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| 1 | Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis:What does evidence suggest?显示文摘AIM:To determine whether or not the use of antioxidant supplementation aids in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.METHODS:A systematic review of randomized controlled trials(RCTs) was made to evaluate the preventive effect of prophylactic antioxidant supplementation in post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).The inclusion criteria included:acute post-endoscopic retrograde cholangiopancreatography pancreatitis in adults; randomized clinical trials with the use of any antioxidant as an intervention compared with placebo,to reduce PEP.The outcome measure was the incidence and severity of PEP.Twelve RCTs involving 3110 patients since 1999 wereincluded.The antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),N-acetylcysteine(NAC) in three trials,and allopurinol in six trials.The group of patients treated with NAC received different doses; either oral or intravenous,and allopurinol-treated patients received five different oral doses in two different administration periods.The results are expressed with raw numbers,proportions,as well as mean and standard deviations.The incidence of pancreatitis between groups was analyzed with Pearson's χ2 test or Fisher's exact test(F).The main outcome is expressed as relative risks and 95%CI.RESULTS:The incidence of pancreatitis in all antioxidant treatment groups was 8.6%,whereas it was 9.7% in the control group.The antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),NAC in three trials,and allopurinol in six trials.In allopurinol trials,three different dosifications were used; two trials reported a low dosage(of less than 400 mg),two trials reported a moderate dose(600 mg) and the remaining two employed higher doses(more than 900 mg).Supplementation was not associated with a significant reduction in the incidence of PEP [relative risk(RR) = 0.93; 95%CI:0.82-1.06; P = 0.28].In addition,the incidences of PEP in patients treated with allopurinol and those treated with other antioxidants were similar to that observed in patients who received the placebo(RR for trials with allopurinol,0.92; 95%CI:0.78-1.08; P = 0.31) and,with the use of other antioxidants,the incidence of PEP was 8.9%,whereas it was 9.7% in the control group(RR = 0.95; 95%CI:0.77-1.18; P = 0.19).CONCLUSION:Antioxidant supplementation shows no beneficial effect on the incidence of PEP.There is a lack of robust trials to support the use of antioxidants for prevention. | Clotilde Fuentes-Orozco Carlos Davalos-Cobian Jesus Garcia-Correa Gabriela Ambriz-Gonzalez Michel Dassaejv Macias-Amezcua Jesus Garcia-Renteria Jorge Rendon-Felix Mariana Chavez-Tostado Lizbeth Araceli Cuesta-Marquez Andrea Socorro Alvarez-Villasenor Ana Olivia Cortes-Flores Alejandro Gonzalez-Ojeda | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity显示文摘The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no cure.Prematurity,low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin deficiency in the human neonate leading to cerebral palsy and cognitive impairment.In the developing brain,oligodendrocyte(OL)maturation occurs perinatally,and immature OLs are particularly vulnerable.Cell replacement therapy is often considered a viable option to replace progenitors that die due to glutamate excitotoxicity.We previously reported directed specification and mobilization of endogenous committed and uncommitted neural progenitors by the combination of transferrin and insulin growth factor 1(TSC1).Here,considering cell replacement and integration as therapeutic goals,we examined if OL progenitors(OLPs)grafted into the brain parenchyma of mice that were subjected to an excitotoxic insult could rescue white matter injury.For that purpose,we used a well-established model of glutamate excitotoxic injury.Four-day-old mice received a single intraparenchymal injection of the glutamate receptor agonist N-methyl-D-aspartate alone or in conjunction with TSC1 in the presence or absence of OLPs grafted into the brain parenchyma.Energetics and expression of stress proteins and OL developmental specific markers were examined.A comparison of the proteomic profile per treatment was also ascertained.We found that OLPs did not survive in the excitotoxic environment when grafted alone.In contrast,when combined with TSC1,survival and integration of