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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Acousto-optical modulation of thin film lithium niobate waveguide devices显示文摘Due to its strong piezoelectric effect and photo-elastic property, lithium niobate is widely used for acousto-optical applications. However, conventional bulk lithium niobate waveguide devices exhibit a large footprint and limited light–sound interaction resulting from the weak guiding of light. Here, we report the first acousto-optical modulators with surface acoustic wave generation, phononic cavity, and low-loss photonic waveguide devices monolithically integrated on a 500 nm thick film of lithium niobate on an insulator. Modulation efficiency was optimized by properly arranging the propagation directions of surface acoustic waves and optical guided modes.The effective photo-elastic coefficient extracted by comparing the first and third harmonic modulation signals from an on-chip Mach–Zehnder interferometer indicates the excellent acousto-optical properties of lithium niobate are preserved in the thin film implementation. Such material property finding is of crucial importance in designing various types of acousto-optical devices. Much stronger amplitude modulation was achieved in a high Q(>300,000) optical resonator due to the higher optical sensitivity. Our results pave the path for developing novel acousto-optical devices using thin film lithium niobate. | LUTONG CAI ASHRAF MAHMOUD MSI KHAN MOHAMED MAHMOUD TAMAL MUKHERJEE JAMES BAIN GIANLUCA PIAZZA | 2019 | Photonics Research2019，7，9： | 5 |
| 3 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 4 | Locally transplanted enteric glia improve functional and structural recovery in a rat model of spinal cord injury显示文摘<正>BACKGROUND:We have previously reported that adult enteric glia(EG) facilitate the growth of transected dorsal root axons into the uninjured spinal cord to form functional connections with their targets. OBJECTIVE:The present study investigated the effects of EG on spinal cord function,tissue injury, and axonal regeneration following transplantation into injured rat spinal cords,according to histological and functional outcomes. DESIGN,TIME AND SETTING:A randomized controlled animal experiment was performed at McMaster University,Canada from January 2006 to March 2008. MATERIALS:EG were isolated from rat intestine. METHODS:One week following spinal cord crush,female Wistar rats were injected with an EG suspension(2μL,1×10~5/μL,n=10) or with the same volume of fresh culture medium alone(control animals,n=11).The third group did not receive any injection following laminectomy and served as the sham-operated controls(n=5). MAIN OUTCOME MEASURES:Behavior was tested prior to transplantation and weekly following transplantation,with nine behavioral examinations in total.Open field,hind limb placement response, foot orientation response,and inclined plane test were utilized.Immediately following the final behavioral examination,spinal cord T_9 to L_1 segments were harvested for immunohistochemical and hematoxylin-eosin staining to determine astroglial scarring,axonal regeneration and spinal cord lesion size. RESULTS:Rats with EG transplantation exhibited significantly better locomotor function with reduced tissue damage,compared with the control rats.Cystic cavities were present 2 months after injury in spinal cords from both control groups.In contrast,rats injected with EG did not present with cystic lesions.In addition,the injury site consisted of cellular material and nerve fibers,and axonal regeneration was apparent,with dense labeling of neurofilament-positive axons within the injury site. Moreover,regenerating axons were intimately associated with transplanted EG CONCLUSION:These data indicated that EG enhanced functional improvement,which was associated with reduced tissue damage and axonal regeneration following transplantation into injured spinal cords. | Shucui Jiang Mohammad I. Khan James R. Bain Cai Jiang Christopher R. Hansebout Zesheng Yu Yuqing Liu Michel P, Rathbone | 2009 | Neural Regeneration Research2009，4，9： | 2 |
