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| 1 | Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity显示文摘Cereal crops and cereal consumption have had a vital role in Mankind's history. In the recent years gluten ingestion has been linked with a range of clinical disorders. Gluten-related disorders have gradually emerged as an epidemiologically relevant phenomenon with an estimated global prevalence around 5%. Celiac disease, wheat allergy and non-celiac gluten sensitivity represent different gluten-related disorders. Similar clinical manifestations can be observed in these disorders, yet there are peculiar pathogenetic pathways involved in their development. Celiac disease and wheat allergy have been extensively studied, while non-celiac gluten sensitivity is a relatively novel clinical entity, believed to be closely related to other gastrointestinal functional syndromes. The diagnosis of celiac disease and wheat allergy is based on a combination of findings from the patient's clinical history and specific tests, including serology and duodenal biopsies in case of celiac disease, or laboratory and functional assays for wheat allergy. On the other hand, non-celiac gluten sensitivity is still mainly a diagnosis of exclusion, in the absence of clear-cut diagnostic criteria. A multimodal pragmatic approach combining findings from the clinical history, symptoms, serological and histological tests is required in order to reach an accurate diagnosis. A thorough knowledge of the differences and overlap in clinical presentation among gluten-related disorders, and between them and other gastrointestinal disorders, will help clinicians in the process of differential diagnosis. | Luca Elli Federica Branchi Carolina Tomba Danilo Villalta Lorenzo Norsa Francesca Ferretti Leda Roncoroni Maria Teresa Bardella | 2015 | World Journal of Gastroenterology2015，21，23： | 8 |
| 2 | Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model显示文摘AIM: To evaluate the interplay between gliadin and LoVo cells and the direct effect of gliadin on cytoskeletal patterns.METHODS: We treated LoVo multicellular spheroids with digested bread wheat gliadin in order to investigate their morphology and ultrastructure (by means of light microscopy and scanning electron microscopy), and the effect of gliadin on actin (phalloidin fluorescence)and the tight-junction protein occludin and zonula occluden-1.RESULTS: The treated spheroids had deep holes and surface blebs, whereas the controls were smoothly surfaced ovoids. The incubation of LoVo spheroids with gliadin decreased the number of intracellular actin filaments, impaired and disassembled the integrity of the tight-junction system.CONCLUSION: Our data obtained from an 'in vivolike' polarized culture system confirm the direct noxious effect of gliadin on the cytoskeleton and tight junctions of epithelial cells. Unlike two-dimensional cell culture systems, the use of multicellular spheroids seems to provide a suitable model for studying cell-cell interactions. | Ersilia Dolfini Leda Roncoroni Luca Elli Chiara Fumagalli Roberto Colombo Simona Ramponi Fabio Forlani Maria Teresa Bardella | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 3 | Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease显示文摘 | Edward M. Kennedy Leda C. Bassit Henrik Mueller Anand V.R. Kornepati Hal P. Bogerd Ting Nie Payel Chatterjee Hassan Javanbakht Raymond F. Schinazi Bryan R. Cullen | 2014 | Virology2014，，： | 3 |
| 4 | Hydrotherapy Versus Conventional Land-Based Exercise for the Management of Patients With Osteoarthritis of the Knee: A Randomized Clinical Trial显示文摘 | Silva Luciana E Valim Valeria Pessanha Ana Paula C Oliveira Leda M Myamoto Samira Jones Anamaria Natour Jamil | 2008 | Physical Therapy2008，，1： | 2 |
