的重要临床试验结果:(1)在非心源性栓塞所致缺血性卒中或TIA患者卒中二级预防中具体抗血小板药的应用;(2)他汀类药物在预防卒中复发中的应用。 | Robert J. Adams Greg Albers Mark J. Alberts Oscar Benavente Karen Furie Larry B. Goldstein Philip Gorelick Jonathan Halperin Robert Harbaugh S. Claiborne Johnston Irene Katzan Margaret Kelly-Hayes Edgar J. Kenton Michael Marks Ralph L. Sacco Lee H. Schwamm 赵洪芹 李海峰 (译) | 2008 | 国际脑血管病杂志2008,16,4: | 123 |
| 2 | 卒中或短暂性脑缺血发作患者的卒中预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南显示文摘本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐,包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外,还对其他许多特殊情况下的复发性卒中预防提供了推荐意见,包括动脉夹层分离、卯圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中(尤其是与妊娠和绝经后雌激素替代治疗相关性卒中)、脑出血后抗凝药的使用等,以及实施本指南及其在高危人群中应用的特定方法。 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia Wassertheil-Smoller Tanya N. Turan Deidre Wentworth 李海峰(译) 刘涛(译) 杨潘(译) 王鹏(译) | 2011 | 国际脑血管病杂志2011,19,1: | 391 |
| 3 | Effects of Slope Aspects on Soil Bacterial and Arbuscular Fungal Communities in a Boreal Forest in China显示文摘在 forested 环境的土壤 biogeochemical 性质和植物社区上的斜坡方面的效果广泛地被学习了;然而,倾斜对的方面影响大部分玷污微生物引起的社区遗体 unexamined,尽管有在生态系统工作的土壤生物区系的中央角色。在这研究,土壤细菌和 arbuscular mycorrhizal 真菌(AMF ) 的社区在更大的 Khingan 山的一个北方的森林里为斜坡方面(面对南方的方面,面对北方的方面和扁平的区域) 的三种类型用标注 pyrosequencing 被调查,中国。细菌并且 AMF 社区作文与斜坡方面不同。细菌的差异在面对北方的方面上是最低的,并且 AMF 差异在扁平的区域上是最低的。方面也在土壤 pH 和可得到的磷(P) 和灌木状的生物资源上有重要影响。土壤 pH 和 understory 灌木生物资源显著地与细菌的社区被相关,并且玷污可得到的 P 和灌木生物资源与 AMF 社区的显示出的重要关联。我们的结果建议了那个斜坡细菌的影响的方面和 AMF 社区,在植物社区和土壤化学药品性质由导致方面的变化调停了(例如, pH 和可得到的 P ) ,它在森林斜坡方面的效果上改进了知识在上未葬、地下社区。 | CHU Haiyan XIANG Xingjia YANG Jian Jonathan M. ADAMS ZHANG Kaoping LI Yuntao SHI Yu | 2016 | Pedosphere2016,26,2: | 15 |
| 4 | Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia W | 2011 | Stroke2011,,1: | 8 |
| 5 | 英国国际合作格局显示文摘该报告运用文献计量学方法,对英国及其主要合作伙伴国的国际合作格局做了全面的分析。所选择的主要国家包括美国、加拿大、法国、德国、日本、澳大利亚、中国与印度;数据覆盖领域有临床、医药卫生、生物科学、环境科学、数学、物质科学以及工程技术领域;数据时间分为1996—2000年与2001—2005年两个时间段。结果显示:国际论文数量增长显著;英国国际合作论文份额的增长比 G7国家更加快速;德国和美国是英国最大的国际合作伙伴;英国国际合作论文的平均影响力显著高于其科研论文的总体影响力;中国与英国合作发表的论文数量超过了与其他欧洲各国的合作论文数。 | Jonathan Adams Karen Gurney Stuart Marshall 朱海洋 | 2007 | 科学观察2007,2,6: | 8 |
| 6 | 全面画像 而非简单指标显示文摘本报告强调:当有关科研人员及其机构的数据被压缩为简单的指标和排名时,有些信息将会遗失。本报告阐述了四类常见分析,如若误用将掩盖真实的科研表现;我们提出了四种可视化选项,用于解读每个度量指标下蕴含的更丰富的信息,以支持开展全面的、负责任的科研管理。我们身边依然存在着声称可通过简单分析来评估论文、科研人员和机构表现的现象。 | Jonathan Adams Marie McVeigh David Pendlebury Martin Szomszor | 2019 | 科学观察2019,14,4: | 6 |
| 7 | 多作者署名与研究分析显示文摘Web of Science中不断涌现出拥有1000个、甚至更多作者,横跨100多个国家的研究论文。众多作者/众多国家的组合产生出复杂的作者署名模式,它不同于传统的典型学术论文,而且推升了论文引用率。在该报告中,我们将描述两种模式,它们将复杂作者署名与引用率提升效应关联在一起:与多作者署名(超过10个作者,5个以上国家)相关的普遍性引用率提升;超大规模作者署名(超过100个作者,超过30个国家)导致的更具扰动性的结果. | Jonathan Adams David Pendlebury Ross Potter Martin Szomszor | 2020 | 科学观察2020,15,4: | 4 |