grafted OLPs was observed.Further,energy metabolism in OLPs was significantly increased by N-methyl-D-aspartate and modulated by TSC1.The proteomic profile after the various treatments showed elevated ubiquitination and stress/heat shock protein 90 in response to N-methyl-D-aspartate.These changes were reversed in the presence of TSC1 and ubiquitination was decreased.The results obtained in this pre-clinical study indicate that the use of a combinatorial intervention including both trophic support and healthy OLPs constitutes a promising approach for long-term survival and successful graft integration.We established optimal conditioning of the host brain environment to promote long-term survival and integration of grafted OLPs into an inflamed neonate host brain.Experimental procedures were performed under the United States Public Health Service Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care Committee at(UCLA)(ARC#1992-034-61)on July 1,2010. | Megumi Hirose-Ikeda Brian Chu Paul Zhao Omar Akil Elida Escalante Laurent Vergnes Carlos Cepeda Araceli Espinosa-Jeffrey | 2020 | Neural Regeneration Research2020，15，3： | 4 |
| 3 | Secondary male hypogonadism: a prevalent but overlooked comorbidity of obesity显示文摘与肥胖联系的男性腺机能减退是一个很流行的条件并且与肥胖的流行流行同时正在增加。低睾丸激素层次与减少的瘦质量支持更高胖的质量。男性腺机能减退与联系 cardiometabolic 复杂并发症的增加有关,例如高血压,类型 2 糖尿病 mellitus,新陈代谢的症候群,和心血管的疾病。它肥胖的 comorbidity 在在风险正在变得并且应该被评估并且对待病人更明显的影响。涉及这种关系的机制包括身体作文变化, adipokines 的存在,胰岛素抵抗,和另外的因素,其中一些仍然是未知的。重量损失和治疗与肥胖和性腺机能减退改进在病人的生活的新陈代谢的侧面和质量代替睾丸激素层次;这些有益的效果取决于治疗形式和治疗的持续时间。当增加心血管的风险没被显示,睾丸激素代替治疗的使用可以被显示,并且回顾的研究与新陈代谢的症候群在人在事件建议减小并且打 2 糖尿病。 | Maria Molina-Vega Araceli Munoz-Garach Miguel Damas-Fuentes Jose Carlos Fernfindez-Garcia Francisco J inahones | 2018 | Asian Journal of Andrology2018，20，6： | 2 |
| 4 | Evidence against the participation of a pharmacokinetic interaction in the protective effect of single-dose curcumin against gastrointestinal damage induced by indomethacin in rats显示文摘OBJECTIVE:To determine the role of a pharmacokinetic interaction in the protective effect of curcumin against the gastric damage induced by indomethacin administration as such or as its prodrug acemetacin.METHODS:Wistar rats orally received single dose of indomethacin(30 mg/kg) with and without curcumin(30 mg/kg);gastric injury was evaluated by determining the total damaged area.Additional groups of rats received an oral single dose of indomethacin(30 mg/kg) or its prodrug acemetacin(34.86 mg/kg) in the presence or absence of curcumin(30 mg/kg).Indomethacin and acemetacin concentrations in plasma from blood draws were determined by high-performance liquid chromatography.Plasma concentration-against-time curves were constructed,and bioavailability parameters,maximal concentration(C_(max)) and area under the curve to the last sampling time(AUC_(0-t)) were estimated.RESULTS:Concomitant administration of indomethacin and curcumin resulted in a significantly reduced gastric damage compared to indomethacin alone.However,co-administration of curcumin did not produce any significant alteration in the bioavailability parameters of indomethacin and acemetacin after administration of either the active compound or the prodrug.CONCLUSION:Curcumin exhibits a protective effect against indomethacin-induced gastric damage,but does not produce a reduction of the bioavailability of this nonsteroidal anti-inflammatory drug,indomethacin.Data thus suggest that a pharmacokinetic mechanism of action is not involved in curcumin gastroprotection. | Liliana Zazueta-Beltran Lorena Medina-Aymerich Nadia Estela Diaz-Triste Aracely Evangelina Chavez-Pina GUberto Castaneda-Hernandez Leticia Cruz-Antonio | 2017 | Journal of Integrative Medicine2017，15，2： | 2 |
| 5 | Efficacy of Methotrexate in Ankylosing Spondylitis:A Randomized,Double Blind,Placebo Controlled Trial显示文摘 | LAURA GONZALEZ-LOPEZ ARACELI GRACIA-GONIALEZ MONICA VAZQUEZ-DEL-MERCADO | 2004 | Journal of Rheumatology2004，31，： | 1 |
