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| 1 | 南海红树林内生真菌1356#代谢产物的研究显示文摘从南海红树林内生真菌1356#分离出两种鞘胺醇(A,B)和三种环二肽(C,D,E)?它们的结构通过IR,MS,1D NMR和2D NMR谱推导出来?(3'E,4E)-1-(-D-吡喃葡萄糖基-3-羟基-2-(2'-羟基十八碳酰基)氨基-10-甲基-3',4,9-十八碳三烯(A)是一种新的鞘胺醇甙? | 吴雄宇 林永成 冯爽 姜广策 周世宁 Vrijmoed L L P Jones E B G | 2001 | 热带海洋学报2001，20，4： | 17 |
| 2 | Spectrum of anemia associated with chronic liver disease显示文摘Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological complications of combination therapy for chronic viral hepatitis include clinically signif icant anemia, secondary to treatment with ribavirin and/or interferon. Ribavirininduced hemolysis can be reversed by reducing the dose of the drug or discontinuing it altogether. Interferons may contribute to anemia by inducing bone marrow suppression. Alcohol ingestion is implicated in the pathogenesis of chronic liver disease and may contribute to associated anemia. In patients with chronic liver disease, anemia may be exacerbated by defi ciency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption. | Rosario Gonzalez-Casas E Anthony Jones Ricardo Moreno-Otero | 2009 | World Journal of Gastroenterology2009，15，37： | 13 |
| 3 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 4 | Liver disease and erythropoietic protoporphyria:A concise review显示文摘The porphyries are a group of metabolic disorders characterized by deficiencies in the activity of enzymes involved in the biosynthesis of heme.In erythropoietic protoporphyria(EPP),in the majority of cases an autosomal dominant disease,there is a mutation of the gene that encodes ferrochelatase(FECH).FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes,plasma,skin and liver.The prevalence of this inherited disorder oscillates between 1:75 000 and 1:200 000.Clinical manifestations of EPP appear in early infancy upon first exposure to the sun.Nevertheless,approximately 5%-20% of patients with EPP develop liver manifestations.Retention of protoporphyrin in the liver is associated with cholestatic phenomena and oxidative stress that predisposes to hepatobiliary disease of varying degrees of severity,such as cholelithiasis,mild parenchymal liver disease,progressive hepatocellular disease with end-stage liver disease and acute liver failure.Liver damage is the major risk in EPP patients,so surveillance and frequent clinical and biochemical liver follow-up is mandatory.The diagnostic approach consists in detecting increased levels of protoporphyrin,decreased activity of FECH and genetic analysis of the FECH gene.A variety of nonsurgical therapeutic approaches have been adopted for the management of EPP associated with liver disease,but none of these has been shown to be unequivocally efficacious.Nevertheless,some may have a place in preparing patients for liver transplantation.Liver transplantation does not correct the constitutional deficiency of FECH.Consequently,there is a risk of recurrence of liver disease after liver transplantation as a result of continuing overproduction of protoporphyrin.Some authors recommend that bone marrow transplantation should be considered in liver allograft recipients to prevent recurrence of hepatic disease. | María José Casanova-González María Trapero-Marugán E Anthony Jones Ricardo Moreno-Otero | 2010 | World Journal of Gastroenterology2010，16，36： | 7 |
| 5 | 水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。 | Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka | 2007 | 国外测井技术2007，22，4： | 7 |