| 8 | Pakl mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression显示文摘 | Kejing Zeng Lili Tian Adam Sirek Weijuan Shao Ling Liu Yu-Ting Chiang Jonathan Chernoff Dominic S. Ng Jianping Weng Tianru Jin | 2017 | Journal of Molecular Cell Biology2017,9,5: | 4 |
| 9 | 缺血性卒中或短暂性脑缺血发作患者的卒中预防指南显示文摘这份新声明旨在为缺血性卒中或短暂性脑缺血发作存活者的缺血性卒中预防提供全面和及时的循证推荐,循证推荐包括对危险因素的控制,动脉粥样硬化性疾病的干预措施,心源性栓塞的抗栓治疗以及非心源性卒中抗血小板药的应用。另外,还为其他多种特殊情况下复发性卒中的预防提供了推荐、包括动脉夹层分离、卵圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中(特别是与妊娠和绝经后激素替代治疗相关卒中),脑出血后肮凝药的应用,以及该指南在高危人群中执行和应用的特殊措施。 | Ralph L.Sacco Robert Adams Grge Albers Mark J.ALBERTS Oscar Benavente Karen Furie Larry B.Goldstein Philip Gorelick Jonathan Halperin Robert Harbaugh S.Claiborne Johnston Irene Katzan Margaret Kelly-Hayes Edgar J.Kenton Michael Marks Lee H.Schwamm Thomas Tomsick 曹勇军(译) 陈孝东(译) 毛成洁(译) 刘春风(译) | 2006 | 中华脑血管病论坛2006,4,1: | 3 |
| 10 | 2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy显示文摘An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfortunately,current iron-based therapeutic strategies often lack effectiveness and can elicit off-target toxicities.We report here a dual-therapeutic prodrug,DOXjade,that allows for iron chelation chemo-photothermal cancer therapy.This prodrug takes advantage of the clinically approved iron chelator deferasirox(ExJade®)and the topoisomerase 2 inhibitor,doxorubicin(DOX).Loading DOXjade onto ultrathin 2D Ti_(3)C_(2) MXene nanosheets produces a construct,Ti_(3)C_(2)-PVP@DOXjade,that allows the iron chelation and chemotherapeutic functions of DOXjade to be photo-activated at the tumor sites,while potentiating a robust photothermal effect with photothermal conversion efficiencies of up to 40%.Antitumor mechanistic investigations reveal that upon activation,Ti_(3)C_(2)-PVP@DOXjade serves to promote apoptotic cell death and downregulate the iron depletion-induced iron transferrin receptor(TfR).A tumor pH-responsive iron chelation/photothermal/chemotherapy antitumor effect was achieved both in vitro and in vivo.The results of this study highlight what may constitute a promising iron chelation-based phototherapeutic approach to cancer therapy. | Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim | 2022 | Bioactive Materials2022,7,8: | 2 |
| 11 | 走向强盛的金砖国家(BRICKS) 巴西、俄罗斯、印度、中国和韩国科研与创新全球影响力解析显示文摘1概述40年前,全球的科学研究版图放眼望去是分布在令人激动但却相对单一的地区。尽管重要的科学发现不计其数,但是大多却来自经济发达的欧洲和北美。在汤森路透Web of | Jonathan Adams David Pendlebury Bob Stembridge 朱海峰 马建华 | 2013 | 科学观察2013,8,2: | 2 |
| 12 | Role of homocysteine in aortic calcification and osteogenic cell differentiation显示文摘 | Ann Van Campenhout Corey S. Moran Adam Parr Paula Clancy Catherine Rush Hieronim Jakubowski Jonathan Golledge | 2008 | Atherosclerosis2008,,2: | 2 |
