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| 1 | Antioxidant, antimicrobial and cytotoxic potential of condensed tannins from Leucaena leucocephala hybrid-Rendang显示文摘Condensed tannins(CTs)are one of the promising compounds due to their potentially health-promoting qualities.In this study,CTs were extracted from a Leucaena leucocephala hybrid-Rendang and subjected to various biological studies including antioxidant(using Ferric reducing antioxidant power(FRAP),DPPH and ABTS radical scavenging assay),anti-microbial(against different pathogens)and cytotoxic activities(toward human breast adenocarcinoma(MCF-7),human colon carcinoma(HT29),human cervical carcinoma(HeLa)and human liver carcinoma(HepG2)cell lines)in cancer cells through in vitro experiments.The structural characteristics and purity of CTs extract were determined using 13C NMR.The results showed that CTs exhibited higher in vitro antioxidant activities(2257.12±80.55 mg TEAC/g extract,605.3±1.82 mg TEAC/g extract and 1014.03±1.20 mg TEAC/g extract in FRAP,ABTS and DPPH assay,respectively)and demonstrated anti-microbial activities toward selected Gram’s positive and Gram’s negative bacteria tested with MIC and MBC value at 6.25–50 mg/mL.Furthermore,among other selected cancer cells,CTs also demonstrated cytotoxic activity toward human breast cancer cells(MCF-7)(IC50=38.33±2.08mg/mL).Characteristic of apoptosis such as cell shrinkage,nuclear condensation and apoptotic bodies were shown in MCF-7.These preliminary investigations have provided scientific rationale to use CTs as an alternative therapy for various oxidative and inflammatory associated diseases.©2016 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Mazni Abu Zarin Ho Yin Wan Azizul Isha Nurdin Armania | 2016 | Food Science and Human Wellness2016，5，2： | 9 |
| 2 | Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study显示文摘AIM Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4(TLR4) in hepatitis B virus(HBV) infection.METHODS Real time PCR was used to analyze the transcription of TLR4 signaling molecules, cell cycle regulators and HBV DNA viral load after triggering the Hep G2.2.15 cells with TLR4 specific ligand. Nuclear factor(NF)-κB translocation on TLR4 activation was analyzed using microscopic techniques. Protein and cell cycle analysis was done using Western Blot and FACS respectively.RESULTS The present study shows that TLR4 activation represses HBV infection. As a result of HBV suppression, there are several changes in host factors which include partial release in G1/S cell cycle arrest and changes in host epigenetic marks. Finally, it was observed that anti-viral action of TLR4 takes place through the NF-κB pathway.CONCLUSION The study shows that TLR4 activation in HBV infection brings about changes in hepatocyte microenvironment and can be used for developing a promising therapeutic target in future. | Dipanwita Das Neelakshi Sarkar Isha Sengupta Ananya Pal Debraj Saha Manikankana Bandopadhyay Chandrima Das Jimmy Narayan Shivram Prasad Singh Runu Chakravarty | 2016 | World Journal of Gastroenterology2016，22，47： | 4 |
| 3 | Transanal colorectal resection using natural orifice translumenal endoscopic surgery ( NOTES )显示文摘 | Isha Ann Emhoff Grace Clara Lee Patricia Sylla | 2014 | Digestive Endoscopy2014，，： | 3 |
| 4 | FEM based Electromagnetic Signature Analysis of Winding Inter-turn Short-Circuit Fault in Inverter fed Induction Motor显示文摘The intent of this paper is to analyze the electromagnetic signature of stator winding inter-turn short-circuit fault in a closed loop speed controlled Induction Motor(IM)employing Finite Element Method.Stator winding short-circuit nearly covers 21%of faults in IM.Diagnosing the inter-turn fault at an incipient stage is one of the challenging task in the area of fault detection of IM to prevent crucial damages in industrial applications.Also detecting the faults in inverter fed IM under variable speed applications under varying load is one of the major issues in industrial drives.As the signatures of electromagnetic field contains the entire data in association with the location of rotor,stator and mechanical parts of the motor,a regular monitoring of fields in the airgap can be used to diagnose the inter-turn fault in the stator winding of IM.In this direction,an IM is modeled with several inter-turn fault severities like 30 turns,15 turns,5 turns&1 turn short using ANSYS Maxwell FEA tool and coupled with ANSYS Simplorer for loading arrangements.The PWM inverter with closed loop speed controlled strategy is implemented in Matlab Simulink and co-simulated with ANSYS Simplorer to integrate all the components in one common simulation platform environment for accurate design&analysis for realistic simulation.Several electromagnetic variables like flux density,flux lines and airgap flux density distribution over the machine are analyzed.The spatial FFT spectrum of radial component of flux density in the airgap contains the information related to the diagnosis of inter-turn fault at the incipient stage. | Praveen Kumar N Isha T B | 2019 | CES Transactions on Electrical Machines and Systems2019，3，3： | 2 |
