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53篇 您的检索式：作者名="Samudrala"

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	题名	作者	年代	出处	被引量
1	Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss.	Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya	2012	International Journal of Oral Science2012，4，2：	5
2	Cadaveric morphometric analysis foratlanta1 lateral mass screw placement显示文摘	Wang MY Samudrala S	2004	Neurosurgery2004，54，6：	1
3	Scoring functions for ab initio protein structure prediction显示文摘	Enoch S Huang Ram Samudrala Britt H Park	2000	Methods Mol Biol2000，143，1：	1
4	Complications during anterior surgery of the lumbar spine: an anatomically based study and review显示文摘	Samudrala S Khoo LT Rhim SC	1999	Neurosurg Focus1999，7，6：	1
5	Analysis of reliability indices from Humphrey visual field tests in an urban glaucoma population显示文摘	Birt CM Shin DH Samudrala V	1997	Ophthalmology1997，104，：	1
6	Surgical treatment of gunshot injuries to the mandible显示文摘	Newlands SD Samudrala S Katzenmeyer WK	2003	Otolaryngol Head Neck Surg2003，129，3：	1
7	Subsonic and intersonic mode II crack propagation with a rate-dependent cohesive zone显示文摘	Samudrala O Huang Y Rosakis A J	2002	Journal of the Mechanics and Physics of Solids2002，50，6：	1
8	Identification of potential HIV-1 targets of minocycline 显示文摘	JENWITHEESUK E SAMUDRALA R	2007	Bioinformatics2007，23，20：	1
9	Caries induced cytokine network in the odontoblast layer of human teeth 显示文摘	Horst OV Horst J A Samudrala R	2011	BMC Immunol2011，12，：	1
10	A combined approach for ab initio construction of low resolution protein tertiary structures from sequence显示文摘	Samudrala R Xia Y Levitt M	1999	Pac Symp Biocomput1999，，：	1
11	Scoring functions for ab initio protein structure prediction显示文摘	Huang E S Samudrala R Park B H	2000	Methods tool biol2000，1，143：	1
12	Cracks faster than the shear wave speed显示文摘	ROSAKIS A J SAMUDRALA O COKER D	1999	Science1999，284，：	1
13	Functional annotation from predicted protein interaction networks显示文摘	McDermott J Bumgarner R Samudrala R	2005	Bioinformatics2005，21，：	1
14	An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction显示文摘	Samudrala R Mult J	1998	Mol Biol1998，275，：	1
15	A Graph-theoretic Algorithm for Comparative Modeling of Protein Structure显示文摘	Samudrala P Moult J	1998	Journal Molecular Biology1998，279，2：	1
16	Crystal Structure and Interaction of Phycocyanin with β-Secretase: A Putative Therapy for Alzheimerμs Disease显示文摘	Niraj Kumar Singh Syed S. Hasan Jitendra Kumar Isha Raj Amrin A. Pathan Asha Parmar Shazi Shakil Samudrala Gourinath Datta Madamwar	2014	CNS & Neurological Disorders - Drug Targets2014，，：	1
17	Identifiying inhibitors of the SARS coronavirus proteinase显示文摘	Jenwitheesuk E Samudrala R	2003	Bioorg Med Chem Lett2003，13，22：	1
18	Disguising itself--insights into Plasmodium falciparttm binding and immune evasion from the DBL crystal structure显示文摘	Howell DP Samudrala R Smith JD	2006	Mol Biochem Parasitol2006，148，1：	1
19	Functional annotation from predicted protein inter-action networks 显示文摘	McDermott J Bumgarner R Samudrala R	2005	Bioinformatics2005，21，：	1
20	Accelerated protein structure comparison using TM-score-GPU 显示文摘	HUNG L H SAMUDRALA R	2012	Bioinformatics2012，25，16：	1

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