| 5 | Platelet biomarkers in Alzheimer's disease显示文摘The search for diagnostic and prognostic markers in Alzheimer's disease(AD) has been an area of active research in the last decades. Biochemical markers are correlates of intracerebral changes that can be identified in biological fluids, namely: peripheral blood(total blood, red and white blood cells, platelets, plasma and serum), saliva, urine and cerebrospinal fluid. An important feature of a biomarker is that it can be measured objectively and evaluated as(1) an indicator of disease mechanisms(markers of core pathogenic processes or the expression of downstream effects of these processes), or(2) biochemical responses to pharmacological or therapeutic intervention, which can be indicative of disease modification. Platelets have been used in neuropharmacological models since the mid-fifties, as they share several homeostatic functions with neurons, such as accumulation and release of neurotransmitters, responsiveness to variations in calcium concentration, and expression of membrane-bound compounds. Recent studies have shown that platelets also express several components related to the pathogenesis of AD,in particular to the amyloid cascade and the regulation of oxidative stress: thus they can be used in the search for biomarkers of the disease process. For instance, platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B. Moreover, platelets express enzymes involved in membrane homeostasis(e.g., phospholipase A2), and markers of the inflammatory process and oxidative stress. In this review we summarize the available literature and discuss evidence concerning the potential use of platelet markers in AD. | Leda L Talib Helena PG Joaquim Orestes V Forlenza | 2012 | World Journal of Psychiatry2012，2，6： | 2 |
| 6 | New technology and the modeling of risk-taking behavior in congested road networks显示文摘 | YIN Y LAM W H K lEDA H | 2004 | Transportation Research Part C2004，12，34： | 1 |
| 7 | Thermoresponsive hydrogels in biomedical applications显示文摘 | Leda Klouda Antonios G. Mikos | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，，1： | 1 |
| 8 | Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus 显示文摘 | Leda SBG Clarissa MC Samira SV | 2008 | Prog Neuro-Psychopharmacol Biol Psychiatry2008，32，1： | 1 |
| 9 | Structure and magnetic properties of the two-dimensional ferrimagnet (NEt4):investigation of magnetic anisotropy on a single crystal显示文摘 | MIYASAKA H LEDA H MATSUMOTO N | 2003 | Inorg Chem2003，42，： | 1 |
| 10 | Effect of chlorine on filamentous microorganisms present in activated sludge as evaluated by respirometry and INT-dehydrogenase activity显示文摘 | Alejandro Caravelli Leda Giarmuzzi Noemi Zaritzky | 2004 | Water Research2004，，： | 1 |
| 11 | Thermoresponsive hydrogels in biomedical applications显示文摘 | Leda Klouda Antonios G. Mikos | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，，1： | 1 |
| 12 | Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats显示文摘 | Leda S B Garcia Clariss M Comim Samira S Valvassori | | 0，，03： | 1 |
| 13 | Stratcgic Human Resource Management and its cffets on firm performance: an implementation of the competing values framework 显示文摘 | Leda Panayotopoulou Dimitris Bourantas and Nancy Papalcxandris | 2003 | International Journal of Human Resource Management2003，2003，： | 1 |
| 14 | IL-6 Knock-Out Mice Show Modified Basal Immune Functions, but Normal Immune Responses to Stress 显示文摘 | Barbara M Paola S Leda G | 1998 | Brain Behav Immun1998，12，： | 1 |
| 15 | A systematic methodology for the environomic design and synthesis of energy systems combining Process Integration, Life Cycle Assessment and Industrial Ecology 显示文摘 | LEDA GERBER SAMIRA FAZLOLLAHI FRANGOIS MARECHAL | 2013 | Computers & Chemical Engineering2013，59，： | 1 |
| 16 | Thermoresponsive hydrogels in biomedical applications显示文摘 | Leda Klouda Antonios G. Mikos | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，，1： | 1 |
| 17 | Factors associated with cognitive impairment in elderly patients with diabetes melitus 显示文摘 | N Suzuki H Umegaki S Leda | 2006 | J Am Geriatr Soc2006，54，3： | 1 |
| 18 | IL-6 Knock-Out Mice Show Modified Basal Immune Functions,but Normal Immune Responses to Stress显示文摘 | Barbara Manfredi Paola Sacerdote Leda Gaspani | 1998 | BRAIN BEHAVIOR AND IMMUNITY1998，12，： | 1 |
| 19 | Rheological Properties of Tin Oxide Suspensions显示文摘 | Leda Maria Garcia dos Santosd Antonio Gouveia de Souzab Fabrcio Ronil Sensatoa | 2002 | Journal of the European Ceramic Society2002，22，： | 1 |
| 20 | Evidence for a fourth locus for autosomal dominant nnctumal front lobe epilepsy 显示文摘 | Romina C Leda D Massimo M | 2004 | Brain Res Bulletin2004，63，： | 1 |
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