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您的检索式：作者名="Nicholas G.Fischer"
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| 1 | Biomimetic mineralized hybrid scaffolds with antimicrobial peptides显示文摘Infection in hard tissue regeneration is a clinically-relevant challenge.Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field.Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties.The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides.The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity.The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells.The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers. | Zhou Ye Xiao Zhu Isha Mutreja Sunil Kumar Bod Nicholas G.Fischer Anqi Zhang Christine Lui Yipin Qi Conrado Aparicio | 2021 | Bioactive Materials2021，6，8： | 2 |
| 2 | Junctional epithelium and hemidesmosomes:Tape and rivets for solving the“percutaneous device dilemma”in dental and other permanent implants显示文摘The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth’s imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth’s enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant - as a model percutaneous device - placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists. | Nicholas G.Fischer Conrado Aparicio | 2022 | Bioactive Materials2022，7，12： | 0 |
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