| 5 | Deep Learning Based Automated Detection of Diseases from Apple Leaf Images显示文摘In Agriculture Sciences, detection of diseases is one of the mostchallenging tasks. The mis-interpretations of plant diseases often lead towrong pesticide selection, resulting in damage of crops. Hence, the automaticrecognition of the diseases at earlier stages is important as well as economicalfor better quality and quantity of fruits. Computer aided detection (CAD)has proven as a supportive tool for disease detection and classification, thusallowing the identification of diseases and reducing the rate of degradationof fruit quality. In this research work, a model based on convolutional neuralnetwork with 19 convolutional layers has been proposed for effective andaccurate classification of Marsonina Coronaria and Apple Scab diseases fromapple leaves. For this, a database of 50,000 images has been acquired bycollecting images of leaves from apple farms of Himachal Pradesh (H.P)and Uttarakhand (India). An augmentation technique has been performedon the dataset to increase the number of images for increasing the accuracy.The performance analysis of the proposed model has been compared with thenew two Convolutional Neural Network (CNN) models having 8 and 9 layersrespectively. The proposed model has also been compared with the standardmachine learning classifiers like support vector machine, k-Nearest Neighbour, Random Forest and Logistic Regression models. From experimentalresults, it has been observed that the proposed model has outperformed theother CNN based models and machine learning models with an accuracy of99.2%. | Swati Singh Isha Gupta Sheifali Gupta Deepika Koundal Sultan Aljahdali Shubham Mahajan Amit Kant Pandit | 2022 | Computers, Materials & Continua2022，，4： | 2 |
| 6 | A model for virtual network embedding across multiple infrastructure providers using genetic algorithm显示文摘Network virtualization is an important aspect in cloud computing, where network is assumed to be consisting of infinite amount of nodes and links. The substrate network(physical network), has limited capacity and so virtual network embedding on the substrate network becomes a problem. Virtual network embedding is a computationally hard problem, considering various constraints on nodes and links. The proposed work applies Genetic Algorithm for the virtual network embedding problem for mapping multiple virtual network requests on infrastructure providers managing multiple substrate networks. Performance evaluation, through simulations,indicates that the proposed model preforms better for the performance metrics such as infrastructure provider revenue, acceptance ratio and node and link utilization in comparison to few other contemporary mapping models. | Isha PATHAK Deo Prakash VIDYARTHI | 2017 | Science China(Information Sciences)2017，60，4： | 2 |
| 7 | Biomimetic mineralized hybrid scaffolds with antimicrobial peptides显示文摘Infection in hard tissue regeneration is a clinically-relevant challenge.Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field.Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties.The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides.The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity.The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells.The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers. | Zhou Ye Xiao Zhu Isha Mutreja Sunil Kumar Bod Nicholas G.Fischer Anqi Zhang Christine Lui Yipin Qi Conrado Aparicio | 2021 | Bioactive Materials2021，6，8： | 2 |
| 8 | Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after car- diac surgery 显示文摘 | Isha J Dent C Tarabishi R | 2005 | Lancet2005，365，4： | 1 |
| 9 | Role of decision aids in orthopaedic surgery显示文摘Medical treatment of patients inherently entails the risk of undesired complication or side effects. It is essential to inform the patient about the expected outcomes, but also the possible undesired outcomes. The patients preference and values regarding the potential outcomes should be involved in the decision making process. Even though many orthopaedic surgeons are positive towards shared decision-making, it is minimally introduced in the orthopaedic daily practice and decision-making is still mostly physician based. Decision aids are designed to support the physician and patient in the shareddecision-making process. By using decision aids, patients can learn more about their condition and treatment options in advance to the decision-making. This will reduce decisional conflict and improve participation and satisfaction. | Isha A ten Have Michel PJ van den Bekerom Derek FP van Deurzen Michel GJS Hageman | 2015 | World Journal of Orthopedics2015，6，11： | 1 |