| 6 | Current role in facial allograft transplantation:what have we learned?显示文摘Face transplant(FT)has evolved enormously in the last 10 years since the successful completion of the first facial transplant.This procedure has become a new reconstructive option for complex facial deformities to restore the anatomy of patients with severely disfigured faces.The authors review the literature and discuss the main surgical,immunological,and ethical aspects as well as the results described in patients undergoing FT.To date there have been more than thirty FT worldwide.The main indication was post-traumatic deformity.In all cases a standard immunosuppression was performed with three drugs,although acute rejection episodes were observed,that could be controlled with conventional immunosuppressive regimen.Overall,functional and aesthetic results have been excellent at short-term and high satisfaction rate exceeded initial expectations,although long-term data are still scarce.Major complications were opportunistic infections.Five deaths that occurred have reopened the ethical debate about the potential complications and concerns of providing informed consent to recipients.Continuous progresses in microsurgical techniques and preoperative planning have promoted the evolution from partial to full FT.All these are on the basis of accurate and careful selection of well-motivated candidates.The next challenge will be getting new immunosuppressive treatment strategies.Although clinical experience has demonstrated the FT viability,it is still considered an experimental procedure in which we have much to learn to define its true role in the current reconstructive surgery and resolve major technical,medical and ethical problems involved. | Pedro Infante-Cossio Fernando Barrera-Pulido Tomas Gomez-Cia Domingo Sicilia-Castro Alberto Garcia-Perla-Garcia Purificacion Gacto-Sanchez Jose Maria Hernandez-Guisado Araceli Lagares-Borrego Rocio Narros-Gimenez Juan-David Gonzalez-Padilla | 2016 | Plastic and Aesthetic Research2016，3，1： | 1 |
| 7 | Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury显示文摘 | Daadi MM Davis AS Arac A | 2010 | Stroke2010，41，3： | 1 |
| 8 | A multicentre randomized trial of combined individual and telephone counselling for smoking cessation显示文摘 | Josep M. Ramon Isabel Nerin Araceli Comino Cristina Pinet Francesc Abella José M a Carreras Marta Banque Antoni Baena Sergio Morchon Adriana Jimenez-Muro Adriana Marqueta Assumpcio Vilarasau Raquel Bullon Cristina Masuet-Aumatell | 2013 | Preventive Medicine2013，，： | 1 |
| 9 | Chemical studies of anthoeyanins: A review 显示文摘 | ARACELI C O MA DE LOURDES P H MA ELENA P H | 2009 | Food Chemistry2009，113，4： | 1 |
| 10 | Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside显示文摘 | Araceli Sala M.Carmen Recio Guillermo R Schinella Salvador Má?ez Rosa M Giner Miguel Cerdá-Nicolás José-Luis R??os | 2003 | European Journal of Pharmacology2003，，1： | 1 |
| 11 | Effects of sevoflurane, isoflurane and propofol infusions on post-operative recovery criteria in geriatric patients显示文摘 | Arac C Kaya G Karamanlioglu B | 2005 | J Int Med Res2005，33，： | 1 |
| 12 | Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury显示文摘 | Daadi MM Davis AS Arac A | 2010 | Stroke2010，41，3： | 1 |
| 13 | Assessment of outcome following decompressive craniectomy for malignant middle cerebral artery infarction in patients older than 60 years of age显示文摘 | Arac A Blanchard V Lee M | 2009 | Neurosurg Focus2009，26，6： | 1 |
| 14 | Minireview mechanisms involved in the cellular calcium homeostasis in vascular smooth muscle: calcium pumps 显示文摘 | Jesus M Araceli E Ana B | 1999 | LifeSci1999，64，05： | 1 |
| 15 | Lung at Thin-Section CT: Influence of Muhiple-segment Reconstruction on Image Quality显示文摘 | Arac M Oner AY Celik H | 2003 | Radiology2003，229，5： | 1 |
| 16 | Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats显示文摘 | Araceli Diaz -Ruiz Camilo Riosc lvonne Duartea | 1999 | Neuroscience Letters1999，266，1： | 1 |
| 17 | Ethanol production from steam-explosion pretreated wheat straw显示文摘 | Ignacio Ballesteros Ma José Negro José Miguel Oliva Araceli Caba?as Paloma Manzanares Mercedes Ballesteros | 2006 | Applied Biochemistry and Biotechnology (-)2006，，1： | 1 |
| 18 | Characterization of Outer Membrane Vesicles from Brucella melitensis and Protection Induced in Mice显示文摘 | Eric Daniel Avila-Calderón Ahidé Lopez-Merino Neeta Jain Humberto Peralta Edgar Oliver López-Villegas Nammalwar Sriranganathan Stephen M. Boyle Sharon Witonsky Araceli Contreras-Rodríguez Georgios Pappas | 2011 | Clinical and Developmental Immunology2011，，： | 1 |
| 19 | Chemical studies of anthocyanins, a review显示文摘 | ARACELI CASTANEDA-OVANDO MDLP | 2009 | Food Chemistry2009，，113： | 1 |
| 20 | Gold nanoparticle-based electrochemical biosensors显示文摘 | José M. Pingarrón Paloma Yá?ez-Sede?o Araceli González-Cortés | 2008 | Electrochimica Acta2008，，19： | 1 |
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