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| 1 | Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis显示文摘AIM:To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute pancreatitis.METHODS:Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in rats.The mast cell inhibitor cromolyn was administered intraperitoneally(i.p.) 30 min before pancreatitis induction.The pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation were evaluated.Peritoneal and alveolar macrophages were obtained and the expression of tumor necrosis factor α was determined.Myeloperoxidase activity was measured to evaluate the effect of mast cell inhibition on the progression of the inflammatory process.Finally,the effect of plasma on cultured mast cells or macrophages was evaluated in vitro.RESULTS:The mast cell stabilizer signif icantly reduced inflammation in the pancreas and lung and the activation of alveolar macrophages but had no effect on peritoneal macrophages.Mast cell degranulation was observed in the pancreas during pancreatitis but no changes were observed in the lung.Plasma from rats with pancreatitis could activate alveolar macrophages but did not induce degranulation of mast cells in vitro.CONCLUSION:Pancreatic mast cells play an important role in triggering the local and systemic inflammatory response in the early stages of acute pancreatitis.In contrast,lung mast cells are not directly involved in the inflammatory response related to pancreatic damage. | Inmaculada Lopez-Font Sabrina Gea-Sorlí Enrique de-Madaria Luis M Gutiérrez Miguel Pérez-Mateo Daniel Closa | 2010 | World Journal of Gastroenterology2010，16，27： | 10 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Effect of the prefermentative addition of copigments on the polyphenolic composition of Tempranillo wines after malolactic fermentation 显示文摘 | Inmaculada A Aleixandre J L Garcia M J Lizama V Aleixandre-Tud6 J L | 2009 | European Food Research and Technology2009，228，： | 1 |
| 4 | Intracerebral VEGF injection highly upregulates AQP4 mRNA and protein in the perivascular space and glia limitans externa 显示文摘 | Inmaculada R Alberto M Josefina C | 2008 | Neurochemistry International2008，52，45： | 1 |
| 5 | Apheis: Health Impact Assessment of Long-term Exposure to PM 2.5 in 23 European Cities显示文摘 | Elena Boldo Sylvia Medina Alain Tertre Fintan Hurley Hans-Guido Mücke Ferrán Ballester Inmaculada Aguilera | 2006 | European Journal of Epidemiology2006，，6： | 1 |
| 6 | Chemical characteristics and mineral composition of quinoa by near‐infrared spectroscopy显示文摘 | M Inmaculada González Martín Guillermo Wells Moncada Susana Fischer Olga Escuredo | 2014 | Food Agric2014，，5： | 1 |
| 7 | The application of a weight of evidence approach to compare the quality of coastal sediments affected by acute(Prestige2002)and chronic(Bay of Algeciras)oil spills显示文摘 | Carmen M C Inmaculada R Garmen S | 2008 | Environmental Pollution2008，156，2： | 1 |
| 8 | Purification and biological characterization of haloein H1 from Haloferax mediterranei M2a显示文摘 | Gonzalo P Inmaculada M Ricardo A | 2002 | Int Mierobiol2002，67，5： | 1 |
| 9 | A pilot study of β-interferon for treatment of patients with chronic hepatitis B who failed to respond to α-interferon显示文摘 | Raquel M Gregorio G Inmaculada F | 2002 | J Hepatology2002，37，： | 1 |
| 10 | Functional char- acterization of chitin and chitosan显示文摘 | Inmaculada A Marian M Ruth H | 2009 | Current Chemical Biology2009，3，： | 1 |
| 11 | Pea pod, broad bean pod and okara, potential sources of functional compounds显示文摘 | INMACULADA M A ARACELI R C MARIA-JOSE V S | 2010 | Food Science & Technology2010，43，9： | 1 |
| 12 | The hnpact of Urbanization on CO2 Emissions: Evidence from Developing Countries 显示文摘 | Inmaculada M Z Antonello M | 2011 | Ecological Economics2011，70，7： | 1 |
| 13 | Nonparametric model comparison and uncertainty evaluation for signal strength indoor location显示文摘 | Carlos K F Inmaculada M J Alicia G C | 2009 | IEEE Transactions on Mobile Computing2009，8，9： | 1 |
| 14 | Lang-term rosults with tetracyclinepleurodesis显示文摘 | Inmaculada A Luis M Carmen H | 1994 | Chest1994，2，106： | 1 |
| 15 | Changes in the diabetic retinopathy epidemiology after 14 years in a population of Type 1 and 2 diabetic patients after the new diabetes mellitus diagnosis criteria and a more strict control of the patients显示文摘 | Pedro Romero-Aroca Juan Fernández-Balart Marc Baget-Bernaldiz Inmaculada Martinez-Salcedo Isabel Méndez-Marín Mercè Salvat-Serra Jose Antonio Buil-Calvo | 2009 | Journal of Diabetes and Its Complications2009，，4： | 1 |
| 16 | Physical and mental component summaries score of the SF-36 in coronary patients显示文摘 | María Soto Inmaculada Failde Soledad Márquez | 2005 | Quality of Life Research2005，14，3： | 1 |
| 17 | Soybean seeds and its by-product okara as sources of dietary fibre. Measurement by AOAC and Englyst methods显示文摘 | Araceli Redondo-Cuenca M a José Villanueva-Suárez Inmaculada Mateos-Aparicio | 2007 | Food Chemistry2007，，3： | 1 |
| 18 | Gravity Model:An Application to Trade Between Regional Blocs显示文摘 | Inmaculada M | 2003 | Atlantic Economic Journal2003，31，： | 1 |
| 19 | Optimization of the Chromatographic Conditions for the Determination of Hormones by Gas Chromatography with Mass Spectrometry Detection 显示文摘 | Inmaculada G Luisa Sarabia M | 2005 | Anal Chim Acta2005，544，12： | 1 |
| 20 | Amplification and disruption of the phenylacetyl-CoA lig- ase gene of penicillium chrysogenum encoding an ary-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase显示文摘 | LAMASMACEIRAS M INMACULADA V RODIGUEZ E | 2006 | Biochem2006，395，： | 1 |
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