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1篇 您的检索式：作者名="Jimmy Narayan"

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		题名	作者	年代	出处	被引量
	1	Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study显示文摘AIM Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4(TLR4) in hepatitis B virus(HBV) infection.METHODS Real time PCR was used to analyze the transcription of TLR4 signaling molecules, cell cycle regulators and HBV DNA viral load after triggering the Hep G2.2.15 cells with TLR4 specific ligand. Nuclear factor(NF)-κB translocation on TLR4 activation was analyzed using microscopic techniques. Protein and cell cycle analysis was done using Western Blot and FACS respectively.RESULTS The present study shows that TLR4 activation represses HBV infection. As a result of HBV suppression, there are several changes in host factors which include partial release in G1/S cell cycle arrest and changes in host epigenetic marks. Finally, it was observed that anti-viral action of TLR4 takes place through the NF-κB pathway.CONCLUSION The study shows that TLR4 activation in HBV infection brings about changes in hepatocyte microenvironment and can be used for developing a promising therapeutic target in future.	Dipanwita Das Neelakshi Sarkar Isha Sengupta Ananya Pal Debraj Saha Manikankana Bandopadhyay Chandrima Das Jimmy Narayan Shivram Prasad Singh Runu Chakravarty	2016	World Journal of Gastroenterology2016，22，47：	4

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