| 13 | 科学新格局:英国科研及其国际合作显示文摘国际合作研究不仅可以利用其他国家的科研投资,而且能够产生具有轰动效应的创新型结果。由于语言文化的相似性,英国与美国及欧洲国家有着较为广泛的联系,他们之间的合作是英国科学研究合作的主体。随着科学研究及技术革新的发展更多地转向东方,以及中国和印度这两大科技力量的迅猛发展,英国应该更加重视与这两个国家的合作。文章指出:应该就英国及其新伙伴之间的关系进行详细的研究,从而深入理解中英两国间的合作并建立成功的合作模式。 | Jonathan Adams James Wilsdon 朱海峰(翻译) | 2007 | 科学观察2007,2,5: | 2 |
| 14 | The Relative Effect of Azone? and Transcutol? on Permeant Diffusivity and Solubility in Human Stratum Corneum显示文摘 | Julian E. Harrison Adam C. Watkinson Darren M. Green Jonathan Hadgraft Keith Brain | 1996 | Pharmaceutical Research1996,,4: | 2 |
| 15 | Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Karen L. Furie Scott E. Kasner Robert J. Adams Gregory W. Albers Ruth L. Bush Susan C. Fagan Jonathan L. Halperin S. Claiborne Johnston Irene Katzan Walter N. Kernan Pamela H. Mitchell Bruce Ovbiagele Yuko Y. Palesch Ralph L. Sacco Lee H. Schwamm Sylvia W | 2011 | Stroke2011,,1: | 2 |
| 16 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008,,4: | 2 |
| 17 | UNDERSTANDING THE MECHANICAL PROPERTIES OF SINGLE MICRO-PARTICLES AND THEIR COMPACTION BEHAVIOUR显示文摘The compaction of particulate materials to form tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. The general aim of the current study is to understand the relationship between the mechanical properties of single feed particles (< 100 μm) and their compaction behaviour in order to produce tablets at low compression pressure with acceptable strength. The materials studied were pharmaceutical excipients, comprising three enteric polymer particles and three different powders in the form of agglomerates. The mechanical properties of the individual particles or agglomerates were determined by a micromanipulation technique. The samples were also com- pacted in cylindrical tableting dies. It was observed that there was a strong correlation between the forces required to cause the fracture of the single particles and those derived from the compaction measurements as determined using an existing analysis. | Siaw Fung Yap Michael Adams Jonathan Seville Zhibing Zhang | 2006 | China Particuology2006,4,1: | 2 |
| 18 | Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression显示文摘 | Lei S. Qi Matthew H. Larson Luke A. Gilbert Jennifer A. Doudna Jonathan S. Weissman Adam P. Arkin Wendell A. Lim | 2013 | Cell2013,,: | 2 |
| 19 | Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression显示文摘 | Lei S. Qi Matthew H. Larson Luke A. Gilbert Jennifer A. Doudna Jonathan S. Weissman Adam P. Arkin Wendell A. Lim | 2013 | Cell2013,,: | 2 |
| 20 | Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) on the use of endoscopy simulators for training and assessing skill显示文摘 | Jonathan Cohen Brian P. Bosworth Amitabh Chak Brian J. Dunkin Dayna S. Early Lauren B. Gerson Robert H. Hawes Adam V. Haycock Juergen H. Hochberger Joo Ha Hwang John A. Martin Peter R. McNally Robert E. Sedlack Melina C. Vassiliou | 2012 | Gastrointestinal Endoscopy2012,,3: | 1 |