| 10 | Role of quinoids in estrogen carcinogenesis 显示文摘 | Bolton J L P isha E Zhang F | 1998 | Chem Res Toxicol1998，11，10： | 1 |
| 11 | R eduction o fpostoperative ile u s by early enteral n u tritio n in patientsundergoing m ajor re cta l surgery: prospective, random ized,co n tro lle d tria l 显示文摘 | Petra G Fanny F Luyer M isha D | 2014 | Ann Surg2014，259，4： | 1 |
| 12 | Risk factors and strategies for prevention of depression, anxiety and eating disorders among adolescents during the coronavirus disease 2019 (COVID-19) pandemic: a review显示文摘The purpose of this review is to identify prevalent trends and risk factors in depression,anxiety,and eating disorders in the adolescent population in the post coronavirus disease 2019(COvID-19)scenario.We examined the literature published on adolescent mental health since the COVID-19 pandemic.We chose to summarize studies published from 2019 to 2022,using bibliographic search tools.We developed criteria for selecting articles for our review using diagnostic indicators and keywords.Mental health conditions such as depression,anxiety and eating disorders are commonly prevalent in this population and have shown increasing rates in the past three years.Some risk factors associated with these diagnoses include reduction in social interaction,increased workloads,routine shifts,sleep quality,social media usage and parental involvement.Routines,sleep cycles,physical activity,and social media should all be considered as a part of prevention in this population.Approaches that seem to be successful include maintaining social ties and avoiding negative social media usage with harmful content.Increased global public awareness,as well as parental awareness,through media campaigns,is critical to slowing the spread of mental health challenges in adolescents and teenagers in the post-COvID-19 era. | Rea Pillai Isha Patel Rajesh Balkrishnan | 2023 | Global Health Journal2023，7，2： | 1 |
| 13 | Microscale anaerobic digestion of point source components of organic fraction of municipal solid waste显示文摘 | Chanakya H N Isha Shanma Ramachandra T V | 2009 | Waste Management2009，29，4： | 1 |
| 14 | Nonparametric estimation of a two dimensional continuous–discrete density function by wavelets显示文摘 | Christophe Chesneau Isha Dewan Hassan Doosti | 2014 | Statistical Methodology2014，，： | 1 |
| 15 | Exploring the bioactive potential of Serriatia marcescens VITAPI (Acc: 1933637) isolated from soil显示文摘背景 Serratia 是有效地生产解朊的酶的细菌的最重要的组之一并且知道拥有反煽动性的性质。当前的学习的主要焦点是从 Serratia mascescens 提取酶 serratiopeptidase 和颜料 prodigiosin。Prodigiosin 是细菌 Serratia marcescens 生产的红有颜色的颜料。因为它的大应用,它作为一个珍贵分子正在出现。Serratia marcescens 的 pigmented 紧张不比颜料得非的紧张剧毒,这已经被证明了。而且我们获得了的紧张从显示那 prodigiosin 的农场土壤,生产能用这紧张安全地被带。在礼品的方法学习, isolate VITASP 紧张被词法、生物化学、分子的研究证实。酶和颜料为抗氧化剂被分析,反煽动性、细胞毒素的性质。结果 isolate 进一步与 99% 类似作为 Serratia 被证实并且鉴别 marcescens。有 86% 的显示出的有势力基清除效果和酶被发现禁止 83% 的提取颜料,它与维生素酸标准相比重要。在里面处于控制试验性的条件的颜料的反煽动性的效果揭示了的 vitro 它在 88% 点的保护和有 90% 的酶。阿司匹林被用作参考药。现在的调查结果展出了集中依赖者抑制。颜料的细胞毒素的生物鉴定显示出是的 IC 50 值(50 ) 有与积极控制相比统计上重要的 63% cytotoxicity 的 g/mL。结论因此,它看起来是补救的必需品和申请研究。它可以结果对在解决与人的健康联系的许多问题的人类高度有益。 | Aruna Muthukumar Pallavi Pradeep Isha Thigale Mohanasrinivasan V. Jemimah Naine S. C. Subathra Devi | 2016 | Frontiers in Biology2016，11，6： | 1 |
| 16 | Microscale anaerobic digestion of point source components of organic fraction of municipal solid waste显示文摘 | Chanakya H N Isha Sharma Ramachandra T V | | 0，，04： | 1 |
| 17 | Multiresolution Wavelet Analysis for Improved Reservoir Description显示文摘 | Isha S Roland NH Stanford U | | 0，，02： | 1 |
| 18 | Crystal Structure and Interaction of Phycocyanin with β-Secretase: A Putative Therapy for Alzheimerμs Disease显示文摘 | Niraj Kumar Singh Syed S. Hasan Jitendra Kumar Isha Raj Amrin A. Pathan Asha Parmar Shazi Shakil Samudrala Gourinath Datta Madamwar | 2014 | CNS & Neurological Disorders - Drug Targets2014，，： | 1 |
| 19 | Micro- scale anaerobic digestion of point source components of organic fraction of municipal solid waste显示文摘 | Chanakya H N Isha Sharma Ramachandra T V | 2009 | Waste Man- agement2009，29，4： | 1 |
| 20 | Safe Drinking Water for Low-Income Regions 显示文摘 | Susan A Zachary B Isha R | 2015 | Annu Rev Environ Resour2015，40，： | 1 |
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