| 6 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 7 | Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease显示文摘AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson's disease. METHODS: Twenty-one subjects(13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson's disease(Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq 99mTc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose byglucometer for 180 min. Autonomic nerve function was evaluated with cardiovascular reflex tests and upper gastrointestinal symptoms by questionnaire. RESULTS: The mean gastric half-emptying time was 106 ± 9.1 min, gastric emptying was abnormally delayed in 3 subjects(14%). Systolic and diastolic blood pressure fell(P < 0.001) and mesenteric blood flow and blood glucose(P < 0.001 for both) increased, following the drink. Three subjects(14%) had definite autonomic neuropathy and 8(38%) had postprandial hypotension. There were no significant relationships between changes in blood pressure, heart rate or mesenteric artery blood flow with gastric emptying. Gastric emptying was related to the score for autonomic nerve function(R = 0.55, P < 0.01). There was an inverse relationship between the blood glucose at t = 30 min(R =-0.52, P < 0.05), while the blood glucose at t = 180 min was related directly(R = 0.49, P < 0.05), with gastric emptying. CONCLUSION: In mild to moderate Parkinson's disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose. | Laurence G Trahair Thomas E Kimber Katerina Flabouris Michael Horowitz Karen L Jones | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 8 | Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间表示一连串的激活受体在早怀孕期间调整胎盘的免疫和开发。我们在在 dNK 和 trophoblast 房间之间的怀孕期和相互作用的第一和第二个三个月期间调查了人的 dNK 房间的功能的特性。尽管 CD56 + 在全部的 CD45 + 白血球之中的 CD16 − dNK 没在这个句号,激活的受体的表示, NKp80 和 NKG2D 上变化,极大地 upregulated。我们与第二三个月蜕膜比较在第一个三个月在最近观察了 extravillous trophoblast 房间的一个显著地更高的数字到 dNK 房间。当 co 有教养时,由第一个三个月 dNK 房间的 NKG2D 表示与 HTR-8 trophoblast 房间线被减少。在第二个三个月, dNK 激活的功能的标记,即, angiogenic 因素生产(例如,脉管的 endothelial 生长因素, interleukin-8, interferon-gamma ) ,尽管有 NKp80 或 NKG2D 表面表示的增加的仍然是的马厩。而且, dNK 房间的 degranulation 能力由 CD107a 估计了在第二个三个月被减少。我们建议在第一个三个月, trophoblast-dNK 相互作用与压制的激活的显型产生 dNK 房间的一张人口。在第二个三个月, trophoblast-dNK 相互作用的损失导致了 dNK 房间功能的抑制,尽管他们的激活的受体表示被增加。我们推测在怀孕期间,二机制操作调制激活受体的 dNK 房间 activation:suppression,这由在第二个三个月联合的 receptor-ligand 的 trophoblasts 和解开在第一个三个月铺平。 | Jianhong Zhang Caroline E Dunk Melissa Kwan Rebecca L Jones Lynda K Harris Sarah Keating Stephen J Lye | 2017 | Cellular & Molecular Immunology2017，14，2： | 4 |
| 9 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 10 | Wrist Fractures显示文摘 | Douglas P Hanel Marci D Jones Thomas E Trumble | 2002 | Orthopedic Clinics of North America2002，，1： | 3 |
| 11 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 12 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 13 | Transgenic Caenorhabditis elegans strains as biosensors显示文摘 | Candido E P Jones D | 1996 | Trends in Biochemistry1996，14，： | 2 |
| 14 | Continuous venovenous high-flux dialysis in multiorgan failure: a 5-year single center experience 显示文摘 | Jones CH Richardson D Goutcher E | 1998 | Am J Kidney Dis1998，31，： | 2 |
| 15 | Domiciliary nocturnal intermittent p o sitive pressure ventilation in patients with respiratory failure due to severe C OPD:long term follow up and effect on survival显示文摘 | Jones S E Packham S Hebden M | 1998 | Thorax1998，53，： | 2 |
| 16 | Plant disease resistance genes显示文摘 | Hammond-Kosack K E Jone J D | 1997 | Annu Rev Plant Physiol Plant Mol Biol1997，48，： | 2 |
| 17 | Hydrotherapy Versus Conventional Land-Based Exercise for the Management of Patients With Osteoarthritis of the Knee: A Randomized Clinical Trial显示文摘 | Silva Luciana E Valim Valeria Pessanha Ana Paula C Oliveira Leda M Myamoto Samira Jones Anamaria Natour Jamil | 2008 | Physical Therapy2008，，1： | 2 |
| 18 | 制药企业药品上市前安全风险管理显示文摘1药物警戒的必要性良好的药物警戒是最理想的药品风险管理方式,它可以最大程度的了解某种药品的所有信息,并且发现它潜在的安全问题,甚至有可能发现其预料之外的好处。鉴于这个理念,新化学实体(newchemical entity)在研发初期就必须进行动物和人体安全性测试,以便更好地促进并保护公众健康。中国古话所说的"是药三分毒", | Judith K Jones Elyse E Kingery Jing Tao Jeff J Guo | 2013 | 药物流行病学杂志2013，22，5： | 2 |
| 19 | Switching barriers and repurchase intentions in services显示文摘 | Michael A Jones David L Mothersbaugh Sharon E Beatty | 2000 | Journal of Retailing2000，，2： | 2 |
| 20 | The diffusion of zinc in cadmium telluride 显示文摘 | ASLAM N JONES E NOAKES T Q | 1992 | J Cryst Growth1992，117，： | 2 |
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