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| 1 | DOCK8 regulates signal transduction events to control immunity显示文摘在编码 DOCK8 的基因的基因变化引起亢奋的免疫球蛋白 E 症候群(AR 催促) 的一种正染色体的后退的形式,是指了 DOCK8 缺乏。在人的 DOCK8 缺乏导致联合免疫不全疾病(首领) 的发作,临床上与多样的微生物引起的病原体,和倾向与长期的感染联系了到恶意。DOCK8 调整多样的有免疫力的房间子类型的功能,现在正在变得清楚,特别地淋巴细胞,驾驶天生、适应的有免疫力的回答。早研究证明 DOCK8 为淋巴细胞幸存,移植和有免疫力的触处形成被要求,它当 DOCK8 不在时翻译到差的病原体控制。然而,更最近的进展在调整控制 transcriptional 活动, cytokine 生产和有免疫力的房间的功能的极化的信号 transduction 事件为 DOCK8 指向了一个关键角色。这里,我们在我们 DOCK8 功能的理解总结最近的进展,对象把有免疫力的回答提升到多样的外部刺激的发信号的中介的一个新兴的角色给予特别注意。 | Conor J Kearney Katrina L Randall Jane Oliaro | 2017 | Cellular & Molecular Immunology2017，14，5： | 5 |
| 2 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 5 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | The Lancet . 2009 (9702)2009，，： | 2 |
| 6 | Biliary atresia显示文摘 | Jane L Hartley Mark Davenport Deirdre A Kelly | 2009 | 2009 (9702)2009，，9702： | 2 |
| 7 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 8 | Ceil contact as an independent factor moduletating cardiac myocytes hypertrophy and survival in long-term primary culture显示文摘 | Clark W A Decker M L Janes D M | 1998 | J Mol Cell Cardiol1998，30，： | 1 |
| 9 | Oxidative risk for atherothrom- botic cardiovascular disease 显示文摘 | Jane AL Joseph L | 2009 | Free Radic Biol Med2009，47，12： | 1 |
| 10 | Changes oflipid composition and saturation level in leaves and rootsfor heat-stressed and heat-acclimated creeping bent-grass显示文摘 | JANE L A RKINDA L E HUANG B R | 2004 | Environmental and Experimental Botany2004，51，： | 1 |
| 11 | Molecular weights and gyration radii of amylopectins determined by high-performance size-ex- clusion chromatography equipped with multi-angle laser- light scattering and refractive index detectors 显示文摘 | Yoo S H Jane J L | 2002 | Car- bohydrate Polymers2002，49，3： | 1 |
| 12 | Regulatory challenges for new drugs to treat obesity and eomorbid metabolic disorders 显示文摘 | David J H Jane G Sharon L S | 2009 | Br J ClinPharmaeol2009，68，6： | 1 |
| 13 | Characterization of SU1 isoamylase,a determinant of storage starch structure in maize显示文摘 | Wong K S Jane J L Myers A M James M G | 1998 | Plant physiology1998，117，： | 1 |
| 14 | Developmental changes in enzymes of flavouoid biosynthesis in the skins of red and green apple cultivators 显示文摘 | Carolyn E L Jane E L John R L | 1996 | Sei Food Agric1996，71，： | 1 |
| 15 | High-accuracy Analog Measurements Via Interpolated FFT显示文摘 | Jane V K Collins W L Jr Davis D C | 1979 | IEEE Trans-M1979，28，2： | 1 |
| 16 | Preparation and properties of small-particle corn starch 显示文摘 | Jane J Shen L Wang L | 1992 | Cereal Chemistry1992，69，3： | 1 |
| 17 | Using QuickTime Virtual Reality Objects in Computer-assisted Instruction of Gross Anatomy:Yorick-the VR Skull显示文摘 | Gary L Nieder Jane N Scott | 2000 | Clinical Anatomy2000，13，4： | 1 |
| 18 | Effects of lipids on enzymatic hydrolysis and physical properties of starch 显示文摘 | Ai Y F Hasjim J Jane J L | 2013 | Carbo- hydrate Polymers2013，92，1： | 1 |
| 19 | Ectopic expression of bac- terial amylopullulanase enhances bioethanol production from maize grain显示文摘 | Nahampun H N Lee C J Jane J L | 2013 | Plant Cell Rep2013，32，9： | 1 |
| 20 | 显示文摘 | Xiao L Zhang H Jane T | 2005 | Fuel Cells2005，5，4： | 1 |
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