| 5 | 显示文摘 | Abelmann Leon Zhu J G Bain James A | 2000 | J Appl Phys2000，87，9： | 1 |
| 6 | Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness显示文摘 | Bryan C. Batch Svati H. Shah Christopher B. Newgard Christy B. Turer Carol Haynes James R. Bain Michael Muehlbauer Mahesh J. Patel Robert D. Stevens Lawrence J. Appel L. Kristin Newby Laura P. Svetkey | 2013 | Metabolism2013，，7： | 1 |
| 7 | The Peripheral Nerve Allograft in the Primate Immunosuppressed with Cyclosporin A: I. Histologic and Electrophysiologic Assessment显示文摘 | James R. Bain Susan E. Mackinnon Alan R. Hudson Judy Wade Peter Evans Akira Makino Daniel Hunter | 1992 | Plastic and Reconstructive Surgery1992，，6： | 1 |
| 8 | Self-monitoring style and levels of interrogative suggestibility显示文摘 | Stella A Bain James S Baxter Katie Ballantyne | 2007 | Personality and Individual Differences2007，，4： | 1 |
| 9 | Combined thoracoscopic and laparoscopic robotic-assisted minimally invasive esophagectomy using a four-arm platform: experience, technique and cautions during early procedure development ? 显示文摘 | Inderpal S. Sarkaria Nabil P. Rizk David J. Finley Manjit S. Bains Prasad S. Adusumilli James Huang Valerie W. Rusch | 2013 | European Journal of Cardio-Thoracic Surgery2013，，5： | 1 |
| 10 | 显示文摘 | Li Zhang James A Bain Jian-Gang Zhu | 2002 | IEEE Trans Magn2002，38，： | 1 |
| 11 | Recovery of absolute gas absorption line shapes usingtunable diode laser spectroscopy with wavelength modu-lation-part I: Theoretical analysis 显示文摘 | Stewart George Johnstone Walter Bain James R P etal | 2011 | Journal of Light-wave Technology2011，29，6： | 1 |
| 12 | Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease显示文摘 | Plant Pamela J Brooks Dina Faughnan Marie Bayley Tanya Bain James Singer Lianne Correa Judy Pearce Dawn Binnie Matthew Batt Jane | 2010 | American Journal of Respiratory Cell and Molecular Biology2010，，4： | 1 |
| 13 | Five-year Analysis of Operative Mortality and Neonatal Outcomes in Congenital Heart Disease显示文摘 | James R. Padley Andrew D. Cole Victoria E. Pye Richard B. Chard Ian A. Nicholson Stephen Jacobe David Baines Nadia Badawi Karen Walker Gabbie Scarfe Karen Leclair Gary F. Sholler David S. Winlaw | 2011 | Heart, Lung and Circulation2011，，7： | 1 |
| 14 | Sirolimus‐based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma显示文摘 | Norman M. Kneteman José Oberholzer Mohammed Al Saghier Glenda A. Meeberg Maurice Blitz Mang M. Ma Winnie W.S. Wong Klaus Gutfreund Andrew L. Mason Larry D. Jewell A.M. James Shapiro Vincent G. Bain David L. Bigam | 2004 | Liver Transpl2004，，10： | 1 |
| 15 | Hamr adjacent track stability in the presence of a medium curie temperature distribution显示文摘 | Brian R Knight James A Bain Tuviah E Schlesinger | | 0，，06： | 1 |
| 16 | Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion显示文摘 | Aslan T. Turer Robert D. Stevens James R. Bain Michael J. Muehlbauer Johannes van der Westhuizen Joseph P. Mathew Debra A. Schwinn Donald D. Glower Christopher B. Newgard Mihai V. Podgoreanu | 2009 | Circulation2009，，13： | 1 |
| 17 | Use of Room-Temperature Bias Sputtering to Decrease Intergranular Coupling in Magnetic Media Deposited on Polymeric Substrates显示文摘 | Lee Hwan-Soo Wang Lin Bain James A | 1994 | IEEE Transactions on Magnetics1994，39，6： | 1 |
| 18 | De Novo Sirolimus-Based Immunosuppression After Liver Transplantation for Hepatocellular Carcinoma: Long-Term Outcomes and Side Effects显示文摘 | Christian Toso Glenda A. Meeberg David L. Bigam Jose Oberholzer A M. James Shapiro Klaus Gutfreund Mang M. Ma Andrew L. Mason Winnie W. S. Wong Vincent G. Bain Norman M. Kneteman | 2007 | Transplantation2007，，9： | 1 |
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